Similar studies for GEO DataSets (Select 2487) - GEO DataSets

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Items: 16

Select item 24871.

p38 mitogen-activated protein kinase overexpression effect on the heart

Analysis of left heart ventricles of transgenics overexpressing the mitogen-activated protein kinase (MAPK) p38 in their hearts. p38 is involved in the pathophysiology of inflammatory diseases. Results provide insight into the role of p38 in the heart.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL1355
Series:: GSE3866
10 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2487

ID:: 2487

Select item 2000038662.

p38 MAPK overexpression in heart in vivo.

(Submitter supplied) Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by using local adenovirus-mediated gene transfer of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38α in rats. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2487
Platform:: GPL1355
10 Samples

Download data: CEL, EXP

Series

Accession:: GSE3866

ID:: 200003866

Select item 2000098153.

Microarray Analysis of Differentially Expressed Genes in human bronchial cells(BEAS-2B) treated MTX

(Submitter supplied) Methotrexate (MTX) has been widely used for the treatment of a variety of tumors as well as for inflammatory diseases and rheumatoid arthritis (RA). MTX-induced toxicity has been a serious unpredictable side effect of the treatment and an important clinical problem. Possible causes include allergic, cytotoxic or immunologic reactions to this agent. We examined the consequences of the mechanism of MTX-induced pulmonary toxicity gene expression in BEAS-2B cells, huma bronchial cell line, by microarray. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1708
3 Samples

Download data: GPR

Series

Accession:: GSE9815

ID:: 200009815

Select item 2000009244.

Cardiopulmonary bypass (CPB) vs sham-operated controls

(Submitter supplied) heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords: other

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL153 GPL154
12 Samples

Download data

Series

Accession:: GSE924

ID:: 200000924

Select item 2000009225.

CPB vs sham-operated controls (1.2)

(Submitter supplied) hearts from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords = rat Keywords = heart Keywords = cytokine Keywords = inflammation Keywords: repeat sample

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL153
6 Samples

Download data

Series

Accession:: GSE922

ID:: 200000922

Select item 2000009216.

CPB vs sham-controls

(Submitter supplied) heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords = rat Keywords = cardiac Keywords = cytokine Keywords = inflammation Keywords: repeat sample

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL154
6 Samples

Download data

Series

Accession:: GSE921

ID:: 200000921

Select item 2000015687.

Ambrosino series 1

(Submitter supplied) Hybridizations were performed in triplicate, using total of 7 RNA samples extracted from 3 independent batches of proliferating cardiomyocyte cell line derived from p38alpha knockout mouse. In two hybridizations (Ambrosino 1, Ambrosino 2), the RNAs from p38alpha-/- and wt cells were labeled with Cy-5 and Cy-3-dUTP, respectively, whereas in the third hybridization (Ambrosino 3), the dyes were swapped. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1348
3 Samples

Download data

Series

Accession:: GSE1568

ID:: 200001568

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000035398.

Characterization of an Arabidopsis mutant deficient in the non-phosphorylating of GAPN gene.

(Submitter supplied) Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) is a conserved protein found in higher plants. In photosynthetic cells, the enzyme is involved in a shuttle transfer mechanism to export NADPH from the chloroplast to the cytosol. In this work, we demonstrate that GAPN gene express in leaves and roots at similar levels; showing the highest level of expression in flowers. To investigate the role of this enzyme in different plant tissues, we characterized a mutant from Arabidopsis thaliana having an insertion at the GAPN gene locus. more...

Organism:: Arabidopsis thaliana

Type:: Expression profiling by array

Platform:: GPL1941
3 Samples

Download data

Series

Accession:: GSE3539

ID:: 200003539

Select item 2000035309.

Distinct Gene Expression Profiles in Adult Mouse Heart Following Targeted MAP Kinase Activation

(Submitter supplied) Three major MAP kinase signaling cascades, ERK, p38 and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonal stimuli. In order to study the specific function of each MAP kinase branch in adult heart, we have generated three transgenic mouse models with cardiac specific and temporally regulated expression of activated mutants of Ras, MKK3 and MKK7, which are selective upstream activators for ERK, p38 and JNK, respectively. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1306
Platform:: GPL1261
36 Samples

Download data

Series

Accession:: GSE3530

ID:: 200003530

Select item 130610.

MAP kinase activation effect on heart: time course

Analysis of adult hearts after induction of activated transgene mutants of Ras, MKK3, or MKK7, which are specific upstream activators of the MAP kinases ERK, p38, and JNK respectively. Hearts examined at various time points up to 4 weeks following each transgene induction using tamoxifen.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 gender, 4 genotype/variation, 3 time sets

Platform:: GPL1261
Series:: GSE3530
36 Samples

Download data

DataSet

Accession:: GDS1306

ID:: 1306

Select item 20000410511.

Rat LAD IR study

(Submitter supplied) Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Keywords: rat heart ventricles, LAD - left anterior descending coronary artery, IR - ischemia-reperfusion

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS1959
Platform:: GPL341
12 Samples

Download data

Series

Accession:: GSE4105

ID:: 200004105

Select item 195912.

Ischemic myocardium response to reperfusion

Analysis of ischemic heart ventricles 2 or 7 days after reperfusion. Ischemia induced by occlusion of the left anterior descending coronary artery. Results provide insight into the molecular mechanisms involved in the early and late inflammatory phases of acute myocardial infarction.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 protocol, 2 time sets

Platform:: GPL341
Series:: GSE4105
12 Samples

Download data

DataSet

Accession:: GDS1959

ID:: 1959

Select item 20002253513.

Expression data from mouse liver on multisetp-exposure to ethylbenzene

(Submitter supplied) The processes involved in the adaptation of animals to environmental factors such as chemicals have not yet been fully elucidated. We focused on the adaptive potential of the mouse liver against hepatotoxic chemical-induced injury. We used microarrays to determine genes with adaptive transcriptional regulation against ethylbenzene, hepatotoxic chemical, on multistep-exposure.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE22535

ID:: 200022535

Select item 20002253414.

Expression data from PDK4 overexpressing (Ad-PDK4 infected) and control (Ad-control infected) mouse liver

(Submitter supplied) We identified PDK4 as a gene with adaptive transcriptional response to chemical stress. Although PDK4 is an energy resource regulator induced by starvation, expression of other fasting-inducible genes was unaffected, indicating additional physiological role of PDK4 for liver adaptation to the chemical stress. We used microarrays to determine genes with altered transcriptional level by PDK4 overexpression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
2 Samples

Download data: CEL

Series

Accession:: GSE22534

ID:: 200022534

Select item 20002006215.

In vivo identification of solar-responsive gene network

(Submitter supplied) Solar radiation is one of the biggest threats to the skin, eliciting a specific protective cellular response. To descipt the underlying mechanisms, we have chosen to study in vivo, epidermis gene expression of surface solar radiation (SSR)-irradiated skin using whole genome microarray (Agilent 44K).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1708
15 Samples

Download data: TXT

Series

Accession:: GSE20062

ID:: 200020062

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014394616.

Blood Serum Stimulates p38-Mediated Proliferation and Changes in Global Gene Expression of Adult Human Cardiac Stem Cells

(Submitter supplied) Global transcriptome analysis of blood serum-treated adult human cardiac stem cells shows p38-MAPK mediated changes of proliferation and survival compared with untreated cells