GEO DataSets

(Submitter supplied) hearts from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords = rat Keywords = heart Keywords = cytokine Keywords = inflammation Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL153

6 Samples

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(Submitter supplied) heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL153 GPL154

12 Samples

Download data

(Submitter supplied) heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords = rat Keywords = cardiac Keywords = cytokine Keywords = inflammation Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL154

6 Samples

Download data

(Submitter supplied) Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. Expression profiling revealed three patterns of gene expression: (1) increased expression above control levels within one hour of cardioplegic arrest, with further amplification during early reperfusion; (2) increased expression limited to the reperfusion phase; and (3) reduced expression during reperfusion. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

12 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Keywords: rat heart ventricles, LAD - left anterior descending coronary artery, IR - ischemia-reperfusion

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1959

Platform:

GPL341

12 Samples

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Analysis of ischemic heart ventricles 2 or 7 days after reperfusion. Ischemia induced by occlusion of the left anterior descending coronary artery. Results provide insight into the molecular mechanisms involved in the early and late inflammatory phases of acute myocardial infarction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 time sets

Platform:

GPL341

Series:

GSE4105

12 Samples

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(Submitter supplied) Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by using local adenovirus-mediated gene transfer of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38α in rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2487

Platform:

GPL1355

10 Samples

Download data: CEL, EXP

Analysis of left heart ventricles of transgenics overexpressing the mitogen-activated protein kinase (MAPK) p38 in their hearts. p38 is involved in the pathophysiology of inflammatory diseases. Results provide insight into the role of p38 in the heart.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1355

Series:

GSE3866

10 Samples

Download data: CEL, EXP

(Submitter supplied) We have studied the genes activated in human liver transplantation to identify potential target genes for the prevention or treatment of related injuries. In a first protocol, in order to evaluate the effect of Ischemia-Reperfusion Injury (IRI) on gene expression profile, we compared gene expression levels in transplanted-reperfused livers versus basal values in donor livers, identifying 795 genes significantly modified in human liver after transplantation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

15 Samples

Download data: CEL

(Submitter supplied) Although major differences in the response of tissues were documented in the literature, the molecular mechanisms underlying tissue radiosensitivity are still fragmentary and need to be study more thoroughly. To this end, a genome wide analysis strategy was used to investigate changes in gene expression in the liver following exposition to ionizing radiation. This follows the tissue survey that was previously initiated with other organs and tends to obtain a comprehensive picture of the molecular events underlying tissue radio sensitivity. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL4377 GPL4376

16 Samples

Download data: GPR

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1353

Platform:

GPL96

12 Samples

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Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL96

Series:

GSE3040

12 Samples

Download data

(Submitter supplied) Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Keywords: Genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2636

Platform:

GPL339

6 Samples

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Analysis of retinas from postnatal day 7 mutants lacking retinoschisin (RS1h), an animal model for retinoschisis (RS). RS is a recessive retinal dystrophy accompanied by macular disease often resulting in early-onset vision loss. Results provide insight into the pathogenesis of RS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5581

6 Samples

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(Submitter supplied) Pre-LVAD and explanted ischemic and nonischemic cardiomyopathy and nonfailing hearts all normalized with RMA Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1362

Platform:

GPL96

37 Samples

Download data: CEL

Analysis of myocardial tissues from nonischemic (NICM) and ischemic cardiomyopathy (ICM) patients. NICM and ICM, major forms of dilated cardiomyopathy leading to congestive heart failure, have similar presentations but differ in pathophysiology, prognosis, and response to therapy.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state sets

Platform:

GPL96

Series:

GSE1869

37 Samples

Download data: CEL

(Submitter supplied) Endocardial (EE) and Aortic (AE) endothelial cells were isolated from the same two rats, pooled (EE and AE kept separately) and cultured for 2 passages. Culture conditions and confluence of EE and AE cell cultures were kept as identical as possible. RNA was isolated and the expression profile of both endothelial cell types was compared using the Affymetrix rat genome U34A array. Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS695

Platform:

GPL85

2 Samples

Download data: CEL, EXP, RPT

Gene expression profiles of endocardial (EE) and aortic (AE) endothelial cells. EE and AE genetic diversity in culture reflects in vivo physiological diversity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL85

Series:

GSE1478

2 Samples

Download data: CEL, EXP, RPT