GEO DataSets

(Submitter supplied) In our investigations of the molecular pathways of prostate tumorigenesis in Nkx3.1; Pten mutant mice using gene expression profiling, we now find that the AP-1 transcription factors, c-Jun and c-Fos, are significantly up-regulated during cancer progression. Forced expression of c-Fos and c-Jun in prostate cancer cells results in increased tumorigenicity, activation of Erk MAP kinase, and enhanced survival in the absence of androgens, which are hallmarks of disease progression. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

26 Samples

Download data: CEL

(Submitter supplied) Background: Prostate cancer remains one of the most diagnosed malignancies among men worldwide and is responsible for significant morbidity and mortality. Despite advances in diagnostics and therapeutics, effective management and understanding of its molecular biology continue to pose challenges. The disease develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

19 Samples

Download data: TXT

(Submitter supplied) To identify MED1 target genes involved in prostate tumorigenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4846

Platform:

GPL571

4 Samples

Download data: CEL

Analysis of LNCaP prostate cancer cells overexpressing the Mediator of RNA polymerase II transcription factor 1 (MED1). MED1 is a coactivator of the androgen receptor and other signal-activated transcription factors. Results provide insight into the role of MED1 overexpression in prostate cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL571

Series:

GSE41150

4 Samples

Download data: CEL

(Submitter supplied) Analysis of the transcriptome of mouse models of prostate cancer. NP (Nkx3.1CreERT2/+; Ptenfloxed/floxed) mice develop non-metastatic tumors while NPK (Nkx3.1CreERT2/+; Ptenfloxed/floxed; KrasG12D/+) mice develop metastatic tumors The NPK mice are also analyzed at early and late stages of tumorigenesis (1 vs. 3 months after induction)

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

21 Samples

Download data: TXT

(Submitter supplied) Key histological and growth progression characteristics of human prostate cancer are phenocopied in mouse models that have been subjected to androgen level depletion and engineered for hemizygosity of candidate prostate cancer tumor suppressor genes Nkx3.1 and Pten. To characterize their relative transcriptomes and identify a genomic basis for their relevance to human prostate cancers, we compared mouse prostate tumors expression profiles to those from a panel of human prostate cancer isolates and to normal and benign prostates. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

26 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL9052 GPL11532

14 Samples

Download data: CEL, TXT

(Submitter supplied) Triple negative breast cancer (TNBC) is an aggressive clinical phenotype, and accounts for 15% to 20% of all breast cancers. The molecular determinants of malignant cell behaviors in TNBC remain largely unknown. We find that the AP-1 transcription factor component, Fra-1, is overexpressed in basal-like breast tumors, and its expression level has high prognostic significance. Depletion of Fra-1 or its heterodimeric partner c-Jun inhibits the proliferative and invasive phenotypes in TNBC cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

10 Samples

Download data: CEL

(Submitter supplied) Triple negative breast cancer (TNBC) is an aggressive clinical phenotype, and accounts for 15% to 20% of all breast cancers. The molecular determinants of malignant cell behaviors in TNBC remain largely unknown. We find that the AP-1 transcription factor component, Fra-1, is overexpressed in basal-like breast tumors, and its expression level has high prognostic significance. Depletion of Fra-1 or its heterodimeric partner c-Jun inhibits the proliferative and invasive phenotypes in TNBC cells. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL9052

4 Samples

Download data: BED, TXT

(Submitter supplied) PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of human disease. To identify additional pathway alterations that cooperate with PTEN loss in prostate cancer progression, we surveyed human prostate cancer tissue microarrays and found that the RAS/MAPK pathway is significantly elevated both in primary and metastatic lesions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4125

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of prostate tumors from mutants with prostate-specific Pten loss and K-ras activation. In murine models, PTEN deletion alone fails to mimic end stage of human prostate cancer (PC). Results provide insight into cooperation between PTEN loss and RAS activation to promote EMT and metastasis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE34839

6 Samples

Download data: CEL

(Submitter supplied) We profiled the transcriptome in two high-grade glioma (HGG) mouse models driven by mutated receptor tyrosine kinase (RTK) oncogenes, platelet-derived growth factor receptor alpha (PDGFRA), neurotrophic receptor tyrosine kinase 1 (NTRK1). In addition, transcriptome for normal mouse cortex was also profiled. The transcriptome was used to define transcription factor activity by integrating with whole proteome and phosphoproteome datasets.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

18 Samples

Download data: TXT