|
| Status |
Public on Aug 25, 2007 |
| Title |
Microarray Analysis of Toxicogenomic Effects of Triclosan on Staphylococcus aureus |
| Organism |
Staphylococcus aureus |
| Experiment type |
Expression profiling by array
|
| Summary |
In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to triclosan, which involved initial growth inhibition and metabolism.
Keywords: Transcriptome study; antimicrobial response; time course
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| |
|
| Overall design |
We conducted five independent microarray experiments (biological replicates) in the absence (control) and the presence (experimental) of triclosan. We calculated fold change as the ratio between the signal averages of five untreated (control) and five triclosan-treated (experimental) cultures for 0, 10 and 60 min exposures.
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| |
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| Contributor(s) |
Jang H, Toghrol F, Bentley WE |
| Citation(s) |
18210102 |
| |
| Submission date |
Aug 23, 2007 |
| Last update date |
Oct 18, 2012 |
| Contact name |
Hyeung-Jin Jang |
| E-mail(s) |
hyeungjin@gmail.com
|
| Phone |
410-305-2937
|
| Fax |
410-305-3091
|
| Organization name |
USEPA
|
| Department |
OPP/BEAD
|
| Lab |
MARL
|
| Street address |
701 Mapes Road
|
| City |
ft. meade |
| State/province |
MD |
| ZIP/Postal code |
20755 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1339 |
[S_aureus] Affymetrix S. aureus Genome Array |
|
| Samples (15)
|
| GSM224601 |
Staphylococcus aureus_no treatment_0min_replicate1 |
| GSM224602 |
Staphylococcus aureus_no treatment_0min_replicate2 |
| GSM224603 |
Staphylococcus aureus_no treatment_0min_replicate3 |
| GSM224604 |
Staphylococcus aureus_no treatment_0min_replicate4 |
| GSM224605 |
Staphylococcus aureus_no treatment_0min_replicate5 |
| GSM224606 |
Staphylococcus aureus_Triclosan_10min_replicate1 |
| GSM224607 |
Staphylococcus aureus_Triclosan_10min_replicate2 |
| GSM224608 |
Staphylococcus aureus_Triclosan_10min_replicate3 |
| GSM224609 |
Staphylococcus aureus_Triclosan_10min_replicate4 |
| GSM224610 |
Staphylococcus aureus_Triclosan_10min_replicate5 |
| GSM224611 |
Staphylococcus aureus_Triclosan_60min_replicate1 |
| GSM224612 |
Staphylococcus aureus_Triclosan_60min_replicate2 |
| GSM224613 |
Staphylococcus aureus_Triclosan_60min_replicate3 |
| GSM224614 |
Staphylococcus aureus_Triclosan_60min_replicate4 |
| GSM224615 |
Staphylococcus aureus_Triclosan_60min_replicate5 |
|
| Relations |
| BioProject |
PRJNA102221 |
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