Similar studies for GEO DataSets (Select 200097347) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Links from GEO DataSets

Items: 16

Select item 2000973471.

ZBTB18 is a repressor of mesenchymal genes in Glioblastoma [BTSC233]

(Submitter supplied) The transcriptional repressor ZBTB18 was overexpressed in the brain tumor stem cell-like BTSC233 by lentiviral transduction. Three independent transduction were performed (biological replicates) and analyzed by gene expression aray. Gene set enrichemnt analysis (GSEA) showed changes in the expression of mesenchymal signature. A subset of genes was further valiadted by qPCR. These results indicate a role of ZBTB18 as repressor of mesenchymal genes in Glioblastoma.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
6 Samples

Download data: TXT

Series

Accession:: GSE97347

ID:: 200097347

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000973502.

ZBTB18 is a repressor of mesenchymal genes in Glioblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data

Series

Accession:: GSE97350

ID:: 200097350

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000973493.

ZBTB18 is a repressor of mesenchymal genes in Glioblastoma [JX6]

(Submitter supplied) The transcriptional repressor ZBTB18 was overexpressed in the brain tumor xenoline JX6 by lentiviral transduction. Three independent transduction were performed (biological replicates) and analyzed by gene expression aray. Gene set enrichemnt analysis (GSEA) showed changes in the expression of mesenchymal signature. A subset of genes was further valiadted by qPCR. These results indicate a role of ZBTB18 as repressor of mesenchymal genes in Glioblastoma.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
6 Samples

Download data: TXT

Series

Accession:: GSE97349

ID:: 200097349

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000701754.

Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells

(Submitter supplied) Glioblastoma (GBM) is the most common and most aggressive primary brain tumor in adults. The existence of a small population of stem-like tumor cells that efficiently propagate tumors and resist cytotoxic therapy is one proposed mechanism leading to the resilient behavior of tumor cells and poor prognosis. In this study, we performed an in-depth analysis of the DNA methylation landscape in GBM-derived cancer stem cells (GSCs). more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL11154
11 Samples

Download data: BED

Series

Accession:: GSE70175

ID:: 200070175

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000767865.

Annexin 2A sustains glioblastoma cell dissemination and proliferation affecting patient prognosis

(Submitter supplied) Glioblastoma (GBM) is the most devastating tumour of the brain, endowed with a fatal prognosis. Indeed, the complete eradication of cancer cell disseminated outside the GBM mass still remains a crucial issue. Given the reported strong association existing between Annexin 2A (ANXA2) expression and cell dissemination in many cancers, we evaluated the effects exerted by the modulation of ANXA2 levels in GBM cells and assessed its potential in predicting patient outcome. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE76786

ID:: 200076786

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001116526.

Transcriptome analysis of U87 cells upon LINC00152 knockdown

(Submitter supplied) To understand the global changes in genes expression after knockdown of LINC00152, we compared transcriptomes of control cells (treated with siGL2) and LINC00152 knockdown cells (treated with si00152).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: TXT

Series

Accession:: GSE111652

ID:: 200111652

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000042717.

Molecular subclasses of high-grade glioma: prognosis, disease progression, and neurogenesis

(Submitter supplied) Novel prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis. One tumor class displaying neuronal lineage markers shows longer survival, while two tumor classes enriched for neural stem cell markers display equally short survival. Poor prognosis subclasses exhibit either markers of proliferation or of angiogenesis and mesenchyme. Analysis of gene expression data is described in Phillips et al., Cancer Cell, 2006. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS1815 GDS1816
Platforms:: GPL96 GPL97
200 Samples

Download data: CEL, EXP

Series

Accession:: GSE4271

ID:: 200004271

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 18168.

High-grade gliomas (HG-U133B)

Analysis of high-grade glioma (HGGs) samples from cases of WHO grade III and IV astrocytomas. Results classify HGGs into molecular subclasses with prognostic value that predict survival and disease progression. The molecular subclasses resemble key stages of neurogenesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 cell type, 4 disease state, 6 other, 2 specimen sets

Platform:: GPL97
Series:: GSE4271
100 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1816

ID:: 1816

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 18159.

High-grade gliomas (HG-U133A)

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 cell type, 4 disease state, 6 other, 2 specimen sets

Platform:: GPL96
Series:: GSE4271
100 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1815

ID:: 1815

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20008104310.

Silencing of KDM2B leads to deregulation of apoptosis related genes in GBM

(Submitter supplied) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anti-cancer protein that can specifically kill tumor cells while sparing healthy ones. Emerging evidences suggest that TRAIL resistance in cancers is associated with aberrant expression of the key components of the apoptotic program. However, how these components are regulated at the epigenetic level is not understood. In this study, we aimed to identify novel epigenetic mechanisms regulating TRAIL response in Glioblastoma Multiforme (GBM) by a short-hairpin RNA (shRNA) screen. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: XLSX

Series

Accession:: GSE81043

ID:: 200081043

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20014000211.

Genome wide mapping of binding sites of ZBTB18 and CTBP2 in glioblastoma cancer cells

(Submitter supplied) CTBP2 is a transcriptional co-repressor/co-activator palying a role in EMT. We have identified CTBP2 as a protein interacting with ZBTB18, a transcriptional repressor and tumor suppressor in GBM. Here, we have performed genome wide mapping of CTBP2 and ZBTB18 binding sites in GBM to characterized their gene regulation mechanism.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
8 Samples

Download data: BED

Series

Accession:: GSE140002

ID:: 200140002

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013889012.

Genome-wide analysis upon ZBTB18 expression and/or CTBP2 silencing in Glioblastoma

(Submitter supplied) We have identified the CTBP2 protein as a new ZBTB18 interactor. Here we have evaluated transcriptomic changes upon CTBP2 knockdown in the GBM cell line SNB19. Moreover, we have analyzed whether CTBP2 is required for ZBTB18-mediated gene repression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE138890

ID:: 200138890

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000769613.

Glioblastoma from a homogenous cohort of patients treated within clinical trial

(Submitter supplied) Analysis of 80 glioblastoma specimen of patients treated within clinical trials and 4 samples of "normal" brain tissue (non-tumoral). The data was used to identify factors of resistance to a chemoradiation therapy protocol of radiotherapy and concomitant and adjuvant temozolomide (alkylating agent). Keywords: Disease state comparison

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
84 Samples

Download data: CEL

Series

Accession:: GSE7696

ID:: 200007696

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011629814.

Intra-Tumor DNA Methylation Heterogeneity in Glioblastoma; Implications for DNA Methylation-based Classification

(Submitter supplied) Background: A feature of glioblastoma (GBM) is the cellular and molecular heterogeneity, both within and between tumors. This variability results in a risk for sampling bias and potential tumor escape from future targeted therapy. Heterogeneous gene expression within GBM is well documented, but little is known regarding the epigenetic heterogeneity. We therefore aimed to profile the intra-tumor DNA methylation heterogeneity in GBM. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL21145
47 Samples

Download data: IDAT

Series

Accession:: GSE116298

ID:: 200116298

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006241915.

FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma

(Submitter supplied) Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic neuroblastoma cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16876
24 Samples

Download data: TXT

Series

Accession:: GSE62419

ID:: 200062419

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012965716.

The chromatin landscape modified by Zbtb18 in activated B cells

(Submitter supplied) The differentiation of plasma cell is prescisely controlled by the key transcriptional program as well as epigenetic changes. Recently, we have identified, one zinc finger protein, Zbtb18, as a new regulator for B cell differentiation process. To investigate the molecular mechanisms of Zbtb18 during B cell differentiation program we employed the assay for transposase (Tn5) -accessible chromatin followed by deep sequencing (ATAC-Seq) in the sorted Control and Zbtb18 over-expressing B cells (B220+ CD138-) before and after anti-CD40 and IL-4 stimulation. more...