Similar studies for GEO DataSets (Select 200020958) - GEO DataSets

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Items: 20

Select item 2000209581.

Polycomb Group Protein Bmi1 Promotes Hematopoietic Cell Development from ES Cells

(Submitter supplied) Bmi1 is a component of the Polycomb-repressive complexes (PRC) and essential for maintaining the pool of adult stem cells. PRC are key regulators for embryonic development by modifying chromatin architecture and maintaining gene repression. To assess the role of Bmi1 in pluripotent stem cells and upon exit from pluripotency during differentiation, we studied forced Bmi1 expression in mouse embryonic stem cells (ESC). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4211
Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE20958

ID:: 200020958

Select item 42112.

Polycomb repressive complex 1 protein Bmi1 transduced CCE embryonic stem cells and differentiated embryoid body samples

Analysis of Bmi1 transduced CCE embryonic stem cells (ESC) and CCE ESC differentiated by embryoid body assay. Bmi1 is essential for maintaining the pool of adult stem cells. Results provide insight into role of Bmi1 in ESC-derived hematopoietic cell transition from pluripotency to differentiation.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 5 genotype/variation sets

Platform:: GPL1261
Series:: GSE20958
8 Samples

Download data: CEL

DataSet

Accession:: GDS4211

ID:: 4211

Select item 2000197963.

Expression data from Bmi1-null c-Kit+Sca-1+Lineage marker- (KSL) hematopoietic stem/progenitor cells

(Submitter supplied) Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf 14. Deletion of both Ink4a and Arf in Bmi1-deficient mice substantially restored the defective self-renewal capacity of HSCs and neural stem cells.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
7 Samples

Download data: CEL, CHP

Series

Accession:: GSE19796

ID:: 200019796

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000310864.

Expression data from Bmi1-null common myeloid progenitor (CMP)

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE31086

ID:: 200031086

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000314045.

Expression profiling of LSK cells from Bmi1 cKO mice in hematopoiesis versus LSK control cells from WT mice

(Submitter supplied) Bmi1 is a protein member of PRC1 and plays a major role in the maintenance of gene repression. We are studying the role of Bmi1 in the context of hematopoietic stem cell aging. We used microarray to study the gene expression profile of LSK cells in relation to the knocking-out of Bmi1 in vivo

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
5 Samples

Download data: PDF, TXT, XLS

Series

Accession:: GSE31404

ID:: 200031404

Select item 2000316076.

Transcriptomic analysis of Bmi1 overexpression in NSPC.

(Submitter supplied) We have previously shown that conditional overexpression of Bmi1 in NSC increases their proliferation both in the developing neocortexand in the postnatal brain (Yadirgi et al. 2011). However, during embryonic development, increased and ectopic proliferation induced by overexpression of Bmi1 in progenitors committed toward a neuronal lineage triggered apoptosis, leading eventually to a reduced overall brain size (Yadirgi et al. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
4 Samples

Download data: TXT

Series

Accession:: GSE31607

ID:: 200031607

Select item 2000446087.

Gene expression data from mouse ES cell-derived primitive NSCs and definitive NSCs

(Submitter supplied) Primitive neural stem cells (NSCs) could be derived from pluripotent mouse embryonic stem (ES) cells, and then differentiate into definitive-type neural stem cells which resemble NSCs obtained from the central nervous system. Hence, primitive NSCs define an early stage of neural induction and provide a model to understand the mechanism that controls initial neural commitment. In this study, we performed microarray assay to analyze the global transcriptional profiles in mouse ES cell-derived primitive and definitive NSCs and to depict the molecular changes during the multi-staged neural differentiation process.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
10 Samples

Download data: CEL

Series

Accession:: GSE44608

ID:: 200044608

Select item 2000283258.

Polycomb-like 3 is a PRC2 component that supports embryonic stem cell self-renewal

(Submitter supplied) Polycomb repressive complex 2 (PRC2) trimethylates lysine 27 of histone H3 (H3K27me3), which regulates gene expression and controls diverse biological transitions in development, embryonic stem cell (ESC) differentiation, and cancer. Here we show that Polycomb-like 3 (Pcl3) is a component of PRC2 that promotes H3K27 trimethylation in ESCs. Chromatin immunoprecipitation and sequencing (ChIP-seq) revealed that Pcl3 co-localizes and recruits Suz12 to CpG islands. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9250
10 Samples

Download data: BAM, BED

Series

Accession:: GSE28325

ID:: 200028325

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001212909.

Bmi1 suppresses adipogenesis in the hematopoietic stem cell niche

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
24 Samples

Download data: BEDGRAPH

Series

Accession:: GSE121290

ID:: 200121290

PubMed Full text in PMC Similar studies

Select item 20012128810.

Bmi1 suppresses adipogenesis in the hematopoietic stem cell niche: RNA-Seq

(Submitter supplied) Bone marrow mesenchymal stromal cells (MSCs) that express high levels of stem cell factor (SCF) and CXC chemokine ligand 12 (CXCL12) are one crucial component of the hematopoietic stem cell (HSC) niche. While the secreted factors produced by MSCs to support HSCs have been well described, little is known regarding the transcriptional regulators controlling the cell fate of MSCs and thus indirectly maintaining HSCs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: CSV

Series

Accession:: GSE121288

ID:: 200121288

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013399611.

GATA2 promotes hematopoietic development and represses cardiac differentiation of human mesoderm

(Submitter supplied) In vertebrates, GATA2 is a master regulator of hematopoiesis and is expressed throughout embryo development and in adult life. Although the essential role of GATA2 for the onset of mouse hematopoiesis is well established, its involvement during early human hematopoietic development is not clear. By combining time-controlled overexpression of GATA2 with genetic knockout experiments, we found that GATA2, at the mesoderm specification stage, promotes the generation of hemogenic progenitors and their further differentiation to hematopoietic progenitor cells, while negatively regulating cardiac differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
480 Samples

Download data: TSV

Series

Accession:: GSE133996

ID:: 200133996

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011898012.

GATA2 promotes hematopoietic development and represses cardiac differentiation of human mesoderm

(Submitter supplied) In vertebrates, GATA2 is a master regulator of hematopoiesis and is expressed throughout embryo development and in adult life. Although the essential role of GATA2 in mouse hematopoiesis is well established, its involvement during early human hematopoietic development is not clear. By combining time-controlled overexpression of GATA2 with genetic knockout experiments, we found that GATA2, at the mesoderm specification stage, promotes the generation of hemogenic endothelial progenitors and their further differentiation to hematopoietic progenitor cells, and negatively regulates cardiac differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
18 Samples

Download data: TXT

Series

Accession:: GSE118980

ID:: 200118980

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010763913.

Genome-wide mapping of GATA2 in human iPS

(Submitter supplied) Genome-wide mapping of GATA2 in human iPS

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE107639

ID:: 200107639

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005612614.

PCGF6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ES cells and functions in iPS reprogramming

(Submitter supplied) Polycomb group (PcG) proteins comprise a large group of evolutionary conserved factors with essential roles for embryonic development and adult stem cell function. PcG proteins constitute two main multiprotein polycomb repressive complexes (PRC1 and PRC2) that operate in a hierarchical manner to silence gene expression. Functionally distinct PRC1 complexes are defined by Polycomb group RING finger protein (PCGF) paralogs. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
6 Samples

Download data: CEL

Series

Accession:: GSE56126

ID:: 200056126

Select item 20002928115.

Single Cell based genomewide gene expression analysis of murine bone-marrow derived Very Small Embryonic-Like Stem Cells (VSELs)

(Submitter supplied) Recently, we identified a population of Oct4+Sca-1+Lin-CD45- very small embryonic-like stem-cells (VSELs) in adult tissues. Open chromatin structure of pluripotency genes and genomic imprinting-related epigenetic mechanisms maintain pluripotency and quiescence of VSELs, respectively. However, global transcriptome signature of this rare stem-cell population remains elusive. Here, we demonstrate by genomewide gene-expression analysis with a small number of highly purified murine bone-marrow (BM)-derived VSELs, that Oct4+ VSELs i) express a similar, yet nonidentical, transcriptome as embryonic stem-cells (ESCs), ii) up-regulate cell-cycle checkpoint genes, iii) down-regulate genes involved in protein turnover and mitogenic pathways, and iv) highly express Ezh2, a polycomb group protein. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL

Series

Accession:: GSE29281

ID:: 200029281

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003085216.

Expression data from Bmi1 mutant versus wild-type lung cells

(Submitter supplied) Bmi1 is an important stem cell regulator in multiple tissues, including the lung. We used microarrays to analyze the dysregulation of gene expression in the absence of Bmi1 in the lung, to identify pathways important in Bmi1-dependent lung stem cell regulation

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4816
Platform:: GPL1261
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE30852

ID:: 200030852

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 481617.

Bmi1 deficiency effect on lung cells

Analysis of primary lung cells FACS-isolated from Bmi1 deficient mutants. BMI1, a member of the Polycomb Repressive Complex 1, is required for the self-renewal of adult stem cells. Results provide insight into the mechanisms underlying the BMI1-dependent regulation of lung stem cell self-renewal.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE30852
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4816

ID:: 4816

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20005662918.

KAP1(TRIM28/TIF1beta) represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1(Ring1b/Rnf2) and derepresses pluripotency-associated genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. GSE56626 GSE56628

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
4 Samples

Download data: CEL

Series

Accession:: GSE56629

ID:: 200056629

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005662819.

KAP1(TRIM28/TIF1beta) represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1(Ring1b/Rnf2) and derepresses pluripotency-associated genes (ChIP-seq)

(Submitter supplied) Embryonic stem (ES) cells express pluripotency-associated genes and repress differentiation-inducible genes. The activities of these genes are coordinately reversed during differentiation. The changes in the transcriptome upon conditional KAP1 knockout in ES cells overlapped with the changes during embryoid body formation. KAP1 repressed differentiation-inducible genes and derepressed pluripotency-associated genes in ES cells. more...