GEO DataSets

Analysis of Met-deficient hepatocytes treated with HGF for up to 24 hours. HGF/Met signaling controls invasive growth and metastasis in a variety of cancers, including hepatocellular carcinoma. Results identify a Met-dependent gene expression signature that may help elucidate the oncogenic process.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation, 5 time sets

Platform:

GPL1536

Series:

GSE4451

60 Samples

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(Submitter supplied) To identify HGF/Met regulated genes, we performed expression microarray analysis after inducible activation of Met receptor in primary cultures of hepatocytes established from wild-type control (Alb-Cre +/-) and Met conditional knockout mice (Alb-Cre +/-; Met Fl/Fl). Keywords: time series design

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3148

Platform:

GPL1536

60 Samples

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(Submitter supplied) We analyzed the molecular changes in a mouse c-MET over-expression model of hepatocellular carcinoma (HCC).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6794

49 Samples

Download data: CEL

(Submitter supplied) Hepatocellular carcinoma (HCC) affects millions of people worldwide and is a lethal malignancy for which there are no effective therapies. To identify prognostic gene markers for liver cancer, we conducted transcriptome profiling of frozen tissues (tumor and non-tumor) from 300 early-to-advanced stage HCCs plus 40 cirrhotic and 6 normal livers.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10687

557 Samples

Download data: CEL

(Submitter supplied) We used Affymetrix microarray profiling to analyze gene expression patterns in healthy donor liver as well as tumor and paired non-tumor tissue of HCC patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL3921 GPL571

488 Samples

Download data: CEL, TXT

(Submitter supplied) We used array-based comparative genomic hybridization (arrayCGH) of 76 hepatocellular carcinomas (HCCs) to search for genetically disrupted genes.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL4093

76 Samples

Download data: TXT

(Submitter supplied) To identify therapeutic targets with high specificity to HCC, we searched for genes significantly up-regulated in HCC over corresponding non-tumor liver using high-density microarrays Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

20 Samples

Download data: CEL

(Submitter supplied) The variability in the prognosis of hepatocellular carcinoma (HCC) patients suggests that HCC may comprise several distinctive biological phenotypes. These phenotypes may result from different neoplastic pathways during the tumorigenesis and/or from a different cell of origin. Here we address if the transcriptional characteristics of the HCC would provide insight into the cellular origin of the tumors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1528

98 Samples

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(Submitter supplied) Global gene expression patterns of 91 human hepatocellular carcinomas (HCC) were analyzed to define the molecular characteristics of the tumors and to test the prognostic value of the expression profiles. Total RNAs were isolated from frozen liver tissue using CsCl density gradient centrifugation methods. Total RNA from 18 normal livers were pooled and used as reference in entire microarray experiments. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1528

182 Samples

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(Submitter supplied) Genetically modified mice have been extensively used for analyzing the molecular events that occur during the tumor development. However, in many cases, if not all, it is uncertain to what extent the mouse models reproduce features observed in the corresponding human conditions. This is due largely to lack of precise methods for direct and comprehensive comparison at the molecular level of the mouse and human tumors. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1529

133 Samples

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(Submitter supplied) Printing by the NCI-Frederick/LMT Microarray Research Facility Surface type: non-adsorptive, polylysine-coated glass Attachment: covalent, (UV-treated polylysine) Array description: The custom arrays are manufactured by the NCI Frederick Laboratory of Molecular Technology Microarray Facility (NIH/NCI/SAIC/LMT). Microarrays are printed with BioRobotics TAS II robotic arrayer from Genomic Solutions (http://www.genomicsolutions.com) that is fitted with a printhead containing 32 SMP3 printing pins from Telechem International (http://www.arrayit.com). more...

Organism:

Mus musculus

7 Series

242 Samples

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(Submitter supplied) Attachment: UV cross-linked Array description: The custom arrays are manufactured by the NCI Advanced Technology Center Microarray Facility (NIH/NCI/CCR/ATC). Microarrays are printed with GeneMachines robotic arrayer from Genomic Solutions (http://www.genomicsolutions.com) that is fitted with a printhead containing 32 SMP3 printing pins from Telechem International (http://www.arrayit.com). Protocol: The human long oligonuleotide probe set contains 21,329 optimized 70mers (plus controls) obtained from Operon (http://www.operon.com/ ) . more...

Organism:

Homo sapiens

2 DataSets

16 Series

1045 Samples

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(Submitter supplied) The kras transgenic line was generated by using a mifepristone-inducible transgenic system in combination with a Cre-loxP system. Most of the induced transgenic fish developed hepatocellular carcinoma at 6 month-post-induction.

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16034

4 Samples

Download data: TXT

(Submitter supplied) To compare the characteristics and mechanisms of Myc and xmrk induced zebrafish liver tumor, next generation sequencing-based SAGE analyses were used to examine the transcriptomes of tumor and control samples. The results indicated that relatively small overlaps of significantly deregulated genes and biological pathways among different zebrafish liver tumor models.Nevertheless, they all significantly correlate with advanced or very advanced human hepatocellular carcinoma (HCC). more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10658

6 Samples

Download data: TXT

(Submitter supplied) Three pairs of hepatocellular carcinoma and adjacent non-tumor tissues were from 3 male patients suffering from stage I or II HCC with hepatitis C virus background. RNA-Seq libraries were prepared from total RNA using polyA enrichment strategy. The libraries were sequenced on Illumina HiSeq2000 instruments.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

6 Samples

Download data: TXT

(Submitter supplied) Comparison of hepatocellular carcinoma with non-cancerous liver tissue. Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS274

Platform:

GPL257

87 Samples

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Generation of a molecular signature for metastatic hepatocellular carcinoma (HCC) and identification of genes relevant to metastasis and patient survival. Osteopontin identified as molecular marker for defining metastatic potential.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 disease state, 40 individual, 3 tissue sets

Platform:

GPL257

Series:

GSE364

87 Samples

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(Submitter supplied) Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma (HCC) at the age of 12 months and older (Schmidt et al., 2008). Hepatic transcript expression profiles were obtained for IQGAP2 knockout and wild-type control mice of two age groups, 6- and 24-month-old. Liver samples from 24-month-old IQGAP2 knockout mice were HCC tumors, livers from all other groups were tumor-free. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4874

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of liver from IQ-motif containing GTPase-activating protein 2 (IQGAP2) KOs at 6- and 24-months of age. IQGAP2 is a member of a multidomain scaffolding protein family that also includes IQGAP1 and IQGAP3. Results provide insight into a potential tumor suppressive role for IQGAP2 in liver.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE46646

12 Samples

Download data: CEL

(Submitter supplied) We performed gene expression profiling of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and mixed type of combined HCC and CC (CHC). In comparison of the profiles, a novel class of HCC expressing CC-like traits was identified.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

90 Samples

Download data: CEL