GEO DataSets

Analysis of peripheral blood and bone marrow of chronic myelogenous leukemia (CML) patients prior to imatinib (Gleevec) treatment. Imatinib induces complete cytogenetic response (CCR) in most CML patients. This study attempts to determine transcriptional signature of imatinib non-responders.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 2 other sets

Platform:

GPL8300

Series:

GSE2535

28 Samples

Download data: CEL

Analysis of cultured epidermal keratinocytes treated with the synthetic glucocorticoid (GC) dexamethasone for up to 72 hours. GCs are used as therapeutic agents for skin conditions. Results provide insight into the molecular response of the epidermis to GCs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 5 time sets

Platform:

GPL8300

Series:

GSE26487

20 Samples

Download data: CEL

Analysis of prolactinomas and normal pituitary tissues. Prolactinoma is a benign pituitary tumor that produces excessive prolactin resulting in hyperprolactinemia. Results provide insight into molecular mechanisms underlying the pathogenesis of this pituitary condition.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL8300

Series:

GSE36314

7 Samples

Download data: CEL

Analysis of bronchial biopsies from allergic asthma (AA) subjects following inhaled corticosteroids (ICS) therapy. ICS represent potent anti-inflammatory controller medications for the treatment of asthma. Results provide insight into molecular mechanisms underlying the pathophysiology of AA.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 2 disease state, 2 specimen sets

Platform:

GPL8300

Series:

GSE15823

12 Samples

Download data: CEL

Analysis of primary macrophages from three donors (D1, D2, D3) up to 6 hrs after in vitro exposure to purified Zaire ebolavirus (ZEBOV) virions. ZEBOV is the etiological agent of Ebola Hemorrhagic Fever (EHF). Results provide insight into the initial response of macrophages exposed to Ebola virions.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 individual, 2 infection, 2 time sets

Platform:

GPL8300

Series:

GSE31747

12 Samples

Download data: CEL, CHP

Analysis of myotube cell lines established from type 2 diabetes (T2D) subjects. Insulin resistance and reduced mitochondrial biogenesis coexist early in T2D pathogenesis independent of hyperglycemia and obesity. Results provide insight into the effect of T2D on developing skeletal muscle cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL8300

Series:

GSE12643

20 Samples

Download data: CEL

Analysis of endometrial epithelial cells from stage I or II endometrioid carcinomas after treatment with oestrogen or tamoxifen (TMX). Results provide insight into the molecular basis of the association of TMX treatment of breast cancer with an increased incidence of endometrial cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 2 disease state sets

Platform:

GPL8300

Series:

GSE3013

7 Samples

Download data: CEL, EXP

Expression profiling of peripheral blood mononuclear cells (PBMC) from patients with advanced renal cancer following treatment with the rapamycin analog CCI-779. Gene expression examined 8 and 16 weeks after treatment. Results identify potential gene markers of CCI-779 exposure.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 time sets

Platform:

GPL8300

Series:

GSE1982

79 Samples

Download data

Analysis of cultured abdominal subcutaneous mature adipocytes from 5 male and 5 female non-diabetic obese Pima Indians. The prevalence of obesity in Pima Indians is among the highest of any population. Results provide insight into the role of adipocytes in obesity and obesity-related inflammation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 gender sets

Platform:

GPL8300

Series:

GSE2508

20 Samples

Download data

Analysis of cultured macrophages for up to 7 days after HIV-1 infection. Macrophages are targets of HIV-1 infection and constitute a viral reservoir that facilitates the spread of HIV-1 to other cells. Results provide insight into the signaling networks affected by HIV-1 infection in macrophages.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 infection, 3 time sets

Platform:

GPL8300

Series:

GSE13395

16 Samples

Download data: CEL

Analysis of colorectal adenocarcinomas resected from patients treated with celecoxib for 7 days. Celecoxib is a cycooxygenase-2 inibitor that exhibits anti-cancer activity. Results provide insight into the mechanism of action of celecoxib in vivo.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL8300

Series:

GSE11237

23 Samples

Download data: CEL

Analysis of postmortem prefrontal cortices from subjects with bipolar disorder, depression, and schizophrenia. Results provide insight into the molecular pathophysiology of these mental disorders.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state sets

Platform:

GPL8300

Series:

GSE12654

50 Samples

Download data: CEL

Analysis of cultured sebaceous gland cells (SEB-1 sebocytes) treated with 13-cis retinoic acid (13-cis RA, isotretinoin), a potent acne treatment agent that reduces the size and secretion of sebaceous glands. Results provide insight into the molecular basis for 13-cis RA's acne-clearing effect.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL8300

Series:

GSE10432

6 Samples

Download data: CEL

Analysis of synovial fluid macrophages from 5 patients with rheumatoid arthritis (RA). The chronic inflammation and progressive joint destruction observed in RA are mediated in part by macrophages. Results provide insight into the molecular mechanisms underlying RA pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL8300

Series:

GSE10500

8 Samples

Download data: CEL, CHP

Analysis of monocytes treated with an NF-kappaB or a phosphatidylinositol 3-kinase (PI3K) inhibitor and then infected with the human cytomegalovirus (HCMV). Results provide insight into the role of NF-kappaB and PI3K in the activation of monocytes to a proinflammatory state after an HCMV infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL8300

Series:

GSE9601

12 Samples

Download data: CEL, CHP

Analysis of HEp2 epithelial cells subjected to heat stress at temperatures of 37 to 40 degrees C. Results provide insight into the regulatory pathways that control the response to heat stress.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 temperature sets

Platform:

GPL8300

Series:

GSE7458

13 Samples

Download data: CEL, CHP

Analysis of dendritic cells (DCs) at various time points up to 36 hours following treatment with TGF-beta1. DCs derived from CD34+ hematopoietic progenitor cells induced to differentiate in vitro. Results provide insight into the role of TGF-beta1 in DC development.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 cell type, 5 time sets

Platform:

GPL8300

Series:

GSE5178

8 Samples

Download data: CEL

Comparison of synovial fibroblasts from patients with rheumatoid arthritis (RA) to those with osteoarthritis (OA). RA is characterized by chronic inflammation and destruction of multiple joints. OA is a degenerative disease resulting from the breakdown of cartilage.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 other sets

Platform:

GPL8300

Series:

GSE7669

12 Samples

Download data: CEL, CHP

Analysis of microvascular endothelial cells (ECs) treated with the myeloid-related protein 8 (MRP8) and 14 (MRP14), proteins that form heterodimers secreted by phagocytes at inflammatory sites. Results provide insight into the role of MRP8 and MRP14 in EC cell death during inflammation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL8300

Series:

GSE5474

8 Samples

Download data

Comparison of low and high grade astrocytoma brain tumors. Results provide insight into the molecular differences between the two types of tumors.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state, 2 other sets

Platform:

GPL8300

Series:

GSE3185

16 Samples

Download data: CEL