GEO DataSets

(Submitter supplied) The study consists of three parts: 1) normal aging in liver and skin (cross-sectional); 2) treatment with rotenone in brain, liver and skin; 3) longitudinal study of 45 fish with different ages at their death measured at two different time points by fin clipping Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17944 GPL19871

185 Samples

Download data: TXT

(Submitter supplied) Here, we performed a longitudinal study of genome-wide gene expression in the short-lived killifish Nothobranchius furzeri (MZM-0410 strain) and correlated variations in transcript abundance at two time points during early adult life with age at death.

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19871

228 Samples

Download data: CSV

(Submitter supplied) Comparison of temporal gene expression profiles. The RNA-seq data comprises different strains (GRZ and MZM-0410) and different ages

Organism:

Nothobranchius furzeri

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL19871

16 Samples

Download data: CSV

(Submitter supplied) Comparison of temporal gene expression profiles. The RNA-seq data comprises different strains (GRZ and MZM-0410) and different ages.

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19871

16 Samples

Download data: TXT

(Submitter supplied) Comparison of gene expression and ribosome profiles from Nothobranchius furzeri brain of 2 age groups. The RNA-seq and ART-seq data comprise 2 groups: 6 and 26 weeks. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL19871

16 Samples

Download data: CSV, XLS

(Submitter supplied) The study consists of 12 samples of 39-week-old N. furzeri (skin and brain). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19871

12 Samples

Download data: TXT

(Submitter supplied) The RNA-seq data contain 3 tissues (brain, liver, skin) of N.furzeri GRZ Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17944

15 Samples

Download data: XLS

(Submitter supplied) Zebrafish of two different age groups (12 and 36 months) were treated with low amounts of rotenone (mild stress) and compared to untreated zebrafish. Two different durations were used (3 and 8 weeks). Illumina sequencing (HiSeq2000) was applied to generate 50bp single-end reads. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14875

68 Samples

Download data: XLS

(Submitter supplied) Background: Comparison of temporal gene expression profiles The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17944

25 Samples

Download data: XLS

(Submitter supplied) small RNA-seq of embryonic samples of N. furzeri.

Organism:

Nothobranchius furzeri

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL19871

7 Samples

Download data: TXT

(Submitter supplied) The RNA-seq data contain 3 tissues (brain, liver, skin) of N. furzeri strains MZM-0410 and GRZ plus 2 biological replicates of brain of 6 other killifish species. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Iconisemion striatum; Nothobranchius furzeri; Nothobranchius pienaari; Nothobranchius kadleci; Nothobranchius rachovii; Nothobranchius kuhntae; Nothobranchius korthausae

Type:

Non-coding RNA profiling by high throughput sequencing

7 related Platforms

162 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Nothobranchius kadleci; Nothobranchius rachovii; Iconisemion striatum; Nothobranchius furzeri; Nothobranchius kuhntae; Nothobranchius pienaari; Nothobranchius korthausae

Type:

Non-coding RNA profiling by high throughput sequencing

7 related Platforms

169 Samples

Download data: TXT

(Submitter supplied) To investigate the connection between changes of mRNA and protein expression in the brain during aging, we compared the transcriptome and proteome of the mouse cortex. We profiled gene expression in the mouse cortex using data obtained from RNA-seq of three individuals at 6-months old and three individuals at 24-months old.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Aphyosemion australe; Iconisemion striatum; Nothobranchius furzeri; Austrofundulus limnaeus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

8 related Platforms

175 Samples

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(Submitter supplied) We evaluate the global chromatin changes that occur during the developmental progression and development-to-diapause transition in a closely related set of killifish species.

Organism:

Aphyosemion australe; Nothobranchius furzeri; Austrofundulus limnaeus; Iconisemion striatum

Type:

Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms

30 Samples

Download data: TXT

(Submitter supplied) We evaluate the global gene expression changes that occur during a stage-matched developmental window in a closely related set of killifish species.

Organism:

Nothobranchius furzeri; Aphyosemion australe; Iconisemion striatum

Type:

Expression profiling by high throughput sequencing

4 related Platforms

145 Samples

Download data: CSV

(Submitter supplied) Ribosome assembly occurs mainly in the nucleolus yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report a physical and functional interaction between locally synthesized RPs and ribosomes in the axon. We show that axonal RP translation is regulated through a novel sequence motif, CUIC, that forms an RNA-loop structure in the region immediately upstream of the initiation codon. more...

Organism:

Xenopus laevis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21248

2 Samples

Download data: TXT

(Submitter supplied) Local mRNA translation mediates the adaptive responses of axons to extrinsic signals but direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequencing analysis of ribosome-bound mRNAs in the retinal ganglion cell axons of the developing and adult retinotectal projection in vivo. The embryonic-to-postnatal axonal translatome comprises an evolving subset of enriched genes with axon-specific roles suggesting distinct steps in axon wiring, such as elongation, pruning and synaptogenesis. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19057 GPL13112

28 Samples

Download data: TXT, WIG

(Submitter supplied) A vast body of studies is available that describes age-dependent gene expression in relationship to aging in a number of different model species. These data were obtained from animals kept in conditions with reduced environmental challenges, abundant food and deprivation of natural sensory stimulation. Here we compared wild- and captive-aging in the short-lived turquoise killifish (Nothobranchius furzeri). more...

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19871

24 Samples

Download data: XLS

(Submitter supplied) Emerging studies have linked the ribosome to more selective control of gene regulation. However, an outstanding question is whether ribosome heterogeneity at the level of core ribosomal proteins (RPs) enables ribosomes to preferentially translate specific mRNAs genome-wide. Here, we measured the absolute abundance of RPs in translating ribosomes and profiled transcripts that are enriched or depleted from select subsets of ribosomes within embryonic stem cells. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL19057

20 Samples

Download data: TXT