LNCap prostate cancer cell line response to loss of COnstitutive Photomorphogenic-1, ETV1 and c-JUN
Summary:
Analysis of LNCap prostate cancer cells following siRNA-mediated knockdown of COP1, ETV1, and c-JUN. Ubiquitin ligase COP1 (RFWD2) negatively regulates the abundance of ETV1 and c-JUN, both of which have been linked to PC. Results provide insight into the role of COP1 as a tumor suppressor in PC.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Vitari AC, Leong KG, Newton K, Yee C et al. COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature 2011 May 15;474(7351):403-6. PMID: 21572435
