GEO DataSets

(Submitter supplied) Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney and brain of 33 diverse species of mammals. more...

Organism:

Tadarida brasiliensis; Ursus americanus; Meles meles; Equus caballus; Mesocricetus auratus; Meriones unguiculatus; Chlorocebus aethiops; Felis catus; Bos taurus; Capra hircus; Oryctolagus cuniculus; Rattus norvegicus; Sus scrofa; Mus musculus; Petaurus breviceps; Murina leucogaster; Erinaceus europaeus; Suncus murinus; Canis lupus familiaris; Peromyscus leucopus; Acomys cahirinus; Cavia porcellus; Tamias sibiricus

Type:

Expression profiling by high throughput sequencing

23 related Platforms

141 Samples

Download data: GTF, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Papio anubis; Ursus americanus; Petaurus breviceps; Castor canadensis; Macaca fascicularis; Mus musculus; Murina leucogaster; Peromyscus leucopus; Tamias sibiricus

Type:

Expression profiling by high throughput sequencing

9 related Platforms

90 Samples

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(Submitter supplied) Lifespan varies both within and across species, but the general principles of its control are not understood. To identify transcriptomic signatures of mammalian longevity, we sequenced multiple organs of young adult mammals corresponding to 8 different species, including Canadian beaver, long-tailed macaque, greater tube-nosed bat, baboon, white-footed mouse, sugar glider, Siberian chipmunk and American black bear. more...

Organism:

Macaca fascicularis; Petaurus breviceps; Murina leucogaster; Castor canadensis; Papio anubis; Ursus americanus; Peromyscus leucopus; Tamias sibiricus

Type:

Expression profiling by high throughput sequencing

8 related Platforms

48 Samples

Download data: CSV

(Submitter supplied) This dataset consists of liver and kidney gene expression profiles of young UM-HET3 mice subjected to the following compounds for 1 month: AS-703026 (liver and kidney), enzastaurin (liver and kidney), GDC-0941 (liver and kidney), ascorbyl-palmitate (kidney), AZD8055 (kidney) and KU0063794 (kidney). Corresponding age-, sex- and strain-matched littermate controls for kidney are also presented. This dataset complements liver RNAseq profiles of control UM-HET3 mice and mice subjected to ascorbyl-palmitate, AZD8055 and KU0063794 (collected and sequenced at the same time) stored at GSE131868.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

42 Samples

Download data: CSV

(Submitter supplied) We used blood samples from Macaque to determine rate of change of methylation with respect to age.

Organism:

Homo sapiens; Macaca mulatta

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

6 Samples

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(Submitter supplied) We used liver samples from TC1 Mice to determine rate of change of methylation with respect to age.

Organism:

Mus musculus; Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

6 Samples

Download data: TXT

(Submitter supplied) We used liver samples from Naked Mole Rat to determine rate of change of methylation with respect to age.

Organism:

Heterocephalus glaber

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL24046

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Heterocephalus glaber; Homo sapiens; Canis lupus familiaris; Macaca mulatta

Type:

Methylation profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:

GPL24046 GPL13534 GPL22370

84 Samples

Download data: TXT

(Submitter supplied) We used buccal samples from two different dog breeds with well established differences in average lifespan to perform genome-scale identification of ageing-associated differentially methylated positions (aDMPs) in a total of 48 different dogs. A significant proportion of aDMPs that gained methylation with age replicated in an independent cohort. Furthermore, we also show that human aDMPs show similar ageing-associated dynamics at the homologous genomic regions in the dog. more...

Organism:

Canis lupus familiaris

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL22370

48 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus; Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18694 GPL21195

18 Samples

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(Submitter supplied) Comparison of gene expression level by Illumina sequencing of naked mole-rat liver from young and old animals. We identified differentially expressed genes and provide functional profiles, which give insights into the aging process of long-lived rodents.

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21195

9 Samples

Download data: XLS

(Submitter supplied) Caloric restriction (CR) is the only non-genetic intervention to retard aging and increase longevity in a variety of species. It is important to understand the fundamental mechanism by which CR extends lifespan that remains elusive. Owing to well-established genomic tools and convenience of culture system, we used a single cell organism, Saccharomyces cerevisiae, to clarify the mechanisms of CR. In order to identify genes responsible for CR-mediated longevity, we performed microarray experiments across the longevity assurance time-points.

Organism:

Schizosaccharomyces pombe; Saccharomyces cerevisiae BY4741; Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL2529

24 Samples

Download data: CEL, CHP

(Submitter supplied) The study consists of three parts: 1) normal aging in liver and skin (cross-sectional); 2) treatment with rotenone in brain, liver and skin; 3) longitudinal study of 45 fish with different ages at their death measured at two different time points by fin clipping Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17944 GPL19871

185 Samples

Download data: TXT

(Submitter supplied) Zebrafish of two different age groups (12 and 36 months) were treated with low amounts of rotenone (mild stress) and compared to untreated zebrafish. Two different durations were used (3 and 8 weeks). Illumina sequencing (HiSeq2000) was applied to generate 50bp single-end reads. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14875

68 Samples

Download data: XLS

(Submitter supplied) Background: Comparison of temporal gene expression profiles The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Nothobranchius furzeri

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17944

25 Samples

Download data: XLS

(Submitter supplied) Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with expression levels negatively or positively correlated with a species' maximum lifespan (Neg- or Pos-MLS genes). Neg-MLS genes are primarily involved in energy metabolism and inflammation. Pos-MLS genes show enrichment in DNA repair, microtubule organization, and RNA transport. more...

Organism:

Mesocricetus auratus; Mus musculus; Sciurus carolinensis; Tamias striatus; Neotoma cinerea; Condylura cristata; Fukomys damarensis; Peromyscus maniculatus; Ondatra zibethicus; Hydrochoerus hydrochaeris; Ellobius lutescens; Cuniculus paca; Cricetulus barabensis; Blarina brevicauda; Tamiasciurus hudsonicus; Rattus rattus; Myocastor coypus; Heterocephalus glaber; Castor canadensis; Acomys russatus; Marmota monax; Cavia porcellus; Octodon degus; Chinchilla lanigera; Scalopus aquaticus

Type:

Expression profiling by high throughput sequencing

25 related Platforms

522 Samples

Download data: TXT