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Links from GEO DataSets

Items: 12

1.
Full record GDS2663

Mre11 deficient sporulating cells

Analysis of Mre11 deficient cells at meiotic prophase during sporulation. Mre11 is important in homologous recombination, repair of DNA double strand breaks, activation of damage-induced checkpoint, and telomere maintenance. Results provide insight into the role of Mre11 in spore development.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array, count, 2 development stage, 4 genotype/variation sets
Platform:
GPL90
Series:
GSE6620
8 Samples
Download data: CEL
DataSet
Accession:
GDS2663
ID:
2663
2.

Expression data from wild type, mre11delta, rad50delta, and spo11Y135F at meiosis 0 hr and 4 hr.

(Submitter supplied) Mre11, together with Rad50 and Xrs2/NBS, plays pivotal roles in homologous recombination, repair of DNA double strand breaks (DSBs), activation of damage-induced checkpoint, and telomere maintenance. Using DNA microarray assays to analyze yeast mutants (mre11delta, rad50delta, and spo11Y135F) defective for meiotic DSB formation, we demonstrate that the absence of Mre11 in yeast causes specific effects on regulation of a class of meiotic genes for spore development. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Dataset:
GDS2663
Platform:
GPL90
8 Samples
Download data: CEL
Series
Accession:
GSE6620
ID:
200006620
3.

Physical interaction with Spo11 mediates the localisation of Mre11 to chromatin in meiosis and promotes its nuclease activity

(Submitter supplied) Meiotic recombination is of central importance for the proper segregation of homologous chromosomes and is initiated by DNA double-strand breaks (DSB) that depend on Spo11 and Mre11. Calibrated chromatin immunoprecipitation (ChIP) for Mre11 shows that Spo11 promotes Mre11 recruitment to chromatin, independent of DSB formation. A C-terminal deletion mutant deficient in Spo11 interaction severely reduces the association of Mre11 with meiotic chromatin. more...
Organism:
Saccharomyces cerevisiae; Nakaseomyces glabratus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL34086
12 Samples
Download data: TXT, XLSX
Series
Accession:
GSE253302
ID:
200253302
4.

Effects of temperatures on meiotic recombination in S. cerevisiae [CGH]

(Submitter supplied) Temperature is key for biological activities, but its role in meiotic recombination processes is less known. Here, we uncovered the patterns of meiotic recombination by monitoring the double strands DNA breaks in diploid strain ZK5 cells cultured at 14ºC, 30ºC, and 37ºC.
Organism:
Saccharomyces cerevisiae
Type:
Genome variation profiling by genome tiling array
Platform:
GPL23647
12 Samples
Download data: GPR
Series
Accession:
GSE100741
ID:
200100741
5.

Effectes of temperatures on meiotic recombination in S. cerevisiae

(Submitter supplied) Temperature is key for biological activities, but its role in meiotic recombination processes is less known. Here, we uncovered the patterns of meiotic recombination by monitoring the genotypes of diploid strain JSC22-1-derived spores formed at 14ºC, 30ºC, and 37ºC. These spores were analyzed by whole genome SNP microarray that can examine about 13,000 SNPs distinguishing W303-1A and YJM789 sequences throughout the genome.
Organism:
Saccharomyces cerevisiae
Type:
Genome variation profiling by genome tiling array; Genome variation profiling by SNP array
Platform:
GPL20144
84 Samples
Download data: GPR
Series
Accession:
GSE97667
ID:
200097667
6.

Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in yeast

(Submitter supplied) In eukaryotes, meiotic recombination events are distributed non-randomly in the genome with certain regions having high levels of recombination (hotspots) and others having low levels (coldspots). Species with similar DNA sequences (for example, chimpanzees and humans) can have strikingly different patterns of hotspots and coldspots. Below, using a microarray analysis that allows us to measure the frequency of the meiosis-specific double-strand DNA breaks (DSBs) of all 6000 yeast genes, we show that mutation of a single gene (SIR2), which encodes a histone deacetylase, significantly changes DSB frequencies of 12% of yeast genes, elevating DSBs of 5% and reducing DSBs of 7%. more...
Organism:
Saccharomyces cerevisiae
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL4414
24 Samples
Download data: GPR
Series
Accession:
GSE6245
ID:
200006245
7.

Affymetrix custom RNA microarray for WT and jhd2-delete strains in terminal spores (20h)

(Submitter supplied) RNA transcript signals were profiled in WT (MMY718) and jhd2∆ (MMY1879) terminally sporulated cultures (20h of sporulation) using Affymetrix high resolution tiling microarrays.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by genome tiling array
Platform:
GPL13990
4 Samples
Download data: CEL, TXT
Series
Accession:
GSE41002
ID:
200041002
8.

Nucleosome occupancy microarray for WT and jhd2-delete strains though sporulation

(Submitter supplied) WT (MMY718) and jhd2∆ (MMY1879) sporulating cell cultures were profiled for global nucleosome occupancy using Affymetrix high-resolution tiling arrays.
Organism:
Saccharomyces cerevisiae
Type:
Genome variation profiling by genome tiling array
Platform:
GPL13990
16 Samples
Download data: CEL, TXT
Series
Accession:
GSE40874
ID:
200040874
9.

omparison of gene expression during meiosis between wild-type and deficient strains of Coprinopsis cinerea

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Coprinopsis cinerea
Type:
Expression profiling by array
Platform:
GPL7697
44 Samples
Download data: GPR
Series
Accession:
GSE37968
ID:
200037968
10.

Comparison of gene expression during meiosis between wild-type and msh5-deficient strains of Coprinopsis cinerea

(Submitter supplied) Meiosis was compared in msh5-22 and wild type strains of C. cinerea at 6 time points spanning the meiotic timecourse. Abstract: The basidiomycete Coprinopsis cinerea is well-suited to studies of meiosis because meiosis progresses synchronously in ten million cells within each mushroom cap. Approximately 20% of C. cinerea genes exhibit changing expression during meiosis, but meiosis and mushroom development happen concurrently so differentially expressed genes might not be directly involved in meiotic processes. more...
Organism:
Coprinopsis cinerea
Type:
Expression profiling by array
Platform:
GPL7697
24 Samples
Download data: GPR
Series
Accession:
GSE37943
ID:
200037943
11.

Comparison of gene expression during meiosis between wild-type and rad50-deficient strains of Coprinopsis cinerea

(Submitter supplied) Meiosis was compared in rad50-1 and wild type strains of C. cinerea at 6 time points spanning the meiotic timecourse. Abstract: The basidiomycete Coprinopsis cinerea is well-suited to studies of meiosis because meiosis progresses synchronously in ten million cells within each mushroom cap. Approximately 20% of C. cinerea genes exhibit changing expression during meiosis, but meiosis and mushroom development happen concurrently so differentially expressed genes might not be directly involved in meiotic processes. more...
Organism:
Coprinopsis cinerea
Type:
Expression profiling by array
Platform:
GPL7697
20 Samples
Download data: GPR
Series
Accession:
GSE37942
ID:
200037942
12.

Dormancy-to-death transition in yeast spores occurs due to gradual loss of gene-expressing ability

(Submitter supplied) Dormancy is colloquially considered as extending lifespan by being still. Starved yeasts form dormant spores that wake-up (germinate) when nutrients reappear but cannot germinate (die) after some time. What sets their lifespans and how they age are open questions because what processes occur - and by how much - within each dormant spore remains unclear. With single-cell-level measurements, we discovered how dormant yeast spores age and die: spores have a quantifiable gene-expressing ability during dormancy that decreases over days to months until it vanishes, causing death. more...
Organism:
Saccharomyces cerevisiae W303
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29253
24 Samples
Download data: TXT
Series
Accession:
GSE159575
ID:
200159575
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