GEO DataSets

Analysis of skeletal muscles from young and aged individuals undergoing vigorous endurance exercise training for over 4 years. Results provide insight into the effects of endurance exercise on age-related insulin resistance and mitochondrial dysfunction.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 protocol sets

Platform:

GPL570

Series:

GSE9103

37 Samples

Download data: CEL

(Submitter supplied) Aging is associated with mitochondrial dysfunction and insulin resistance. We conducted a study to determine the role of long-term vigorous endurance exercise on age-related changes in insulin sensitivity and various indices of mitochondrial functions. Keywords: The effect of excises in young and old human subjects by transcription profiling

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3182

Platform:

GPL570

40 Samples

Download data: CEL

(Submitter supplied) Myosine heavy chain I was overexpressed in mouse skeletal muscle. The transgenic mice, as well as the wild type mice, were endurance trained on treadmill for 5 days/week over 8 weeks at 80% peak aerobic capacity in comparison with untrained mice. The gene expression profiles of the skeletal muscles from wild-type trained (WTT) and untrained (WTUT), and transgenic trained (TGT) and untrained (TGUT) were measured using Affymetrix Mouse430A 2.0 GeneChips. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

20 Samples

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(Submitter supplied) Age-related declines in cardiorespiratory fitness and physical function are mitigated by regular endurance exercise in older adults. This may be due, in part, to changes in the transcriptional program of skeletal muscle following repeated bouts of exercise. However, the impact of chronic exercise training on the transcriptional response to an acute bout of endurance exercise has not been clearly determined. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

57 Samples

Download data: TXT

(Submitter supplied) Evaluation of the influence of primary and secondary aging on the manifestation of molecular and cellular hallmarks of aging is a challenging and currently unresolved issue. Our study represents the first demonstration of the distinct role of primary aging and both chronic inflammation and physical inactivity – the most important drivers of secondary aging, in the regulation of transcriptomic and proteomic profiles in human skeletal muscle. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21697

59 Samples

Download data: TXT

(Submitter supplied) Gene expression profiles generated from skeletal muscle biopsies taken from participants of the HERITAGE family study. Participants completed an endurance training regime in which a skeletal muscle biopsy was taken prior to the start and after the final session of the program. Biopsies were used to generate Affymetrix gene expression microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

82 Samples

Download data: CEL