GEO DataSets

(Submitter supplied) The C57BL/6J mouse model develops obesity and pre-diabetes when fed a high-fat diet. In this experiment, DNA methylation was assessed globally at specific CpG sites in liver tissue from mice receiving high-fat diet (45E% from fat) for 13 weeks (Control) or high-fat diet supplemented with 20% (w/w) of freeze-dried lingonberries (n=4). Our findings show that lingonberries prevent development of high-fat induced obesity, hepatic steatosis and low-grade inflammation, and the DNA was hypermethylated in mice receiving lingonberries compared to control.

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL17021

8 Samples

Download data: TXT

(Submitter supplied) Time-course analysis of adipocyte gene expression profiles response to high fat diet. The hypothesis tested in the present study was that in diet-induced obesity, early activation of TLR-mediated inflammatory signaling cascades by CD antigen genes, leads to increased expression of pro-inflammatory cytokines and chemokines, resulting in chronic low-grade inflammation. Early changes in collagen genes may trigger the accumulation of ECM components, promoting fibrosis in the later stages of diet-induced obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS6247 GDS6248

Platform:

GPL6887

91 Samples

Download data: TXT

Analysis of livers of C57BL/6J mice fed a high fat diet for up to 24 weeks. Significant body weight gain was observed after 4 weeks. Results provide insight into the effect of high fat diets on metabolism in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol, 9 time sets

Platform:

GPL6887

Series:

GSE39549

51 Samples

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Analysis of epididymal and mesenteric white adipose tissues (WAT) of mice fed a high fat diet for up to 24 weeks. Excessive fat accumulation was evident in visceral WAT depots after 4 weeks. Results provide insight into the molecular events that occur during the development of diet-induced obesity.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol, 5 time, 2 tissue sets

Platform:

GPL6887

Series:

GSE39549

40 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL13112

27 Samples

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(Submitter supplied) Publication Title: DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet. It is now well established that an intrauterine environment altered by overnutrition or malnutrition can change gene expression patterns through epigenetic mechanisms that may persist through generations. However, it is less clear if overnutrition alters epigenetic control of gene expression in adults, or if whether such mechanisms contribute to the pathology of obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

14 Samples

Download data: CSV, TXT

(Submitter supplied) Publication Title: DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet. It is now well established that an intrauterine environment altered by overnutrition or malnutrition can change gene expression patterns through epigenetic mechanisms that may persist through generations. However, it is less clear if overnutrition alters epigenetic control of gene expression in adults, or if whether such mechanisms contribute to the pathology of obesity. more...

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL13112

13 Samples

Download data: TXT

(Submitter supplied) We studied the effect of dietary fat type, varying in polyunsaturated/saturated fatty acid ratio's (P/S) on development of metabolic syndrome. C57Bl/6J mice were fed purified high-fat diets (45E% fat) containing palm oil (HF-PO; P/S 0.4), olive oil (HF-OO; P/S 1.1) or safflower oil (HF-SO; P/S 7.8) for 8 weeks. A low-fat palm oil diet (LF-PO; 10E% fat) was used as a reference. Additionally, we analyzed diet-induced changes in gut microbiota composition and mucosal gene expression. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4339

Platform:

GPL1261

9 Samples

Download data: CEL

Analysis of small intestine divided into 3 equal parts along the proximal to distal axis (SI 1, SI 2, SI 3) from C57Bl/6J males fed high-fat diets varying in polyunsaturated/saturated fatty acid ratios (P/S). Results provide insight into role of dietary fat type on development of metabolic syndrome.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent, 3 tissue sets

Platform:

GPL1261

Series:

GSE18586

9 Samples

Download data: CEL

(Submitter supplied) Fast food diet consumption and sedentary life style leads to energy excess, which elevates risks for obesity, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and cancer. Exercise training conveys many health benefits in populations with or without these chronic conditions. Diet and exercise regulate gene expression by mediating epigenetic mechanisms globally and at select loci in an array of human tissues, however, such effects are less well documented in liver tissue. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:

GPL13112 GPL17021

38 Samples

Download data: TXT

(Submitter supplied) High fat diet (HF) rodent models have contributed significantly to the dissection of the pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly between different studies. Here, we have analyzed gene expression patterns in livers of animals fed with different HF with varying fatty acid compositions. Keywords: diet-gene interaction

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1307

Platform:

GPL1355

10 Samples

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Expression profiling of liver from Wistar males fed for 12 weeks with one of 4 different high fat diets, each differing in fatty acid composition. The different fat sources used were lard, olive oil, coconut fat, and cod liver oil.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 protocol sets

Platform:

GPL1355

Series:

GSE3512

10 Samples

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(Submitter supplied) Exposure to a prenatal high fat (HF) diet leads to an impaired metabolic phenotype in mouse offspring. The underlying mechanisms, however, are not yet fully understood. Therefore, this study investigated whether the impaired metabolic phenotype could have been mediated through altered hepatic DNA methylation and gene expression. In this study, both parent mice received a HF or low fat (LF) diet before and during pregnancy, and throughout lactation, after which offspring was weaned onto a HF diet. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20837

32 Samples

Download data: CEL, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Methylation profiling by genome tiling array

Platforms:

GPL21389 GPL21388

8 Samples

Download data: CALLS, PAIR, TXT, WIG

(Submitter supplied) Exposure to a high fat (HF) diet in utero is associated with increased incidence of cardiovascular disease, diabetes and metabolic syndrome later in life. However, the molecular basis of this enhanced susceptibility for metabolic disease is poorly understood. We used gene expression microarray to examine mRNA expression patterns in liver of offspring exposed to a Control or HF maternal diet. WT mice were fed a Control (9.5% fat, 3.59 kcal/g) or HF (35.5% fat, 5.29 kcal/g) diet for 2 wk before mating, throughout pregnancy and lactation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21389

2 Samples

Download data: CALLS, PAIR

(Submitter supplied) Exposure to a high fat (HF) diet in utero is associated with increased incidence of cardiovascular disease, diabetes and metabolic syndrome later in life. However, the molecular basis of this enhanced susceptibility for metabolic disease is poorly understood. We performed genome-wide DNA methylation analysis to examine DNA methylation patterns in liver of offspring exposed to a Control or HF maternal diet. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL21388

6 Samples

Download data: TXT, WIG

(Submitter supplied) Knockin mice were created that contained a point mutation that elminated the requisite GT in the 5' donor site of each of the NCoRω or NCoRδ splice variants, thus preventing splicing at that site and forcing splicing of the reciprocal splice variant.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

22 Samples

Download data: TXT

(Submitter supplied) We identified differentially methylated regions across the genome in the liver associated with a high-fat diet. Grant: Funding source: American Heart Association Grant number: 16PRE26420105 Title: The effect of maternal over-nutrition on obesity, epigenetics, and gene expression Awarded to Madeline Keleher

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL19057

16 Samples

Download data: BED

(Submitter supplied) We identified 4,356 genes with expression differences associated with a high-fat diet, with 184 genes exhibiting a sex-by-diet interaction. Dietary fat dysregulated several pathways, such as cytokine-cytokine receptor interaction, chemokine signaling, and oxidative phosphorylation. Grant: Funding source: American Heart Association Grant number: 16PRE26420105 Title: The effect of maternal over-nutrition on obesity, epigenetics, and gene expression Awarded to Madeline Keleher

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

21 Samples

Download data: TXT

(Submitter supplied) We exposed three mouse strains to a high-fat high-carbohydrate diet, leading to varying degrees of metabolic syndrome. Comprehensive methylation and transcriptomic analysis found overlapping but also highly divergent changes in DNA methylation and gene expression, with pathway analysis suggesting a strategy for strain-specific targeted pharmacologic intervention of upstream regulators. Administeration of the drug GW4064 to target one of these genotype-dependent networks, the farnesoid X receptor pathway resulted in genotype-specific protection against dietary effects in BL6 as predicted by our epigenetic analysis.

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL24247 GPL21103

96 Samples

Download data: TSV, TXT