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Links from GEO DataSets

Items: 12

1.

E. coli imp fabI(G93V) Mutant Cells: Control (E. coli imp fabI(G93V) ) vs. NTG-treated E. coli imp fabI(G93V)

(Submitter supplied) Transcriptional profiling of NTG-treated E. coli imp fabI(G93V) cells compared to control cells (E. coli imp fabI(G93V) ) in the absence or presence of sub-lethal concentration of triclosan.
Organism:
Escherichia coli
Type:
Expression profiling by array
Platform:
GPL5482
2 Samples
Download data: TXT
Series
Accession:
GSE17441
ID:
200017441
2.

S_aureus_&_triclosan

(Submitter supplied) A triclosan-ciprofloxacin cross-resistant mutant strain of Staphylococcus aureus displays an alteration in the expression of several cell membrane structural and functional genes. Triclosan is an antimicrobial agent found in many consumer products. Several studies have demonstrated that triclosan inhibits the bacterial fatty acid biosynthetic enzyme, enoyl-ACP reductase (FabI). Studies have also demonstrated that decreased susceptibility to triclosan correlates with ciprofloxacin resistance in several bacteria. more...
Organism:
Staphylococcus aureus
Type:
Expression profiling by array
Dataset:
GDS3136
Platform:
GPL1339
12 Samples
Download data: CEL
Series
Accession:
GSE5799
ID:
200005799
3.
Full record GDS3136

Triclosan-ciprofloxacin cross-resistant Staphylococcus aureus mutant response to triclosan

Analysis of Staphylococcus aureus JJ5 mutant strain treated with triclosan. JJ5 is a triclosan-ciprofloxacin cross-resistant strain. Triclosan resistance correlates with ciprofloxacin resistance in several bacteria. Results provide insight into the molecular basis of triclosan resistance in JJ5.
Organism:
Staphylococcus aureus
Type:
Expression profiling by array, count, 2 agent, 2 strain sets
Platform:
GPL1339
Series:
GSE5799
12 Samples
Download data: CEL
DataSet
Accession:
GDS3136
ID:
3136
4.

Gene expression of triclosan susceptible and tolerant E. coli O157:H19 in response to triclosan exposure

(Submitter supplied) Triclosan is a biocidal active agent commonly found in domestic cleaning products, hand sanitizers, cosmetics and personal care products. It is used to control microbial contamination and has a broad-spectrum of activity against many Gram-positive and Gram-negative bacteria. The development of triclosan tolerance with potential cross resistance to clinically relevant antibiotics in zoonotic pathogens is of concern given the widespread use of this active agent in clinical, food processing and domestic environments. more...
Organism:
Escherichia coli; Escherichia coli O157
Type:
Expression profiling by array
Platform:
GPL3154
12 Samples
Download data: CEL
Series
Accession:
GSE39343
ID:
200039343
5.

Microarray Analysis of Toxicogenomic Effects of Triclosan on Staphylococcus aureus

(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to triclosan, which involved initial growth inhibition and metabolism. Keywords: Transcriptome study; antimicrobial response; time course
Organism:
Staphylococcus aureus
Type:
Expression profiling by array
Dataset:
GDS2983
Platform:
GPL1339
15 Samples
Download data: CEL
Series
Accession:
GSE8861
ID:
200008861
6.
Full record GDS2983

Triclosan effect on Staphylococcus aureus: time course

Analysis of Staphylococcus aureus cultures treated for 10 or 60 minutes with 0.05 uM triclosan. At this concentration, the antimicrobial agent caused growth inhibition for about 10 min. Results provide insight into the initial molecular response of Staphylococcus aureus to triclosan.
Organism:
Staphylococcus aureus
Type:
Expression profiling by array, count, 2 agent, 3 time sets
Platform:
GPL1339
Series:
GSE8861
15 Samples
Download data: CEL
DataSet
Accession:
GDS2983
ID:
2983
7.

High succinic acid tolerance E.coli (DST160)

(Submitter supplied) To understand cell responses against high succinate stress, a continuous culture was performed for 9 months using a wild Escherichia coli under gradually increasing succinate stress. The final adapted strain against high succinate stress, named DST160, was able to grow with no lag phase in medium containing 1.35 M of succinate stress while wild W3110 showed more than 38 h lag phase. The maximum growth rate and growth yield of DST160 under the stress condition were 0.20 h-1 and 0.192 g-cell/g-glucose, which were 53.8 % and 12.3 % higher than those of W3110 (0.13 h-1 and 0.171 g-cell/g-glucose, respectively).
Organism:
Escherichia coli; Escherichia coli str. K-12 substr. W3110
Type:
Expression profiling by array
Platform:
GPL5482
2 Samples
Download data: GPR
Series
Accession:
GSE17991
ID:
200017991
8.

Multi-omics approach to study global changes in a triclosan mutant strain of Acinetobacter baumannii ATCC 17978.

(Submitter supplied) Acinetobacter baumannii AB042, a triclosan-resistant mutant, was examined for modulated gene expression using whole genome sequencing, transcriptomics, and proteomics in order to understand the mechanism of triclosan-resistance as well as its impact on A. Baumannii.
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22492
4 Samples
Download data: DIFF, TXT, XLSX
Series
Accession:
GSE87398
ID:
200087398
9.

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and mutant E. coli K-12 MG1655 Transcriptomes

(Submitter supplied) The goals of this study are to use Next-generation sequencing (NGS) to detect bacterial mRNA profiles of wild-type E. coli K-12 MG1655 and triclosan induced E. coli mutants in response to 0.2 mg/L triclosan for 8 h, in triplicate, using Illumina HiSeq 2500.The NGS QC toolkit (version 2.3.3) was used to treat the raw sequence reads to trim the 3’-end residual adaptors and primers, and the ambiguous characters in the reads were removed. more...
Organism:
Escherichia coli str. K-12 substr. MG1655
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18956
12 Samples
Download data: TXT
Series
Accession:
GSE107048
ID:
200107048
10.

The transcriptomic response of E. coli to triclosan exposure

(Submitter supplied) The gene expression profile of E. coli K-12 MG1655 grown in minimal medium treated with 0.12 mg/L of the biocide triclosan has been analysed using whole genome oligonucleotide microarrays. "Control" RNA was isolated from three independently grown 50ml MOPS minimal media cultures of E. coli K-12 MG1655. “Test” RNA was isolated from three independently grown 50ml MOPS minimal cultures of E. coli K-12 MG1655, to which was added 0.12 mg/L of triclosan after reaching mid-logarithmic growth phase (OD600 ~ 0.7 +/- 0.02). more...
Organism:
Escherichia coli
Type:
Expression profiling by array
Platform:
GPL3051
3 Samples
Download data: GPR
Series
Accession:
GSE15059
ID:
200015059
11.

Toxicogenomic response of Rhodospirillum rubrum S1H to the model micropollutant triclosan

(Submitter supplied) Aiming at the development of a micropollutant biosensor in the frame of the Micro-Ecological Life Support System Alternative (MELiSSA), a pilot study was initiated to identify triclosan (TCS)-responsive biomarker genes in the MELiSSA carbon-mineralizing microorganism, Rhodospirillum rubrum S1H. TCS is a biocide, commonly found in human excrements and is considered an emerging pollutant in wastewater and the environment. more...
Organism:
Rhodospirillum rubrum ATCC 11170; Rhodospirillum rubrum
Type:
Expression profiling by array
Platform:
GPL7256
2 Samples
Download data: GPR
Series
Accession:
GSE16189
ID:
200016189
12.

Rhodospirillum rubrum S1H Space Flight Experiments

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rhodospirillum rubrum; Rhodospirillum rubrum ATCC 11170
Type:
Expression profiling by array
Platform:
GPL7256
6 Samples
Download data: GPR
Series
Accession:
GSE14265
ID:
200014265
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