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Using bone marrow stromal cells as micro-environmental sensors identifies IL-6 and TGFa signalling as regulators of declining erythropoiesis and lymphopoiesis during hematopoietic ageing
PubMed Full text in PMC Similar studies
Bap1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells
Bap1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells [RNA-Seq]
Bap1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells [ChIP-Seq]
Sorted HSCs from aged Specific Pathogen Free and germ free mice
PubMed Full text in PMC Similar studies Analyze with GEO2R
RNA-Seq of PreCFU-E and CFU-E progenitors from wild type and Scf mutants
PubMed Full text in PMC Similar studies SRA Run Selector
Gene expression analysis of primitive erythroid progenitors from 5-FU-treated WT and ESAM-KO mice.
Loss of adrenergic nerves in bone marrow drives hematopoietic stem cell niche aging
Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
PubMed Similar studies SRA Run Selector
Zinc Finger Protein 521 regulates early hematopoiesis through cell extrinsic mechanisms in the bone marrow microenvironment
TGFβ1-mediated functional inhibition of mesenchymal stromal cells in MDS and AML
PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector
EBF-1 mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential
EBF1-mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential [HSC]
EBF1-mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential
Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation
CXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance
Decline in IGF1 in CXCL12-Abundant Reticular (CAR) Cells Causes Myeloid-Biased Hematopoiesis Observed During Aging
PubMed Similar studies
Gene expression analyses of hematopoietic stem cell (HSC) subsets in wildtype or CD41-KO mice
PubMed Similar studies Analyze with GEO2R
Stromal inflammation is a targetable driver of blood aging [droplet-based scRNAseq - Batch 2]
Stromal niche inflammation mediated by IL-1 signaling is a targetable driver of hematopoietic aging
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