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| Status |
Public on Apr 04, 2017 |
| Title |
ZBTB18 is a repressor of mesenchymal genes in Glioblastoma [JX6] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The transcriptional repressor ZBTB18 was overexpressed in the brain tumor xenoline JX6 by lentiviral transduction. Three independent transduction were performed (biological replicates) and analyzed by gene expression aray. Gene set enrichemnt analysis (GSEA) showed changes in the expression of mesenchymal signature. A subset of genes was further valiadted by qPCR. These results indicate a role of ZBTB18 as repressor of mesenchymal genes in Glioblastoma.
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| |
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| Overall design |
Total RNA extracted from JX6 transduced with pCHMWS-EGFP-FLAG ZBTB18 lentiviral vector (three biological replicates).
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| |
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| Contributor(s) |
Fedele V, Masilamani AP, Carro MS |
| Citation(s) |
28512252 |
| |
| Submission date |
Apr 03, 2017 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Maria Stella Carro |
| E-mail(s) |
maria.carro@uniklinik-freiburg.de
|
| Phone |
0049 76127054400
|
| Organization name |
Freiburg University Medical Center
|
| Lab |
Neuro-oncology
|
| Street address |
Breisacherstraße 64
|
| City |
Freiburg |
| ZIP/Postal code |
79211 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (6)
|
| GSM2562068 |
JX6 transduced with control lentiviral vector 1 |
| GSM2562069 |
JX6 transduced with control lentiviral vector 2 |
| GSM2562070 |
JX6 transduced with control lentiviral vector 3 |
| GSM2562071 |
JX6 transduced with ZBTB18-expressing lentiviral vector 1 |
| GSM2562072 |
JX6 transduced with ZBTB18-expressing lentiviral vector 2 |
| GSM2562073 |
JX6 transduced with ZBTB18-expressing lentiviral vector 3 |
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| This SubSeries is part of SuperSeries: |
| GSE97350 |
ZBTB18 is a repressor of mesenchymal genes in Glioblastoma |
|
| Relations |
| BioProject |
PRJNA381512 |
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