GEO DataSets

Analysis of fibroblast-like synoviocytes (FLS) treated with TGFalpha alone or in combination with SB203580, an inhibitor of p38. FLS, targets of proinflammatory cytokines, are involved in rheumatoid arthritis (RA). Results provide insight into the role of the p38 pathway in RA pathogenesis.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 agent, 2 protocol sets

Platform:

GPL2877

Series:

GSE7826

14 Samples

Download data: TXT

(Submitter supplied) Gene expression affected by TNFa was investigated, then, p38 inhibitor SB203580 was used to investigate p38 signal pathway. Keywords: p38 signal response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2885

Platform:

GPL2877

14 Samples

Download data: TXT

(Submitter supplied) Aged humans and rodents are susceptible to infection with Streptococcus pneumoniae bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines and increased production of interleukin (IL)-10 by macrophages (Mphi) from aged mice. To understand the molecular basis of cytokine dysregulation in aged mouse Mphi, a microarray analysis was performed on RNA from resting and lipopolysaccharide (LPS)-stimulated Mphi from aged and control mice using the Affymetrix Mouse Genome 430 2.0 gene chip. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL

(Submitter supplied) Clopidogrel is associated with a series of gastrointestinal side effects, such as bleeding complications and recurrent gastric ulcer; however, their mechanisms are largely unclear. In this study, human gene expression microarray and gene ontology analysis were utilized to evaluate the effects of clopidogrel on gene expression in human gastric epithelial cells (GES-1) Keywords: Clopidogrel; Gastric injury; GES-1 cell line

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

6 Samples

Download data: TXT

(Submitter supplied) Cells have the ability to respond and adapt to environmental changes through the activation of stress-activated protein kinases (SAPKs). Although it has been shown that p38 SAPK signalling participates in the regulation of gene transcription, there is not a comprehensive genome-wide transcription study reported to date describing neither the role of the p38 SAPK on the immediate response to stress and its kinetics nor a comparative vision of the genes that respond to different stimuli that activate the p38 SAPK. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7042

30 Samples

Download data: TXT

(Submitter supplied) As part of the civil aviation safety program to define the adverse effects of ethanol on flying performance, we present results of our DNA microarray analysis of samples from a timecourse study of individuals given ethanol orally, and then evaluated by breathalyzer to monitor blood alcohol content (BAC). At five blood alcohol levels, T1-T5, blood was drawn such that the samples represented 0%, 0.04%, 0.08% BAC, and return to 0.04%, and 0.02% BAC. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4938 GDS6177

Platform:

GPL570

54 Samples

Download data: CEL

Analysis of blood from subjects administered orange juice w/o alcohol. Blood collected at time points corresponding to collection times for the alcohol group in GDS4938. These results, together with those from GDS4938, provide insight into molecular response of blood during acute ethanol exposure.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 individual, 2 protocol, 5 time sets

Platform:

GPL570

Series:

GSE20489

25 Samples

Download data: CEL

Analysis of blood from subjects administered orange juice with ethanol. Blood collected at Blood Alcohol Concentrations of 0%, 0.04%, 0.08%, declining 0.04% and 0.02%. These results, together with those from GDS6177, provide insight into molecular response of blood during acute ethanol exposure.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 6 individual, 2 protocol, 5 time sets

Platform:

GPL570

Series:

GSE20489

29 Samples

Download data: CEL