Similar studies for GEO DataSets (Select 3599) - GEO DataSets

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Items: 20

Select item 35991.

Eset depletion effect on embryonic stem cell

Analysis of embryonic stem (ES) cells following shRNA knock-down of Eset. Eset is a histone H3 lysine 9 (H3K9) methyltransferase critical for development of the inner cell mass (ICM) from which ES cells are derived. Results provide insight into the role of Eset in ES cell differentiation.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL6333
Series:: GSE17439
6 Samples

Download data

DataSet

Accession:: GDS3599

ID:: 3599

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000176422.

Genome-wide mapping of Eset-binding sites and H3K9me3 state in mouse embryonic stem cells

(Submitter supplied) The histone H3 lysine 9 (H3K9) methyltransferase Eset is an epigenetic regulator critical for the development of the inner cell mass (ICM). Although ICM-derived embryonic stem (ES) cells are normally unable to contribute to the trophectoderm (TE) in blastocysts, we find that depletion of Eset by shRNAs leads to differentiation with the formation of trophoblast-like cells and induction of trophoblast-associated gene expression. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL9185
3 Samples

Download data: BED, TXT

Series

Accession:: GSE17642

ID:: 200017642

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000174393.

Global gene-expression analyses of the Eset knock-down ES cells

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3599
Platform:: GPL6333
6 Samples

Download data: TXT

Series

Accession:: GSE17439

ID:: 200017439

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000129994.

Gata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development

(Submitter supplied) The first lineage decisions during mouse development lead to establishment of embryonic and extraembryonic tissues. The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4 and promoting trophoblast fate at the blastocyst stage. Here we show that the transcription factor Gata3 is coexpressed with Cdx2 in the blastocyst and that overexpression of Gata3 in embryonic stem cells is sufficient to induce expression of trophoblast genes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS3948 GDS3949
Platform:: GPL1261
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE12999

ID:: 200012999

Select item 2000129865.

Expression of Cdx2 or Gata3 in R1 mouse embryonic stem cells

(Submitter supplied) To identify whether Cdx2 or Gata3 can activate trophoblast specific gene expression when expressed in R1 ES cells. To assess the dependency of Gata3 activity on Cdx2, Gata3 was also expressed in Cdx2-null ES cells. Keywords: gene expression

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
10 Samples

Download data: CEL, CHP

Series

Accession:: GSE12986

ID:: 200012986

Select item 2000129856.

Differentiation time course of trophoblast stem cells

(Submitter supplied) To characterized the changes in gene expression during the differentiation of TS cells. TS cells can be derived from two time point during embryogenesis, cell lines tested were from each of these time points. Keywords: time course

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
14 Samples

Download data: CEL, CHP

Series

Accession:: GSE12985

ID:: 200012985

Select item 39497.

Cdx2 and Gata3 overexpression effect on R1 embryonic stem cell line

Analysis of R1 embryonic stem (ES) cells overexpressing transcription factor Cdx2 or Gata3 and cultured under trophoblast stem (TS) cell derivation conditions. Gata3-expressing Cdx2-null ES cells also examined. Results provide insight into the roles of Gata3 and Cdx2 in trophoblast development.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation, 3 protocol sets

Platform:: GPL1261
Series:: GSE12999
10 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3949

ID:: 3949

Select item 39488.

Trophoblast stem cell differentiation in vitro

Analysis of trophoblast stem (TS) cell lines TS3.5 and TS6.5 derived from 2 time points during embryogenesis (from blastocyst and E6.5 embryos, respectively) and differentiated over 6 days. Results provide insight into the molecular basis of trophoblast development.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell line, 2 protocol, 7 time sets

Platform:: GPL1261
Series:: GSE12999
14 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3948

ID:: 3948

Select item 2000568779.

Arid3a is essential to execution of the first cell fate decision via direct embryonic and extraembryonic transcriptional regulation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL8321 GPL17021
19 Samples

Download data: CEL, TXT

Series

Accession:: GSE56877

ID:: 200056877

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005687610.

Arid3a modulates the first cell fate decision by direct regulation of both embryonic and extraembryonic gene expression (ChIP-Seq)

(Submitter supplied) Arid3a, a transcription factor known for its requirement in B-lymphocyte development, has been recently identified as a member of ES cell pluripotency network. Arid3a is moderately expressed in ES cells, and its expression is gradually increased during differentiation. Since Arid3a shows the highest expression in placenta, we hypothesized that Arid3a may play important roles in TE development. We report that Arid3a is a central regulator of both TE-specific and pluripotency-associated gene expression during ES cell differentiation. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
7 Samples

Download data: TXT

Series

Accession:: GSE56876

ID:: 200056876

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005685311.

Arid3a modulates the first cell fate decision by direct regulation of both embryonic and extraembryonic gene expression (microarray)

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
12 Samples

Download data: CEL

Series

Accession:: GSE56853

ID:: 200056853

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002859312.

KMT1E Mediated H3K9 Methylation Is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation

(Submitter supplied) Dynamic regulation of histone methylation by methyltransferases and demethylases plays a central role in regulating the fate of embryonic stem (ES) cells. The histone H3K9 methyltransferase KMT1E, formerly known as ESET or Setdb1, is essential to embryonic development as the ablation of the Setdb1 gene results in peri-implantation lethality and prevents the propagation of ES cells. However, Setdb1- null blastocysts do not display global changes in H3K9 methylation or DNA methylation, arguing against a genome- wide defect. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL

Series

Accession:: GSE28593

ID:: 200028593

Select item 20006756213.

The single-stranded DNA binding protein Ssbp3 promotes trophoblast differentiation of mouse embryonic stem cells

(Submitter supplied) Unlimited self-renewal and developmental pluripotency are hallmarks of embryonic stem cells. Both properties are precisely controlled by the extrinsic signals and intrinsic factors and have been extensively investigated. However, factors capable of converting ES cells to extra-embryonic lineages have been poorly studied. Here we found that overexpression of Ssbp3 dramatically up-regulated trophoblast specific markers. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE67562

ID:: 200067562

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001837114.

SetDB1 Contributes to Repression of Genes Encoding Developmental Regulators and Maintenance of ES Cell State

(Submitter supplied) Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintain ES cells are less well understood. A high-throughput shRNA screen was used to identify novel chromatin regulators that influence ES cell state. Loss of histone H3K9 methyltransferases, particularly SetDB1, had the most profound effects on ES cells. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
11 Samples

Download data: TXT

Series

Accession:: GSE18371

ID:: 200018371

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006215015.

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL11002 GPL15103
17 Samples

Download data

Series

Accession:: GSE62150

ID:: 200062150

PubMed Full text in PMC Similar studies

Select item 20006214916.

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast [RNA-Seq]

(Submitter supplied) Reprogramming of ES cells towards the trophoblast lineage, and specifally into self-renewing TS cells, can seemingly be achieved by manipulation of transcription factors such as Cdx2 and Oct4, or modulation of signalling cascades, notably Ras signalling. Here we analyze the arising cells from such treatment in detail for the efficiency and completeness of the reprogramming process. We find that the reprogrammed cells retain an epigenetic and transcriptional memory of their ES cell origin and are not equal to bona fide trophectoderm-derived TS cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15103
8 Samples

Download data: TXT

Series

Accession:: GSE62149

ID:: 200062149

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006213817.

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast [MeDIP-Seq]

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL11002 GPL15103
9 Samples

Download data: TXT

Series

Accession:: GSE62138

ID:: 200062138

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20021625618.

Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos

(Submitter supplied) During the first lineage segregation, a mammalian totipotent embryo differentiates into inner cell mass (ICM) and trophectoderm (TE). However, how transcription factors (TFs) regulate this earliest cell fate decision in vivo remains elusive, with their regulomes primarily inferred from cultured cells. Here, we investigated the TF regulomes during the first mouse lineage specification across 6 stages, spanning the pre-initiation, initiation, commitment, and maintenance phases. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL24247 GPL21273 GPL18480
93 Samples

Download data: BW, TXT

Series

Accession:: GSE216256

ID:: 200216256

PubMed Similar studies

Select item 20010000019.

Fosl1 transdifferentiate embryonic stem cells to differentiated trophoblast stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: BED

Series

Accession:: GSE100000

ID:: 200100000

PubMed Full text in PMC Similar studies

Select item 20009998420.

Fosl1 transdifferentiate embryonic stem cells to differentiated trophoblast stem cells (RNA-seq)

(Submitter supplied) During mammalian embryonic development, the first lineage commitment event gives rise to two distinct cell populations: the trophectoderm (TE) and the inner cell mass (ICM). The TE consists of outer cells of the blastocyst and ultimately forms the placenta while the ICM gives rise to all the embryonic tissues. Numerous transcription factors (TFs) guiding ICM differentiation into different embryonic tissues have been characterized. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
3 Samples

Download data: TXT

Series

Accession:: GSE99984

ID:: 200099984

PubMed Full text in PMC Similar studies SRA Run Selector

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