GEO DataSet Links for BioProject (Select 137055) - GEO DataSets

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Items: 3

Select item 2000279141.

Expression data from LNCap cell line treated with COP1 (RFWD2), ETV1, and JUN siRNAs

(Submitter supplied) The proto-oncogenes ETV1, ETV4, and ETV5 encode members of the E26 transformation-specific (ETS) transcription factor family, which includes the most frequently rearranged and overexpressed genes in prostate cancer. Despite being critical regulators of development, little is known about their post-translational regulation. Here we identify the ubiquitin ligase COnstitutive Photomorphogenic-1 (COP1, also called RFWD2) as a tumor suppressor that negatively regulates ETV1, ETV4, and ETV5. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS4158 GDS4159
Platform:: GPL570
31 Samples

Download data: CEL

Series

Accession:: GSE27914

ID:: 200027914

Select item 41592.

LNCap prostate cancer cell line response to loss of COnstitutive Photomorphogenic-1, ETV1 and c-JUN

Analysis of LNCap prostate cancer cells following siRNA-mediated knockdown of COP1, ETV1, and c-JUN. Ubiquitin ligase COP1 (RFWD2) negatively regulates the abundance of ETV1 and c-JUN, both of which have been linked to PC. Results provide insight into the role of COP1 as a tumor suppressor in PC.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:: GPL570
Series:: GSE27914
15 Samples

Download data: CEL

DataSet

Accession:: GDS4159

ID:: 4159

Select item 41583.

LNCap prostate cancer cell line response to loss of COnstitutive Photomorphogenic-1 and ETV1

Analysis of LNCap prostate cancer (PC) cells following siRNA-mediated knockdown of COP1 and ETV1. Ubiquitin ligase COP1 (RFWD2) negatively regulates proto-oncogene ETV1 which has been linked to PC. Results provide insight into the role of COP1 as a tumor suppressor in PC.