GEO DataSets

Analysis of breast cancer MCF-7 cells following the induction of expression of nuclear LIM-only protein 4 (LMO4). LMO4 is upregulated in breast cancer. Results provide insight into the role of LMO4 in promoting tumor formation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL97

Series:

GSE7382

6 Samples

Download data: CEL

(Submitter supplied) The nuclear LIM-only protein LMO4 is upregulated in breast cancer, especially estrogen receptor negative tumors, and its overexpression in mice leads to hyperplasia and tumor formation. Here, we show that deletion of LMO4 in the mammary glands of mice leads to impaired lobuloalveolar development due to decreased epithelial cell proliferation. With the goal of discovering potential LMO4-target genes, we also developed a conditional expression system in MCF-7 cells for both LMO4 and a dominant negative (DN) form of its co-regulator, Co-factor of LIM domains (Clim/Ldb/Nli). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2787 GDS2788 GDS2789

Platforms:

GPL96 GPL97 GPL570

18 Samples

Download data: CEL

Analysis of breast cancer MCF-7 cells after the induction of expression of a dominant negative form of the cofactor of LIM domains (CLIM), a co-regulator of the nuclear LIM only protein 4 (LMO4). LMO4 is upregulated in breast cancer. Results provide insight into the role of LMO4 in tumor formation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE7382

6 Samples

Download data: CEL

Analysis of breast cancer MCF-7 cells following the induction of expression of nuclear LIM-only protein 4 (LMO4). LMO4 is upregulated in breast cancer. Results provide insight into the role of LMO4 in promoting tumor formation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL96

Series:

GSE7382

6 Samples

Download data: CEL

(Submitter supplied) Histone deacetylase 1 (HDAC1) is an enzyme that promotes deacetylation of acetylated lysine residues in histones and other proteins. Histone acetylation is often associated with gene activation and expression. Los of HDAC1 leads to severe problems in development and proliferation. Moreover, it seems to be the major histone deacetylase in mouse embryonic stem cells. We used microarrays to identify putative HDAC1 target genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2294

Platform:

GPL81

6 Samples

Download data: CAB, CEL, EXP, XLS

Analysis of embryonic stem cells lacking histone deacetylase 1 (HDAC1). HDACs catalyze the removal of acetyl groups from core histones resulting in chromatin compaction. Results provide insight into the role of HDAC1 in transcriptional regulation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE5583

6 Samples

Download data: CEL, EXP

(Submitter supplied) Comparison of control wild-type and Rb-/- prostate epithelial cell lines under untreated and serum-free conditions Keywords = prostate Keywords = epithelial Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS575

Platform:

GPL81

9 Samples

Download data

Comparison of retinoblastoma-deficient (Rb-/-) and control wild type prostate epithelial cell lines maintained in RPMI-1640 medium supplemented with 5% fetal bovine serum, or without serum for 48 hours.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell line, 2 growth protocol sets

Platform:

GPL81

Series:

GSE934

9 Samples

Download data

(Submitter supplied) Histone deacetylase 7 (HDAC7) is highly expressed in CD4+/CD8+ thymocytes and functions as a signal-dependent repressor of gene transcription during T cell development. In this study, we express HDAC7 mutant proteins in a T cell line and use DNA microarrays to identify transcriptional targets of HDAC7 in T cells. Gene expression changes are compared to differential gene expression profiles associated with positive and negative thymic selection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL5064

74 Samples

Download data: GPR

(Submitter supplied) The molecular hallmark of the Ewing family of tumors is the presence of balanced chromosomal translocations leading to the formation of chimerical transcription factors (i.e. EWS/FLI1) that play a pivotal role in the pathogenesis of Ewing tumors by deregulating gene expression. We have recently demonstrated that DAX1 (NR0B1), an orphan nuclear receptor which was not previously implicated in cancer, is induced by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors, suggesting that DAX1 is a biologically relevant target of EWS/FLI1-mediated oncogenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2895

12 Samples

Download data: TXT

(Submitter supplied) The aim was to carry out global analysis of gene expression changes occurring in the normal pubertal mouse mammary gland from the appearance to the regression of terminal end buds. Keywords: developmental time course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2721

Platform:

GPL339

14 Samples

Download data: CEL

Analysis of mammary glands of animals from pre-puberty to post-puberty. Results provide insight into the mechanisms underlying mammary gland development during puberty.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 5 age, 3 development stage sets

Platform:

GPL339

Series:

GSE6453

14 Samples

Download data: CEL

(Submitter supplied) LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies; however, in the absence of in vivo molecular characterization of their regulation, their identity as direct LMX1B targets remains hypothetical. We describe here the first molecular characterization of LMX1B target gene regulation. A tetracycline-inducible expression system and microarray analysis showed that a subset of NF-kappa B target genes, including IL-6 and IL-8 are upregulated in LMX1B-expressing HeLa cells. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6244 GPL4134

10 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grhl3, a conserved mammalian homologue of Grainyhead, which plays important roles in cuticle development in Drosophila. Get-1 interacts with the LIM-only protein LMO4, which is co-expressed in the developing mammalian epidermis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2629

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

Analysis of skins of embryos lacking Grainyhead-like epithelial transactivator (Get-1). Results provide insight into the role of Get-1 in epidermal differentiation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE7381

6 Samples

Download data: CEL, CHP

(Submitter supplied) Microarray analysis was used to compare the gene expression profiles of Deaf-1-transduced mouse mammary epithelial cells (MECs) relative to Deaf-1-deficient MECs.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3490

Platform:

GPL1261

4 Samples

Download data: CEL

Analysis of cultured mammary epithelial cells lacking or overexpressing the transcription factor Deaf-1. Deaf-1 is involved in mammary gland development and breast cancer. Results identify target genes of Deaf-1.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL1261

Series:

GSE12367

4 Samples

Download data: CEL

(Submitter supplied) Branching morphogenesis of the mammary gland is driven by the highly motile terminal end bud (TEB) throughout pubertal development. The stem cell enriched, proliferative TEB branches as it invades the mammary fat pad to create a complex network of ducts. The gene expression programs specific to the TEB and the differentiated duct are poorly understood. We conducted a time course analysis of gene expression in the TEB and duct throughout branching morphogenesis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

50 Samples

Download data: CEL, CHP

(Submitter supplied) Mice lacking the POU-domain transcription factor Brn3a exhibit marked defects in sensory axon growth and abnormal sensory apoptosis. We have determined the regulatory targets of Brn3a in the developing trigeminal ganglion using microarray analysis of Brn3a mutant mice. These results show that Brn3 mediates the coordinated expression of neurotransmitter systems, ion channels, structural components of axons and inter- and intracellular signaling systems. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1651 GDS1652

Platforms:

GPL82 GPL81

11 Samples

Download data

Analysis of embryonic day 13.5 trigeminal ganglia of Brn3a knockout mutants. Brn3a encodes a POU-domain transcription factor. Results provide insight into the molecular mechanisms underlying the essential role of the Brn3a protein in normal axon growth and neuronal survival.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 genotype/variation sets

Platform:

GPL82

Series:

GSE3895

5 Samples

Download data