GEO DataSets

Analysis of LM2 breast cancer cells depleted for metadherin (MTDH), a cell surface protein in breast tumors that mediates lung metastasis. LM2 cells were grown alone or on a monolayer of lung microvascular endothelial cells. Results provide insight into molecular mechanisms underlying MTDH action.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 growth protocol, 2 protocol sets

Platform:

GPL4133

Series:

GSE9187

12 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of human breast cancer cell line LM2, a subline of MDA-MB-231 highly metastatic to lung when injected to nude mice, to identify the genes that are regulated after the metastasis gene metadherin is knocked down. Keywords: Genetic modification

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3179

Platform:

GPL4133

12 Samples

Download data: TXT

(Submitter supplied) To examine whether MTDH is a novel RNA binding protein and regulates either metabolism or translation of various mRNAs, we performed a RNA-binding protein immunoprecipitation (RIP) with MTDH and IgG antibodies, and the resulting immunoprecipitated RNA was subjected to a microarray to identify transcripts associating with MTDH. In addition we tested the effect of PI3K inhibition using BEZ235 (a dual PI3K/mTOR inhibitor) on the association of MTDH with target mRNAs.

Organism:

Homo sapiens

Type:

Other

Platform:

GPL5175

9 Samples

Download data: CEL

(Submitter supplied) During TCGA data analysis, we found that expression of many genes was correlated with the expression of MTDH in estrogen receptor (ESR) positive cancers. The effect of estradiol and MTDH on gene expression in endometrial cancer cells was further analyzed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

12 Samples

Download data: IDAT

(Submitter supplied) To identify HGF/Met regulated genes, we performed expression microarray analysis after inducible activation of Met receptor in primary cultures of hepatocytes established from wild-type control (Alb-Cre +/-) and Met conditional knockout mice (Alb-Cre +/-; Met Fl/Fl). Keywords: time series design

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3148

Platform:

GPL1536

60 Samples

Download data

Analysis of Met-deficient hepatocytes treated with HGF for up to 24 hours. HGF/Met signaling controls invasive growth and metastasis in a variety of cancers, including hepatocellular carcinoma. Results identify a Met-dependent gene expression signature that may help elucidate the oncogenic process.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation, 5 time sets

Platform:

GPL1536

Series:

GSE4451

60 Samples

Download data

(Submitter supplied) Integrated DNA and expression array analysis in primary human breast tumors identified chromosome 8q22 copy number gain and a suite of over-expressed genes in this region highly relevant to subsequent recurrence. 8q copy gain is associated with increased risk of distant metastasis despite adjuvant chemotherapy and multiple genes from 8q22 are overexpressed and have pleiotropic effects, contributing to tumor growth, survival, and reduced killing of tumor cell by chemotherapy.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

115 Samples

Download data: CEL

(Submitter supplied) Genome-wide study of LOH and copy number changes associated with breast cancer, their subtypes and their clinical outcome including response to chemotherapy in women sufferred from breast cancinomas. Mapping chromosome 8q22 copy gain associated with poor clinical outcome of breast cancer and discovery of 8q22 genes relevant to specific drug resistance.

Organism:

Homo sapiens

Type:

SNP genotyping by SNP array; Genome variation profiling by SNP array

Platform:

GPL1266

88 Samples

Download data: CEL, TXT

(Submitter supplied) Evidence suggests that BRCA1 mutation associated tumors have increased sensitivity to DNA damaging agents like cisplatin. Sporadic triple negative breast cancers (TNBC) have many phenotypic similarities to BRCA1 tumors and may have a similar sensitivity to cisplatin. We tested the efficacy of cisplatin monotherapy in 28 TNBC patients in a single arm neoadjuvant trial with outcome measured by pathologic treatment response quantified using the Miller-Payne scale. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

84 Samples

Download data: CEL

(Submitter supplied) PURPOSE: Validated biomarkers predictive of response/resistance to anthracyclines in breast cancer are currently lacking. The neoadjuvant TOP trial, in which patients with estrogen receptor (ER)-negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to evaluate the predictive value of topoisomerase IIα (TOP2A) and to develop a gene expression signature to identify those patients who do not benefit from anthracyclines. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

120 Samples

Download data: CEL, TXT

(Submitter supplied) We used microarrays to identified the chracteristics of CR cells that differ from primary tumor.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL21185

4 Samples

Download data: TXT

(Submitter supplied) Worldwide, breast cancer (BRCA) is the most common malignant tumor in women. Adriamycin (ADR) is considered one of the most effective agents for the treatment of BRCA, but its efficacy as a curative agent is compromised by intrinsic resistance and the acquisition of multidrug resistance characteristics during chemotherapy. The underlying mechanisms resulting in ADR resistance in BRCA remain poorly understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL22755

6 Samples

Download data: TXT

(Submitter supplied) An oligo array based high-resolution analysis of copy number alterations in 171 primary breast tumors of relatively small size and low NPI, and 49 breast cancer cell-lines. Objectives of the study were to study the molecular taxonomy and the genomic aberration patterns in a breast cancer cohort representative of breast cancer demographics. Keywords: array comparative genomic hybridisation

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL5737

220 Samples

Download data: TXT