GEO DataSet Links for BioProject (Select 108357) - GEO DataSets

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Items: 2

Select item 2000101621.

Transcriptional Adaptation to Clcn5 Knockout in Proximal Tubules of the Mouse Kidney

(Submitter supplied) Dent disease has multiple defects attributed to proximal tubule malfunction including low molecular weight proteinuria, aminoaciduria, phosphaturia and glycosuria. In order to understand the changes in kidney function of the Clc5 transporter gene knockout mouse model of Dent disease, we examined gene expression profiles from proximal tubules of mouse kidneys. Overall 720 genes are expressed differentially in the proximal tubules of the Dent Clcn5 knockout mouse model compared to those of control wild type mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3397
Platform:: GPL1261
6 Samples

Download data: CEL, CHP, EXP

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Accession:: GSE10162

ID:: 200010162

Select item 33972.

Dent disease model: renal proximal tubules

Analysis of renal proximal tubules dissected from CLCN5 deficient animals, a model for Dent disease. Clcn5 is a chloride/protein exchanger expressed in renal tubules. Results provide insight into the molecular pathophysiology of Dent disease.