Similar studies for GEO DataSets (Select 200107782) - GEO DataSets

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Items: 20

Select item 2001077821.

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL15456 GPL20301 GPL10558
41 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE107782

ID:: 200107782

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001077812.

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [RNA-seq]

(Submitter supplied) EZH2 induces active transcription of the AR gene, thereby increasing AR level and promoting AR signaling. Importantly, EZH2-mediated activation of AR requires EZH2 protein occupancy at the AR gene promoter, but is independent of PRC2 as well as its histone methyltransferase activity

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
8 Samples

Download data: TXT

Series

Accession:: GSE107781

ID:: 200107781

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001077803.

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL15456
9 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE107780

ID:: 200107780

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001077794.

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [microarray]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
24 Samples

Download data: TXT

Series

Accession:: GSE107779

ID:: 200107779

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000624925.

Genome wide analysis of AR binding sites and histone modifications in prostate cancer

(Submitter supplied) Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and histone modifications.In addition, by siRNA mediated knockdown of AR-associated factors, changes of AR-binding sites in prostate cancer cells were analyzed..

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL10999
23 Samples

Download data: BAR, TXT

Series

Accession:: GSE62492

ID:: 200062492

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000624546.

Effects of RUNX1 knockdown in AR signaling

(Submitter supplied) Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified RUNX1 is an androgen-regulated gene. In order to investigate the RUNX1 function in prostate cancer cells, we performed gene expression in AR-positive prostate cancer cell lines after siRUNX1 treatment. We also treated cells with vehicle or androgen to analyzed the effects of RUNX1 on AR function.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5606
Platform:: GPL6244
4 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE62454

ID:: 200062454

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 56067.

Androgen effect on runt-related transcription factor 1-deficient prostate cancer cell line

Analysis of androgen receptor (AR)-positive prostate cancer (PC) LNCaP cells depleted for runt-related transcription factor (RUNX1) by siRUNX1 transfection then treated with 10nM dihydrotestosterone (DHT). Results provide insight into the role of RUNX1 in AR-dependent PC.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL6244
Series:: GSE62454
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5606

ID:: 5606

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001242688.

Polycomb Group Proteins EZH2 and EED Directly Regulate Androgen Receptor in Advanced Prostate Cancer

(Submitter supplied) Polycomb group proteins are important epigenetic regulators for organ development, cell proliferation and differentiation, as well as initiation and progression of lethal diseases, including cancer. Upregulated Polycomb group proteins, including EZH2, promote proliferation, migration, invasion and metastasis of cancer cells, as well as self-renewal of cancer stem cells. The canonical function of EZH2, along with its essential binding partners EED and SUZ12, is to methylate histone H3K27 and repress its downstream targets. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: TXT

Series

Accession:: GSE124268

ID:: 200124268

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2002051079.

A cryptic transactivation domain of EZH2 binds AR and its splice variant promoting oncogene activation and prostate tumorigenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
25 Samples

Download data: BW

Series

Accession:: GSE205107

ID:: 200205107

PubMed Full text in PMC Similar studies

Select item 20020510610.

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant promoting oncogene activation and prostate tumorigenesis [CUT&RUN]

(Submitter supplied) Enhancer of Zeste Homolog 2 (EZH2) and androgen receptor (AR) are both crucial for the development and progression of prostate tumor, including advanced castration-resistant prostate cancer (CRPC). Previously, it was reported that, in order to sustain tumorigenicity of prostate cancer, EZH2 has noncanonical functions in interaction with AR for mediating gene activation, in addition to its canonical role as a transcriptional repressor and enzymatic subunit of Polycomb Repressive Complex 2 (PRC2). more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
13 Samples

Download data: BW

Series

Accession:: GSE205106

ID:: 200205106

PubMed Full text in PMC Similar studies

Select item 20020510511.

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant promoting oncogene activation and prostate tumorigenesis [RNA-Seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: TXT

Series

Accession:: GSE205105

ID:: 200205105

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003946112.

Role of PRC2 complex components in prostate cancer cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL570
24 Samples

Download data: BED, BW, CEL

Series

Accession:: GSE39461

ID:: 200039461

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003945913.

Genome-wide maps of PRC2 complex components and chromatin states in prostate cancer cell lines

(Submitter supplied) We report the high-throughput profiling of PRC2 core subunits chromatin states and histone modifications in two prostate cancer cell lines, androgen-dependent cells LNCaP and androgen-independent cells LNCaP-abl (abl). By obtaining over 1 billion bases of sequence from chromatin immunoprecipitated DNA, we generated the genome-wide localizations of EZH2, SUZ12 and H3K27 trimethylation in both cell lines, and found that EZH2 can be localized to a subsets of chromating sites that don't have H3K27me3 or SUZ12 signals nearby. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: BED, BW

Series

Accession:: GSE39459

ID:: 200039459

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003945214.

Expression data of EZH2-dependent genes in prostate cancer cell lines

(Submitter supplied) EZH2 is frequently over-expressed in aggressive and metastatic solid tumors, including castration resistant prostate cancer (CRPC). We sought to determine EZH2-dependent gene expression programmes in prostate cancer progression, and found an intriguing functional switch of EZH2 from a repressor to an activator during CRPC development. We used microarrays to detail the global profiling of gene expression that are differentially regulated upon EZH2 depletion in two different prostate cancer cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE39452

ID:: 200039452

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004123915.

Gene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of EZH2

(Submitter supplied) We studied transcriptional changes by Affymetrix human microarrays in 2 DLBCL cell lines as a result of shRNA mediated knockdown of EZH2. In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE41239

ID:: 200041239

Select item 20004097216.

EZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL570 GPL9115
52 Samples

Download data: BED, CEL

Series

Accession:: GSE40972

ID:: 200040972

Select item 20004097117.

Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor

(Submitter supplied) We studied transcriptional changes by Affymetrix human microarrays in DLBCL cell lines as a result of treatment with GSK126, a potent, highly-selective, SAM-competitive, small molecule inhibitor of EZH2 In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
40 Samples

Download data: CEL

Series

Accession:: GSE40971

ID:: 200040971

Select item 20004097018.

ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines

(Submitter supplied) In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histone H3 on lysine 27 (H3K27). Over-expression of EZH2 is implicated in tumorigenesis and correlates with poor prognosis in multiple tumor types. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
6 Samples

Download data: BED

Series

Accession:: GSE40970

ID:: 200040970

PubMed Similar studies SRA Run Selector

Select item 20003197819.

Cooperation between Androgen Receptor and Polycomb in oncogenic transformation

(Submitter supplied) Androgen receptor (AR) is a hormone-activated transcription factor that plays important roles in prostate development, function, as well as malignant transformation. The downstream pathways of AR, however, are incompletely understood. AR has been primarily known as a transcriptional activator inducing prostate-specific gene expression. Through integrative analysis of genome-wide AR occupancy and androgen-regulated gene expression, here we report AR as a globally acting transcriptional repressor. more...