GEO DataSets

(Submitter supplied) Total RNA obtained from human fasted subcutaneous abdominal adipose tissue (FAT) was used to measure genome-wide gene expression. Expression values which were significantly present were standardized by quantile normalization and correlated with clinical data.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

64 Samples

Download data: TXT

(Submitter supplied) Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no specific defect responsible for insulin resistance and DM has been identified in humans. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

20 Samples

Download data: CEL

(Submitter supplied) We sequenced mRNA from subcuteneous adipose tissue of 36 pigs (12 Low, 12 Mean and 12 High) to investigate expression profiling of obesity (porcine model). Uploaded RNAseq data on the first 12 samples (from titles 1_SusScrofa to 12_SusScrofa) are LOW obese pigs, the middle 12 samples (from titles 13_SusScrofa to 24_SusScrofa) are MEDIUM obese pigs and the last 12 samples (from titles 24_SusScrofa to 36_SusScrofa) are HIGH obese pigs. more...

Organism:

Sus scrofa

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19176

36 Samples

Download data: CSV

(Submitter supplied) Transcriptional Profiling of Insulin Sensitive and Insulin Resistant Samples

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

62 Samples

Download data: TXT

(Submitter supplied) The annotation of the Affymetrix HTA 2.0 array was updated to optimise the detection of RNA in human skeletal muscle biopsy samples by removing invalid and low signal-high-variance probes (as for CDF GPL24047). The probes were then summarized into groups (probe-sets) reflecting either an ensembl full transcript identifier (FL-ENST, GPL24047) or just the probes targeting the 3' UTR or the 5' UTR of that particular ENST. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL28993

230 Samples

Download data: CEL

(Submitter supplied) The annotation of the Affymetrix HTA 2.0 array was updated to optimise the detection of RNA in human skeletal muscle biopsy samples by removing invalid and low signal-high-variance probes (as for CDF GPL24047). The probes were then summarized into groups (probe-sets) reflecting either an ensembl full transcript identifier (FL-ENST, GPL24047) or just the probes targeting the 3' UTR or the 5' UTR of that particular ENST. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL28991

230 Samples

Download data: CEL

(Submitter supplied) The annotation of the Affymetrix HTA 2.0 array was updated to optimise the detection of RNA in human skeletal muscle biopsy samples by removing invalid and low signal-high-variance probes (as for CDF GPL24047). The probes were then summarized into groups (probe-sets) reflecting either an ensembl full transcript identifier (FL-ENST, GPL24047) or just the probes targeting the 3' UTR or the 5' UTR of that particular ENST. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24047

230 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

1531 Samples

Download data: CEL

(Submitter supplied) The annotation of the Affymetrix HTA 2.0 array was updated to optimise the detection of both coding and non-coding RNA in human skeletal muscle biopsy samples by removing invalid and low signal-high-variance probes. A transcript level CDF specific to skeletal muscle is provided to use within the standard aroma.affymetrix pipeline.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24047

527 Samples

Download data: CEL

(Submitter supplied) The aim of this work was to compare the effects of AT, RT, and the full combination (AT/RT) on central ectopic fat, liver enzymes, and fasting insulin resistance [homeostatic model assessment (HOMA)]

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

125 Samples

Download data: CEL

(Submitter supplied) The aim of this work was to produce a molecular signature of human muscle responses to supervised resistance training and examine how such a profile relates to established aerobic exercise adaptation gene networks.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

89 Samples

Download data: CEL

(Submitter supplied) The overall objective of the heritage project is to study the role of the genotype in cardiovascular,metabolic and hormonal responses to aerobic exercise training and the contribution of regular exercise to changes in several cardiovascular disease and diabetes risk factors. PLEASE NOTE THE POST-TRAINING GENE CHIP FILES HAVE NEVER BEEN RELEASED ON GEO. PLEASE ALSO NOTE THAT DUE TO THE OUTDATED INSULIN ASSAY UTILISED IN THE HERITAGE STUDY, THE INSULIN DATA WAS NOT COMPARABLE WITH ANY MORE RECENT MODERN STUDIES.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

52 Samples

Download data: CEL

(Submitter supplied) We have identified molecular-level alternations in different adipose depots (thigh, visceral and subcutaneous) of Asian Indians (both male and female) suffering from type-2 diabetes as compared to age and BMI matched normal glucose tolerant subjects by functional analysis of differentially expressed genes, and correlation of gene expression estimates with measured intermediate traits associated with T2D and its related co-morbidities (Hb1Ac, HOMA-B, HOMA-R, NEFA, Triglyceride, Total Cholesterol, HDL, LDL, VLDL, Leptin, Adiponectin, TNF-α, Serum- Creatinine, IL-6, High sensitivity - serum-creatinine (hs-CRP) and also size of adipocytes). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

130 Samples

Download data: CEL, TXT

(Submitter supplied) We analyzed the expression of 23,720 transcripts in the adipose tissue of 701 individuals and the blood of 1021 individuals. Keywords: microarray profiling, genetics, gene expression

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3991

1722 Samples

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(Submitter supplied) Oligonucleotide array on glass. Contains 60mer probes designed against 23,000+ human genes arrayed on Agilent ink-jet arrays. Protocol: see manufacturer's website

Organism:

Homo sapiens

13 Series

2396 Samples

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(Submitter supplied) Adipose tissues play an important role in the pathophysiology of obesity-related disease including type 2 diabetes. To describe gene expression patterns and functional pathways in obesity-related type 2 diabetes, we performed global transcript profiling of omental adipose tissue in morbidly obese individuals with or without diabetes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

20 Samples

Download data: CEL, CHP

(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL3562 GPL4865 GPL3677

96 Samples

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(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

16 Samples

Download data: TXT

(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

10 Samples

Download data: TXT

(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

8 Samples

Download data: TXT