Hepatocyte growth factor effect on Met receptor-knockout primary hepatocytes: time course
Summary:
Analysis of Met-deficient hepatocytes treated with HGF for up to 24 hours. HGF/Met signaling controls invasive growth and metastasis in a variety of cancers, including hepatocellular carcinoma. Results identify a Met-dependent gene expression signature that may help elucidate the oncogenic process.
Kaposi-Novak P, Lee JS, Gòmez-Quiroz L, Coulouarn C et al. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 2006 Jun;116(6):1582-95. PMID: 16710476
