GEO DataSets

(Submitter supplied) The present study investigated arsenic’s effects on mummichogs (Fundulus heteroclitus), while also examining what role that gender or age of exposure might play. Adult male and female mummichogs were exposed to 172ppb, 575ppb, or 1,720ppb arsenic as sodium arsenite for 10 days immediately prior to spawning. No differences were noted in the number or viability of eggs between the groups, but there was a significant increase in deformities in the 1,720ppb arsenic exposure group. more...

Organism:

Fundulus heteroclitus; Pseudopleuronectes americanus

Type:

Expression profiling by array

Platform:

GPL2535

20 Samples

Download data: XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Fundulus heteroclitus; Pseudopleuronectes americanus

Type:

Expression profiling by array

Platform:

GPL2535

80 Samples

Download data: XLS

(Submitter supplied) The present study investigated arsenic’s effects on mummichogs (Fundulus heteroclitus), while also examining what role that gender or age of exposure might play. Adult male and female mummichogs were exposed to 172ppb, 575ppb, or 1,720ppb arsenic as sodium arsenite for 10 days immediately prior to spawning. No differences were noted in the number or viability of eggs between the groups, but there was a significant increase in deformities in the 1,720ppb arsenic exposure group. more...

Organism:

Fundulus heteroclitus; Pseudopleuronectes americanus

Type:

Expression profiling by array

Platform:

GPL2535

30 Samples

Download data: XLS

(Submitter supplied) The present study investigated arsenic’s effects on mummichogs (Fundulus heteroclitus), while also examining what role that gender or age of exposure might play. Adult male and female mummichogs were exposed to 172ppb, 575ppb, or 1,720ppb arsenic as sodium arsenite for 10 days immediately prior to spawning. No differences were noted in the number or viability of eggs between the groups, but there was a significant increase in deformities in the 1,720ppb arsenic exposure group. more...

Organism:

Pseudopleuronectes americanus; Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL2535

30 Samples

Download data: XLS

(Submitter supplied) The Atlantic killifish (Fundulus heteroclitus), native to estuarine areas of the Atlantic coast of the United States, has become a valuable ecotoxicological model due to its ability to acclimate to rapid environmental changes and adapt to polluted habitats. Killifish respond to rapid increases in salinity with an immediate change in gene expression, as well as long-term remodeling of the gills. Arsenic, a major environmental toxicant, was previously shown to inhibit the ability of killifish gill to respond to a rapid increase in salinity. more...

Organism:

Fundulus heteroclitus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL25194

24 Samples

Download data: FA, TXT

(Submitter supplied) The present study used microarray expression profiling to determine the effects of embryonic arsenic exposure. Fertilized killifish (Fundulus heteroclitus) eggs were exposed to 0, 5, 15, or 25ppm arsenic as sodium arsenite. To examine differentially expressed genes, the microarrays were probed using RNA obtained from the control and 25ppm-exposed killifish just after hatching. No differences were noted in survival or hatching success between any of the groups. more...

Organism:

Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL13723

20 Samples

Download data: TXT

(Submitter supplied) Arsenic contamination of drinking water occurs globally and is associated with numerous diseases including skin, lung, and bladder cancers, and cardiovascular disease. The mechanisms behind arsenic's effects remain unclear, but recent research indicates that aresnic acts along sex-specific lines and may be an endocrine disruptor. The objective of this study was to evaluate the nature of gene expression chagnes among males and females exposed to arsenic contaminated water in Bangladesh at high and low dose exposures.The median wAs concentration for the low exposure group was 103 µg/L for males and 117 µg/L for females (range 50–200 µg/L). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16522

29 Samples

Download data: CEL

(Submitter supplied) Cr(III) is the dominant toxicant at some Superfund sites within the United States and therefore we are interested in its effects. Cr(III)’s mechanisms are not well studied or understood because of its low bioavailability. We have attempted to characterize the effects of Cr(III) on gene expression in the liver of adult male Fundulus heteroclitus. The NOEC and LOEC were determined at 32 and 64mg/L, respectively, by measuring growth after exposing juveniles for 30 days. more...

Organism:

Pseudopleuronectes americanus; Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL2535

8 Samples

Download data

(Submitter supplied) In the present study, we employed the RNA sequencing platform to examine the molecular response of zebrafish liver to arsenic exposure and carry out detailed transcriptomic analyses for further understanding of molecular toxicity. We found that several important biological processes were perturbed by arsenic exposure, including oxidation reduction, translation, iron ion transport, cell redox and homeostasis, as well as related pathways in metabolism and diseases. more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16034

2 Samples

Download data: TXT

(Submitter supplied) http://www.mdyn.com/aptrix/upp01077.nsf/Content/codelink_bioarray_system

Organism:

Mus musculus

1 Series

22 Samples

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(Submitter supplied) The goal was to determine differences in gene expression of 384 metabolic genes during late organogenesis among embryos of parents from a clean site (Magotha Bay, VA) and polluted site (Elizabeth RIver, VA). Hybrid gene expression was examined to explore parental effect. Embryo morphology and heart rate during late organogenesis and pre-hatching was assessed in order to determine phenotypic differences between embryo groups.

Organism:

Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL26931

40 Samples

Download data: TXT

(Submitter supplied) Exposure to high levels of arsenic in drinking water is associated with several types of cancers including lung, bladder and skin, as well as vascular disease and diabetes. Drinking water standards are based primarily on epidemiology and extrapolation from higher dose experiments, rather than measurements of phenotypic changes associated with chronic exposure to levels of arsenic similar to the current standard of 10ppb, and little is known about the difference between arsenic in food as opposed to arsenic in water. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3801

Platform:

GPL1261

55 Samples

Download data: CEL, CHP

Analysis of lungs of C57BL/6 males, on defined diets, chronically exposed to environmentally relevant concentrations of arsenic (As) in food or drinking water. Acute exposure to As through intraperitoneal injection also examined. Results provide insight into the basis of As toxicity from ingestion.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 5 agent, 4 dose, 2 growth protocol, 4 protocol sets

Platform:

GPL1261

Series:

GSE11056

55 Samples

Download data: CEL, CHP

(Submitter supplied) Although alternative Flame Retardant (FR) chemicals are expected to be safer than the legacy FRs they replace, their risks to human health and the environment are often poorly characterized. This study used a small volume, fish embryo system to reveal potential mechanisms of action and diagnostic exposure patterns for TBPH (bis (2-ethylhexyl)-tetrabromophthalate), a component of several widely-used commercial products. more...

Organism:

Fundulus heteroclitus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25254

48 Samples

Download data: TXT