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Defining the mechanisms and properties of post-transcriptional regulatory disordered regions by high-throughput functional profiling

(Submitter supplied) Disordered regions within RNA binding proteins are required to control mRNA decay and protein synthesis. To understand how these disordered regions modulate gene expression, we surveyed regulatory activity across the entire disordered proteome using a high-throughput functional assay. We identified hundreds of regulatory sequences within intrinsically disordered regions and demonstrate how these elements cooperate with core mRNA decay machinery to promote transcript turnover. more...
Organism:
Saccharomyces cerevisiae
Type:
Other
Platform:
GPL21656
78 Samples
Download data: CSV, TXT
Series
Accession:
GSE254492
ID:
200254492

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