GEO DataSets

Analysis of hearts from animals on a low-salt diet for two weeks. Reduced sodium intake inversely correlates with cardiac mortality in hypertensive patients. Results provide insight into the molecular basis of the detrimental effect of low-salt diets on the heart.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL3738

Series:

GSE17149

7 Samples

Download data: CEL, CHP

(Submitter supplied) We hypothesized that a LS intake leads to a cascade of events involving increases in plasma AII, the AT1 receptor, NADPH oxidase and O2˙ production and ultimately to reduced NO bioactivity. This reduced NO bioactivity results in altered control of the coronary circulation and cardiac metabolism. This study was undertaken to determine the global changes in cardiac gene expression in dogs fed LS diet (0.5% NaCl) for two weeks. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Dataset:

GDS3594

Platform:

GPL3738

7 Samples

Download data: CEL, CHP

(Submitter supplied) Hyperhomocysteinemia (HHCy) has been established as a risk factor for development of cardiovascular disease. Previous studies have focused on the alterations in vascular biology such as vasodilation and white cell infiltration. We have shown that in rats and mice with HHCy, superoxide reduces the ability of NO to regulate mitochondrial function. Molecular mechanisms responsible for HHCy changes in cardiac function and myocardial metabolism are not yet understood. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Dataset:

GDS2517

Platform:

GPL3979

8 Samples

Download data: CEL

Analysis of hearts of animals given drinking water containing 10 g/L of L-methionine to induce chronic hyperhomocysteinemia (HHcy). HHcy is characterized by an elevation in plasma homocysteine, and is a risk factor for atherosclerosis. Results provide insight into the impact of HHcy on the heart.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL3979

Series:

GSE5260

8 Samples

Download data: CEL

(Submitter supplied) The global changes in cardiac gene expression in dogs with alloxan-induced diabetes were studied using Affymetrix Canine Array. Cardiac RNA was extracted from the control and DM (n=4). The array data revealed that 797 genes were differentially expressed (P<0.01; fold change of at least ±2). 150 genes were expressed at significantly greater levels in diabetic dogs and 647 were significantly reduced.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

8 Samples

Download data: CEL, CHP