GEO DataSets

(Submitter supplied) Throughout childhood and adolescence, periods of heightened neuroplasticity are critical for the development of healthy brain function and behavior. Given the high prevalence of neurodevelopmental disorders such as autism, identifying disruptors of developmental plasticity represents an essential step for developing strategies for prevention and intervention. Applying a novel computational approach that systematically assessed connections between 436 transcriptional signatures of disease and multiple signatures of neuroplasticity, we identified inflammation as a common pathological process central to a diverse set of diseases predicted to dysregulate plasticity signatures. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

9 Samples

Download data: TXT

(Submitter supplied) A better understanding of how Otx2 regulates plasticity in the visual cortex requires that its non-cell autonomous transcription targets be identified. We dissected layer IV of the visual cortex and used RNA-sequencing to analyze gene expression at postnatal day 30 (P30) and P100 in wild-type (WT) and Otx2+/GFP heterozygotes mice. The rationale is that CP plasticity is opened at P30 in WT but not in Otx2+/GFP mice, given that genetic deletion delays CP opening (Sugiyama et al., 2008), and that the CP is closed at P100 in WT mice and not yet in Otx2+/GFP mice. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL13112 GPL15103

8 Samples

Download data: TXT, XLSX

(Submitter supplied) Analysis of gene expression before (P14), during (P28), and after (P60) the critical period for ocular dominance plasticity. Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3375 GDS3376 GDS3382

Platforms:

GPL83 GPL81 GPL82

30 Samples

Download data: CEL, CHP

Analysis of visual cortices before the critical period for ocular dominance plasticity opens [postnatal day 14 (P14)], at the peak sensitivity of the critical period (P28), and after the critical period (P60). Results provide insight into the molecular mechanisms associated with the critical period.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL83

Series:

GSE11764

10 Samples

Download data: CEL, CHP

Analysis of visual cortices before the critical period for ocular dominance plasticity opens [postnatal day 14 (P14)], at the peak sensitivity of the critical period (P28), and after the critical period (P60). Results provide insight into the molecular mechanisms associated with the critical period.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL82

Series:

GSE11764

10 Samples

Download data: CEL, CHP

Analysis of visual cortices before the critical period for ocular dominance plasticity opens [postnatal day 14 (P14)], at the peak sensitivity of the critical period (P28), and after the critical period (P60). Results provide insight into the molecular mechanisms associated with the critical period.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL81

Series:

GSE11764

10 Samples

Download data: CEL, CHP

(Submitter supplied) Visual deprivation, either in the form of dark rearing (DR) or monocular deprivation (MD) are established paradigms for studying cortical plasticity. We have used miRNA microarray to uncover miRNAs whose expression is altered in primary visual cortex following DR and/or MD.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL10384

9 Samples

Download data: TXT