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Links from GEO DataSets

Items: 5

1.
Full record GDS1675

Werner syndrome protein and poly(ADP-ribose) polymerase-1 null mutants

Analysis of embryonic fibroblast cells lacking Werner syndrome (WS) protein (Wrn), or poly(ADP-ribose) polymerase-1 (PARP-1), or both. Mutations in Wrn or PARP-1 result in genomic instability. Results provide insight into tumor progression, senescence, oxidative stress and aging.
Organism:
Mus musculus
Type:
Expression profiling by array, log ratio, 3 genotype/variation sets
Platform:
GPL891
Series:
GSE3359
6 Samples
Download data
DataSet
Accession:
GDS1675
ID:
1675
2.

Differential expression of genes in cells mutant for Wrn and/or PARP-1 compared to wild type cells

(Submitter supplied) Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. The poly(ADP-ribose) polymerase-1 (PARP-1) enzyme is also involved in DNA repair and is known to affect transcription of several genes. In this study, we examined the expression profile of cells lacking the normal function of either or both enzymes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1675
Platform:
GPL891
6 Samples
Download data
Series
Accession:
GSE3359
ID:
200003359
3.

H2O2 effect on mouse embryonic fibroblasts +/- a deletion in the helicase domain of the Werner Syndrome gene homologue

(Submitter supplied) [original Title] Expression profiling of mouse embryonic fibroblasts with or without a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7042
6 Samples
Download data: TXT
Series
Accession:
GSE19007
ID:
200019007
4.

Gene expression profiling in the liver of 3-month old mice with a mutant Wrn protein treated with vitamin C compared to 3-month old WT mice

(Submitter supplied) Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase domain of the murine WRN homologue that recapitulates most of the WS phenotypes including an abnormal hyaluronic acid excretion, higher reactive oxygen species (ROS) levels, increased genomic instability and cancer incidence resulting in a 10-15% decreased life span expectancy. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
4 Samples
Download data: TXT
Series
Accession:
GSE66642
ID:
200066642
5.

Gene expression profiling in the liver of 3-month old mice with a mutant Wrn protein compared to 3-month old WT mice

(Submitter supplied) Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase domain of the murine WRN homologue that recapitulates most of the WS phenotypes including an abnormal hyaluronic acid excretion, higher reactive oxygen species (ROS) levels, increased genomic instability and cancer incidence resulting in a 10-15% decreased life span expectancy. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
4 Samples
Download data: GPR, TXT
Series
Accession:
GSE66584
ID:
200066584
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