Similar studies for GEO DataSets (Select 200240293) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2002402931.

Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles [rna-seq]

(Submitter supplied) Microglia are resident immune cells of the brain that play important roles in mediating inflammatory responses in several neurological diseases via direct and indirect mechanisms. One indirect mechanism may involve extracellular vesicle (EV) release, so that the molecular cargo transported by microglia-derived EVs can have functional effects by facilitating intercellular communication. The molecular composition of microglia-derived EVs, and how microglial activation states impacts EV composition and EV-mediated effects in neuroinflammation, remain poorly understood. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
24 Samples

Download data: CSV

Series

Accession:: GSE240293

ID:: 200240293

PubMed Full text in PMC Similar studies

Select item 2002402952.

Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21273
60 Samples

Download data

Series

Accession:: GSE240295

ID:: 200240295

PubMed Full text in PMC Similar studies

Select item 2002402943.

Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles [mirna-seq]

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21273
24 Samples

Download data: CSV

Series

Accession:: GSE240294

ID:: 200240294

PubMed Full text in PMC Similar studies

Select item 2002402904.

Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles [bulk rna-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
12 Samples

Download data: CSV

Series

Accession:: GSE240290

ID:: 200240290

PubMed Full text in PMC Similar studies

Select item 2001140085.

Small RNA profiling of extracellular vesicles secreted by A549 cells infected with West Nile virus and treated with interferon alpha

(Submitter supplied) The goal of this study is to determine if infection with flavivirus (West Nile virus) and action of proinflamatory cytokine interferon alter incorporation of host RNAs into extracellular vesicles secreted by human cells.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: XLS

Series

Accession:: GSE114008

ID:: 200114008

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000803046.

RNA Sequencing Facilitates Quantitative Analysis of Primary Microglia Transcriptomes II

(Submitter supplied) Using RNA-seq, we report here that primary microglia (PM) cells have a distinct transcriptomic signature and express a unique cluster of transcripts in response to 2hrs or 4 hrs with LPS.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
9 Samples

Download data: TXT

Series

Accession:: GSE80304

ID:: 200080304

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000798987.

A novel synthetic jumonji H3K27 demethylase inhibitor GSK-J4 exert immunosuppressive activities

(Submitter supplied) Using RNA-seq, we report that jumonji H3K27 demethylase inhibitor, GSK-J4, exerts potent anti-inflammatory effects on LPS-stimulated BV-2 microglial cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
15 Samples

Download data: TXT

Series

Accession:: GSE79898

ID:: 200079898

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001024018.

Effect of monocyte- and osteoclast-derived extracellular vesicles on adipose tissue-derived mesenchymal stem/stromal cells

(Submitter supplied) Intercellular communication is essential in bone remodelling to ensure that new bone is formed with only temporary bone loss. Monocytes and osteoclasts actively take part in controlling bone remodelling by providing signals that promote osteogenic differentiation of mesenchymal stem/stromal cells (MSCs). Extracellular vesicles (EVs) have attracted attention as regulators of bone remodelling. EVs facilitate intercellular communication by transferring a complex cargo of biologically active molecules to target cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
15 Samples

Download data: CEL

Series

Accession:: GSE102401

ID:: 200102401

Select item 2001714899.

Temperature influences the composition and cytotoxicity of extracellular vesicles in Staphylococcus aureus

(Submitter supplied) Staphylococcus aureus is a pathogenic bacterium but also a commensal of skin and anterior nares in humans. As S. aureus transits from skins/nares to inside the human body, it experiences changes in temperature. The production and content of S. aureus extracellular vesicles (EV) have been increasingly studied over the past few years and EVs are increasingly being recognized as important to the infectious process. more...

Organism:: Staphylococcus aureus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28116
6 Samples

Download data: XLSX

Series

Accession:: GSE171489

ID:: 200171489

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012165210.

Extracellular Vesicle P100 Fraction Small RNAs

(Submitter supplied) Extracellular Vesicles were isolated from primary cultures of neural stem cells (NSCs) and astrocytes by performing serial centrifugation and a 100,000 x g ultracentrifugation step. The goal of this experiment is to compare EV small RNAs from two cell types.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TSV, TXT

Series

Accession:: GSE121652

ID:: 200121652

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20023171511.

Directional endothelial communication by polarized extracellular vesicle release

(Submitter supplied) EVs were isolated from primary human aortic endothelial cells (ECs) (+/- IL-1b activation), quantified, and analysed by miRNA transcriptomics and proteomics. Compared to quiescent ECs, activated ECs increased EV release, with miRNA and protein cargo that were related to atherosclerosis pathways. RNA sequencing of EV-treated monocytes and vascular smooth muscle cells (VSMCs) revealed that EVs from activated ECs altered pathways that were pro-inflammatory and atherogenic.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
18 Samples

Download data: TXT

Series

Accession:: GSE231715

ID:: 200231715

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023029012.

Endothelial cells secrete polarized small extracellular vesicles containing distinct cargo to uniquely reprogram luminal and abluminal vascular cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL24676
36 Samples

Download data

Series

Accession:: GSE230290

ID:: 200230290

PubMed Full text in PMC Similar studies

Select item 20023028913.

Directional endothelial communication by polarized extracellular vesicle release

(Submitter supplied) EVs were isolated from primary human aortic endothelial cells (ECs) (+/- IL-1b activation) grown on transwells, quantified, and analysed by miRNA transcriptomics.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: XLSX

Series

Accession:: GSE230289

ID:: 200230289

PubMed Full text in PMC Similar studies

Select item 20023024614.

Directional endothelial communication by polarized extracellular vesicle release

(Submitter supplied) EVs were isolated from primary human aortic endothelial cells (ECs) (+/- IL-1b activation), quantified, and analysed by miRNA transcriptomics and proteomics.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: XLSX

Series

Accession:: GSE230246

ID:: 200230246

PubMed Full text in PMC Similar studies

Select item 20008997015.

Genome-wide map of HAEC chromatin landscape under resting and TNFa, IL1b, and OxPAPC stimulation, with corresponding transcription factor binding and RNA expression

(Submitter supplied) We report the dynamic enhancer landscape of HAEC at baseline and under inflammatory stimulation, and also show the cistromes of ETS, AP-1 as well as key signal dependent transcription factors, with corresponding gene expression. We also describe the inflammatory transcriptional profile caused by inhibition of the ETS factor ERG with siRNA.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL20301
75 Samples

Download data: TXT

Series

Accession:: GSE89970

ID:: 200089970

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20021656116.

Depletion-assisted multiplexing cell-free RNA sequencing reveals distinct human and microbial signatures in plasma versus extracellular vesicle

(Submitter supplied) Cell-free RNAs in biofluids provide opportunities to monitor cancer in a non-invasive manner. Although extracellular microRNAs are extensively characterized, fragmented cell-free long RNAs are not well investigated. Here, we developed Detector-seq (depletion-assisted multiplexing cell-free total RNA sequencing) to enable the deciphering of the cell-free transcriptome. After demonstrating the superior performance of detecting fragmented cell-free long RNAs, we applied Detector-seq to compare cell-free RNAs in human plasma and its extracellular vesicle (EV). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
113 Samples

Download data: TXT

Series

Accession:: GSE216561

ID:: 200216561

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023437517.

Spleens from mice exposed to either 9 Gy of whole-body ionizing radiation (WBIR) and WBIR combined with a 20% total body surface area burn (RCI) and treated with mouse mesenchymal stem cell derived extracellular vesicles (MSC-EVs)

(Submitter supplied) Mice were treated with 1x1010 MSC-EVs inravenously 72 hours after exposure to 9 Gys of WBIR or RCI. 48 hours later the spleens were isolated from these mice and processed for RNA. This analysis was completed in order to assess the impact of MSC-EV treatment on the immune gene expression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19964
15 Samples

Download data: RCC

Series

Accession:: GSE234375

ID:: 200234375

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023369218.

Nanostring mouse immunology mRNA panel - EVs isolated following exposure to WBIR were exposed onto RAW 264.7

(Submitter supplied) 561 mouse mRNA immunology panel. EVs isolated from mice 3 or 7 days after exposure to 2 or 9 Grays of WBIR and were exposed onto RAW 265.7 macrophages in the presence of LPS in order to assess the gene expression changes in order to analyze the effect of these EVs on the pro-inflammatory response of macrophages. All experimental groups were compared to the exposure of Sham EVs onto macrophages.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19964
15 Samples

Download data: RCC

Series

Accession:: GSE233692

ID:: 200233692

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023368819.

Nanostring mouse miRNA panel: performed on extracellular vesicles isolated following exposure to radiation

(Submitter supplied) Plasma derived extracellular vesicles (EVs) have emerged as critical mediators of complications following traumatic injuries and after exposure to radiation. In response to injury, the cargo of these EVs is altered and can contain potent cargo that can influence cell function, including alterations in miRNA cargo. Here, we utilized NanoString's mouse miRNA panel to compare the alterations in miRNA content following exposure to 2 or 9 Gys of whole-body irradiation isolated 3 days after exposure and compared these changes to sham mice.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL23053
14 Samples

Download data: RCC

Series

Accession:: GSE233688

ID:: 200233688

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024465320.

An integrated toolkit for human microglia functional genomics

(Submitter supplied) Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such as prolonged differentiation time, lack of detailed characterization, and limited gene function investigation via CRISPR-Cas9. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
2 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE244653

ID:: 200244653

PubMed Full text in PMC Similar studies

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from GEO DataSets

Items: 20

Send to:

Supplemental Content

Find related data

Important Links

Recent activity