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Links from GEO DataSets

Items: 13

1.
Full record GDS1435

Transcription factor p63 null mutation effect on skin (MG-U74B)

Analysis of skin from transcription factor p63 homozygous null mutants at embryonic age E18.5. Without p63, the epidermis fails to commit to stratification, resulting in aborted skin development. Results identify p63 target genes and provide insight into early events in epidermal morphogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL82
Series:
GSE3108
4 Samples
Download data
DataSet
Accession:
GDS1435
ID:
1435

PubMed Similar studies GEO Profiles Analyze DataSet

2.

Comparison of gene expression profiles of p63 null skin versus wild type skin

(Submitter supplied) In the absence of p63 expression, the epidermis fails to commit to stratification, resulting in aborted skin development. In this study, gene expression profiles of E18.5 p63 null and wt skin, were compared in an effort to identify genes that are directly or indirectly regulated by p63. Keywords: Genetically modified mice
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS1434 GDS1435
Platforms:
GPL81 GPL82
8 Samples
Download data
Series
Accession:
GSE3108
ID:
200003108

PubMed Similar studies Analyze with GEO2R

3.
Full record GDS1434

Transcription factor p63 null mutation effect on skin (MG-U74A)

Analysis of skin from transcription factor p63 homozygous null mutants at embryonic age E18.5. Without p63, the epidermis fails to commit to stratification, resulting in aborted skin development. Results identify p63 target genes and provide insight into early events in epidermal morphogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL81
Series:
GSE3108
4 Samples
Download data
DataSet
Accession:
GDS1434
ID:
1434

PubMed Similar studies GEO Profiles Analyze DataSet

4.

Comparison of gene expression in the epidermis of Tcfap2c mutant and control skin at embryonic day 16.5

(Submitter supplied) The development of the epidermis, a stratified squamous epithelium, is dependent on the regulated differentiation of keratinocytes. Differentiation begins with the initiation of stratification, a process tightly controlled through proper gene expression. AP-2γ is expressed in skin and previous research suggested a pathway where p63 gene induction results in increased expression of AP-2γ which in turn is responsible for induction of K14. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3171
Platform:
GPL1261
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE10175
ID:
200010175

PubMed Full text in PMC Similar studies Analyze with GEO2R

5.
Full record GDS3171

Transcription factor AP-2 gamma mutation effect on the embryonic skin

Analysis of back skin from embryonic day 16.5 animals bearing a mutation in transcription factor AP-2 gamma. The E16.5 AP-2 gamma mutants display abnormal epidermal stratification. Results provide insight into the role of AP-2 gamma in skin development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE10175
6 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS3171
ID:
3171

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

6.

AP-2γ is Required for Maintenance of Multipotent Mammary Stem Cells

(Submitter supplied) Mammary gland ductal morphogenesis depends on the differentiation of mammary stem cells (MaSCs) into basal and luminal lineages. The AP-2γ transcription factor, encoded by Tfap2c, has a central role in mammary gland development but its effect in mammary lineages and specifically MaSCs is largely unknown. Herein, we utilized an inducible, conditional knockout of Tfap2c to elucidate the role of AP-2γ in maintenance and differentiation of MaSCs. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE143159
ID:
200143159

PubMed Full text in PMC Similar studies SRA Run Selector

7.

Gene expression profiling of IR-/-, IGF-1R-/- (dKO) newborn epidermis.

(Submitter supplied) Analysis of newborn mouse epidermis lacking the expression of Insulin receptor (IR) and Insulin like growth factor 1 receptor (IGF-1R). Results show that IR/IGF-1R signalling control epidermal morphogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE47065
ID:
200047065

PubMed Full text in PMC Similar studies Analyze with GEO2R

8.

TRIM37 augments AP-2γ transcriptional activity and cellular localization via K63-linked polyubiquitination to drive breast cancer progression.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
8 Samples
Download data: BED, BW
Series
Accession:
GSE182547
ID:
200182547

PubMed Full text in PMC Similar studies

9.

TRIM37 augments AP-2γ transcriptional activity and cellular localization via K63-linked polyubiquitination to drive breast cancer progression [ChIP-seq]

(Submitter supplied) Using a proteomics approach, we identified the Tripartite Motif Containing 37 (TRIM37) as a novel transcriptional coactivator of AP-2γ. We demonstrate TRIM37 facilitates AP-2γ chromatin binding to regulate the AP-2γ mediated transcriptional program directly. We provide evidence that TRIM37 achieves this by stimulating K63-chain-linked polyubiquitination of AP-2γ, promoting protein localization from the cytoplasm to the nucleus. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
5 Samples
Download data: BED, BW
Series
Accession:
GSE182546
ID:
200182546

PubMed Full text in PMC Similar studies SRA Run Selector

10.

TRIM37 augments AP-2γ transcriptional activity and cellular localization via K63-linked polyubiquitination to drive breast cancer progression [RNA-seq]

(Submitter supplied) Using a proteomics approach, we identified the Tripartite Motif Containing 37 (TRIM37) as a novel transcriptional coactivator of AP-2γ. We demonstrate TRIM37 facilitates AP-2γ chromatin binding to regulate the AP-2γ mediated transcriptional program directly. We provide evidence that TRIM37 achieves this by stimulating K63-chain-linked polyubiquitination of AP-2γ, promoting protein localization from the cytoplasm to the nucleus. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
3 Samples
Download data: TSV
Series
Accession:
GSE182545
ID:
200182545

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

11.

Activation of p63 initiates quality control programs in oocytes

(Submitter supplied) Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations are, therefore,
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
13 Samples
Download data: CSV, SF
Series
Accession:
GSE184704
ID:
200184704

PubMed Full text in PMC Similar studies SRA Run Selector

12.

Distinct modes of cell competition shape mammalian tissue morphogenesis

(Submitter supplied) Cell competition (CC)—the sensing and elimination of less fit “loser” cells by neighbouring “winner” cells—was first described in Drosophila. Although proposed as a selection mechanism to optimize tissue and organ development, its evolutionary generality remains unclear. Here, by employing live-imaging, lineage-tracing, single cell transcriptomics and genetics, we unearth two intriguing CC mechanisms that sequentially shape and maintain stratified tissue architecture during mouse skin development. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
975 Samples
Download data: CSV, TXT
Series
Accession:
GSE128241
ID:
200128241

PubMed Full text in PMC Similar studies SRA Run Selector

13.

A spatio-temporal characterization of the transcriptional landscape of epidermal development

(Submitter supplied) The mouse epidermis develops from a single layer of cells at e9.5 to a fully formed organ at birth capable of performing essential functions. The regularity of the epidermal differentiation program creates an excellent system to explore the mechanisms required for this transition from transit amplifying/ stem cell to differentiated cell and to identify key regulators in this biological process. Here we use FACS sorting of transgenic mice to separate the developing epidermis into its differentiating populations. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
16 Samples
Download data: DIFF
Series
Accession:
GSE75931
ID:
200075931

PubMed Full text in PMC Similar studies SRA Run Selector

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