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Series GSE43013 Query DataSets for GSE43013
Status Public on Feb 17, 2015
Title Gene Expression Defines Natural Changes in Mammalian Lifespan
Organisms Erinaceus europaeus; Suncus murinus; Tadarida brasiliensis; Chlorocebus aethiops; Canis lupus familiaris; Ursus americanus; Meles meles; Felis catus; Equus caballus; Sus scrofa; Bos taurus; Capra hircus; Oryctolagus cuniculus; Mesocricetus auratus; Peromyscus leucopus; Meriones unguiculatus; Acomys cahirinus; Mus musculus; Rattus norvegicus; Cavia porcellus; Petaurus breviceps; Tamias sibiricus; Murina leucogaster
Experiment type Expression profiling by high throughput sequencing
Summary Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life history traits, and identified the processes and pathways involved. These findings provide direct insights into how Nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages.
Overall design RNA-seq gene expression profiling in normal liver, kidney and brain of 33 mammalian species.
Contributor(s) Fushan AA, Turanov AA, Lee SG, Kim EB, Lobanov AV, Yim SH, Gladyshev VN
Citation(s) 25677554
Submission date Dec 19, 2012
Last update date May 15, 2019
Contact name Alexey Fushan
Organization name EWHA
Street address 52, Ewhayeodae-gil
City Seoul
State/province Seodaemun-gu
ZIP/Postal code 120-750
Country South Korea
Platforms (23)
GPL10669 Illumina Genome Analyzer IIx (Rattus norvegicus)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
GPL13765 Illumina Genome Analyzer IIx (Canis lupus familiaris)
Samples (141)
BioProject PRJNA184055
SRA SRP017611

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43013_RAW.tar 16.6 Mb (http)(custom) TAR (of TXT)
GSE43013_chi.rna.gtf.gz 6.7 Mb (ftp)(http) GTF
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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