GEO DataSets

Analysis of whole adrenal glands collected at 4-hour intervals across a 24-hour period from adult females acclimated to a 12hr light, 12hr dark photoperiod. Results provide insight into the nature of oscillatory patterns of gene expression in the adrenal gland.

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array, count, 6 time sets

Platform:

GPL96

Series:

GSE2703

6 Samples

Download data: CEL

(Submitter supplied) Circadian regulation of gene expression in central and peripheral tissue has been studied in mice. The biomedical implications of this findings led us to the development of a model in which to study the circadian mechanisms underlying primate physiology. The objective of this experiment has been to identify genes that are circadianly regulated in the monkey (macaca mulatta) adrenal gland. We analyzed the data using three filters: the first one for presence in at least three out of six time points (presence call=P, P value<0.05). more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2110

Platform:

GPL96

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

30 Samples

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(Submitter supplied) This study was performed to characterize the rhythmic transcirptome of the murine adrenal gland with a focus on the corticosterone synthesis pathway. Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2232

Platform:

GPL1261

24 Samples

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Analysis of adrenal glands of wild type animals at various time points after transferring the animals from a light-day cycle to constant darkness. Results provide insight into the function of the adrenal cortical clock.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 12 time sets

Platform:

GPL1261

Series:

GSE4238

24 Samples

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(Submitter supplied) A cardinal symptom of Major Depressive Disorder (MDD) is the disruption of circadian patterns. Yet, to date, there is no direct evidence of circadian clock dysregulation in the brains of MDD patients. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human brain was difficult to characterize. Here we applied time-of-death analysis to gene expression data from high-quality postmortem brains, examining 24-hour cyclic patterns in six cortical and limbic regions of 55 subjects with no history of psychiatric or neurological illnesses ('Controls') and 34 MDD patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17027

670 Samples

Download data: CEL

(Submitter supplied) With aging, significant changes in circadian rhythms occur, including a shift in phase toward a “morning” chronotype and a loss of rhythmicity in circulating hormones. However, the effects of aging on molecular rhythms in the human brain have remained elusive. Here we employed a previously-described time-of-death analyses to identify transcripts throughout the genome that have a significant circadian rhythm in expression in the human prefrontal cortex (Brodmann’s areas (BA) 11 and 47). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

420 Samples

Download data: CEL, TXT