U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 9

1.
Full record GDS1760

Telomerase reverse transcriptase immortalizing effect on fibroblasts and endothelial cells: time-course

Analysis of normal fibroblasts and endothelial cells, at various population doubling levels (PDLs), following human telomerase reverse transcriptase (hTERT) transfection. hTERT mediates cellular immortalization. Results identify cell-type specific transcriptional responses during immortalization.
Organism:
Homo sapiens
Type:
Expression profiling by array, log2 ratio, 2 cell type, 5 time sets
Platform:
GPL1530
Series:
GSE1900
12 Samples
Download data
DataSet
Accession:
GDS1760
ID:
1760
2.

Immortalization of normal human cells

(Submitter supplied) A normal neonatal human diploid fibroblast strain MJ90 was cultured in Dulbecco's modified Eagle's minimal essential medium (DMEM; Sigma-Aldrich Japan) supplemented with 2 mM L-glutamine (Life Technologies) and 10% fetal calf serum (FCS; Life Technologies). A normal human umbilical vein endothelial cell strain HUE142-2 were grown in MCDB151 medium (Sigma-Aldrich Japan) supplemented with 15% fetal bovine serum, 5 µg/ml of heparin (Sigma), and 5 ng/ml of recombinant acidic fibroblast growth factor in a plastic flask (Corning) precoated with bovine fibronectin solution (1 µg/cm2, Wako).The 40 µg of plasmid hTRT/FLAG or hTERTn2 (from Prof. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1760
Platform:
GPL1530
12 Samples
Download data
Series
Accession:
GSE1900
ID:
200001900
3.

Expression profiles of immortal lung fibroblasts

(Submitter supplied) Activation of telomerase often endows cancer cells, but rarely normal somatic cells, with immortality. Especially, fetal lung fibroblasts are known to be hardly immortalized by TERT overexpression. We here established an immortal non-transformed lung fibroblast cell line only by TERT transfection, as well as an immortal transformed cell line by transfection of TERT and SV40 early antigens. Comparing the expression profiles of these cell lines with those of mortal cell strains with elongated lifespan after TERT transfection, 51 genes, including 19 upregulated and 32 downregulated, were explored to be the candidates responsible for regulation of cellular proliferation of lung fibroblasts. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL1928 GPL570 GPL4133
17 Samples
Download data: CEL, TXT
Series
Accession:
GSE9077
ID:
200009077
4.

Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP)

(Submitter supplied) Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) reveals murine targets for preclinical development of human prostate cancer therapy In this study, we have generated an open source TRAMP microarray dataset to identify differentially expressed genes from human prostate cancer that have concordant expression in TRAMP tumors, and thereby represent lead targets for preclinical therapy development. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE10525
ID:
200010525
5.

Expression Profiling of DA, COP, and F1(COPxDA) rat left ventricles

(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these two strains whose performance was intermediate relative to both parental strains. DA and COP rats differ for both intrinsic aerobic running capacity (assessed with a treadmill exercise test to exhaustion) and intrinsic cardiac performance (as assessed by the Langendorff-Neeley working heart model). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS778 GDS779 GDS780
Platforms:
GPL86 GPL87 GPL85
36 Samples
Download data
Series
Accession:
GSE1795
ID:
200001795
6.
Full record GDS780

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34C)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL87
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS780
ID:
780
7.
Full record GDS779

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34B)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL86
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS779
ID:
779
8.
Full record GDS778

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34A)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL85
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS778
ID:
778
9.

Viral integration promotes SV40T-induced immortalization by disturbing the expression of DNA/chromosome- and ECM-associated functional genes

(Submitter supplied) Lentivirus containing simian virus 40 large T antigen (SV40T) is routinely used to induce cell immortalization. However, the roles of viral integration itself in this progress is still controversial. Here, we transformed primary mouse embryonic fibroblasts (MEFs) with SV40T lentivirus and studied the roles of viral integration in the immortalization using RNA-seq and whole genome sequencing (WGS). During the immortalization, differentially expressed genes (DGEs) are enriched in viral infection and several diverse activities. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
18 Samples
Download data: XLSX
Series
Accession:
GSE247743
ID:
200247743
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=4|blobid=MCID_6723649baac99775972c9d95|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center