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| Status |
Public on Feb 21, 2011 |
| Title |
Expression data from Bmi1-null c-Kit+Sca-1+Lineage marker- (KSL) hematopoietic stem/progenitor cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf 14. Deletion of both Ink4a and Arf in Bmi1-deficient mice substantially restored the defective self-renewal capacity of HSCs and neural stem cells.
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| Overall design |
Purified KSL cells from BM of wild-type, Bmi1-/-, Ink4a-/-Arf-/-, and Bmi1-/- Ink4a-/-Arf-/- mice were subjected to RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Iwama A, Oguro H, Ichikawa H |
| Citation(s) |
20207230, 22351929 |
| |
| Submission date |
Jan 07, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
ATSUSHI IWAMA |
| E-mail(s) |
aiwama@faculty.chiba-u.jp
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| Phone |
81-43-226-2187
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| Fax |
81-43-226-2191
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| Organization name |
Graduate School of Medicine, Chiba University
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| Department |
Department of Cellular and Molecular Medicine
|
| Street address |
1-8-1 Inohana, Chuo-ku
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| City |
Chiba |
| ZIP/Postal code |
260-8670 |
| Country |
Japan |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA121821 |
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