Fibroblast-like synoviocytes response to p38 MAPK inhibition and TGFalpha in vitro
Summary:
Analysis of fibroblast-like synoviocytes (FLS) treated with TGFalpha alone or in combination with SB203580, an inhibitor of p38. FLS, targets of proinflammatory cytokines, are involved in rheumatoid arthritis (RA). Results provide insight into the role of the p38 pathway in RA pathogenesis.
GPL2877:
Agilent-013162 Whole Rat Genome Microarray G4131A (Feature Number version)
Citation:
Zer C, Sachs G, Shin JM. Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-alpha signaling. Physiol Genomics 2007 Oct 22;31(2):343-51. PMID: 17652167
