GEO DataSets

(Submitter supplied) The gut microbiota plays an important role in host health. Microbiota dysbiosis has been implicated in the global epidemic of Metabolic Syndrome (MetS) and could impair host metabolism by noxious metabolites. It has been well established that the gut microbiota is shaped by host immune factors. However, the effect of T cells on the gut microbiota is yet unknown. Here, we performed a metagenomic whole-genome shotgun sequencing (mWGS) study of the microbiota of TCRb-/- mice, which lack alpha/beta T cells.

Organism:

feces metagenome

Type:

Other

Platform:

GPL33160

14 Samples

Download data: TSV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

feces metagenome; Mus musculus

Type:

Other; Expression profiling by high throughput sequencing

Platforms:

GPL24116 GPL19057 GPL24247

32 Samples

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(Submitter supplied) To examine the microbiota abundance difference, we performed fecal 16s sequencing of wild type, TCRb-/-, TCRb-/- co-housed with WT and TCRb-/- receiving WT T cells.

Organism:

feces metagenome

Type:

Other

Platform:

GPL24116

19 Samples

Download data: RDS

(Submitter supplied) Background: Alcohol misuse, binge drinking pattern, and gender-specific effects in the middle-aged population has been clearly underestimated. In the present study, we focused on understanding gender-specific effects of alcohol exposure on the gut-liver axis and the role of gut microbiota in modulating gender-specific responses to alcohol consumption. Methods: Fifty-two-week-old female and male C57BL/6 mice were fasted for 12 h, and then administered a single oral dose of ethanol (EtOH) (6 g/kg). more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL34367

11 Samples

Download data: CSV

(Submitter supplied) Background: Lung is the largest mucosal area of the human body and directly connected to the external environment, facing microbial exposure and environmental stimuli. Therefore, studying the internal microorganisms of the lung is crucial for a deeper understanding of the relationship between microorganisms and the occurrence and progression of lung cancer. Methods: Tumor and adjacent nontumor tissues were collected from 38 lung adenocarcinoma patients and used nanopore sequencing technology to sequence the 16s full-length sequence of bacteria, and combining bioinformatics methods to identify and quantitatively analyze microorganisms in tissues, as well as to enrich the metabolic pathways of microorganisms. more...

Organism:

metagenomes

Type:

Other

Platform:

GPL34320

74 Samples

Download data: TXT

(Submitter supplied) The study critically evaluate the results of 16S targeted amplicon sequencing performed on the total DNA collected from healthy donors’ blood samples in the light of specific negative controls.

Organism:

Mus musculus; human blood metagenome; Escherichia coli

Type:

Other

Platforms:

GPL16085 GPL34159 GPL16417

15 Samples

Download data: FASTA, TSV, TXT

(Submitter supplied) Folic acid deficiency is common worldwide and is linked to intestinal flora imbalance. The intestinal microbial utilization of folic acid based on model animals faces the challenges of repeatability and individual variability. In this study, we built an in vitro fecal slurry culture model deficient in folic acid. We examined the effects of supplementation with different forms of folic acid (5-methyltetrahydrofolate and non-reduced folic acid) on the modulation of intestinal flora. more...

Organism:

human feces metagenome

Type:

Other

Platform:

GPL31937

96 Samples

Download data: TSV, TXT, XLS

(Submitter supplied) The neurotoxic effects and mechanisms of low-dose and long-term sulfamethoxazole (SMZ) exposure remain unknown. This study exposed zebrafish to environmental SMZ concentrations and observed behavioral outcomes. SMZ exposure increased hyperactivity and altered the transcript levels of 17 genes associated with neurological function. It impaired intestinal function by reducing the number of intestinal goblet cells and lipid content. more...

Organism:

feces metagenome

Type:

Other

Platform:

GPL24920

6 Samples

Download data: TXT, XLSX

(Submitter supplied) The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammatory-linked pathogenic bacteria in patients with gastroesophageal reflux disease, Barrett’s esophagus and esophageal adenocarcinoma (EAC). However, mechanisms by which microbial communities contribute to reflux-driven EAC remain incompletely understood and challenging to target. Herein, we utilized a rat reflux-induced EAC model to investigate targeting the gut microbiome-esophageal metabolome axis with cranberry proanthocyanidins (C-PAC) to inhibit EAC progression. more...

Organism:

rat gut metagenome

Type:

Other

Platform:

GPL24042

25 Samples

Download data: CSV

(Submitter supplied) Esophageal squamous cell carcinoma (ESCC) is characterized as a metabolic disorder characterized by lipid metabolic reprogramming. To investigate the regional characteristics of ESCC patients in Xinjiang Province, China, and lipid metabolism, in this study, we described the characteristics of the serum lipid composition in Kazakh ESCC patients by performing an integrated analysis of the transcriptome and lipidomic data. more...

Organism:

Homo sapiens; solid waste metagenome

Type:

Non-coding RNA profiling by array

Platform:

GPL30375

6 Samples

Download data: TXT

(Submitter supplied) DOCK8 is required for T cell-dependent gut IgA by maintaining plasma cell metabolic fitness

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

60 Samples

Download data: TXT

(Submitter supplied) Systemic sclerosis (SSc) is a complex and still unclear rare disease associated with fibrosis in multiple organs. Microbiota has recently emerged as an important environmental factor in SSc pathogenesis, either at gut, oral and skin level.

Organism:

human skin metagenome; human saliva metagenome; human feces metagenome

Type:

Other

Platforms:

GPL29470 GPL31025 GPL32156

78 Samples

Download data: FASTA, TXT

(Submitter supplied) Dietary restriction has shown benefits in physiological, metabolic, and molecular signatures associated with aging. In mice, periodic dietary restriction, that accompanies cyclical periods of reduced calories, mitigates aging phenotypes, yet the effects of this periodic restriction in higher order, genetically heterogenous mammals, have not been investigated. Reducing caloric intake in middle-aged Rhesus Macaques for four days followed by ad libitum eating for ten days, repeated for six cycles, led to significant changes in body composition, metabolome, and microbiome of the restricted monkeys compared to their ad libitum fed (age and sex matched) controls. more...

Organism:

gut metagenome

Type:

Other

Platform:

GPL33529

140 Samples

Download data: TXT

(Submitter supplied) Mild or transient dietary restriction (DR) improves many aspects of health and aging. Emerging evidence from us and others has demonstrated that DR also optimizes the development and quality of immune responses. However, the factors and mechanisms involved remain to be elucidated. Here, we demonstrate that DR-induced optimization of immunological memory requires co-operation between memory T cells, the intestinal microbiota, and myeloid cells. more...

Organism:

feces metagenome

Type:

Other

Platform:

GPL24116

17 Samples

Download data: TSV

(Submitter supplied) Microbiome dysregulation affects the estrogen metabolism (estrobolome) profile which in turns affects the immunological response. Estrogen hormone is an essential hormone that regulates the sexual activity in females as well as immune response in both sexes. Endometriosis is one of complicated disorder influnce the fertility of females due to escape of endometrial tissue into peritoneal cavity where the immunotoxicity will be undertaken. more...

Organism:

mouse gut metagenome

Type:

Other

Platform:

GPL21051

16 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

feces metagenome; Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL24247 GPL24116

108 Samples

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(Submitter supplied) Gut microbial dysbiosis can play a causal role of in colorectal cancer. Gut microbiota chnages with age and becomes moer pro-inflammatory. We sought to determine whether microbiota from Old donors promotes more tumor formation in recipients than meterial from young donors.

Organism:

feces metagenome

Type:

Other

Platform:

GPL24116

72 Samples

Download data: TXT

(Submitter supplied) We assessed the effects of supplementing milk fat globules (MFG) on the growth and development of the skeleton in rats fed a Western unbalanced diet (UBD). The UBD is high in sugar and fat, low in protein, fiber, and micronutrients, and negatively impacts health. The MFG—a complex structure secreted in milk—has a unique proteome and lipidome, and differs significantly from isolated dietary ingredients. more...

Organism:

rat gut metagenome

Type:

Other

Platform:

GPL33638

30 Samples

Download data: TXT

(Submitter supplied) Abstract. Background: The cause of ulcerative colitis (UC) is not yet fully understood. Previous research has pointed towards a potential role for mutations in NOD2 in promoting the onset and progression of inflammatory bowel disease (IBD) by altering the microbiota of the gut. However, the relationship between toll-like receptor 4 (TLR4) and gut microbiota in IBD is not well understood. To shed light on this, the interaction between TLR4 and gut microbiota was studied using a mouse model of IBD. more...

Organism:

feces metagenome

Type:

Other

Platform:

GPL24116

12 Samples

Download data: XLSX

(Submitter supplied) This study demonstrates the usefulness of the API by generating a baseline gut microbiota profile of a healthy population and estimating reference intervals for the functional abundance of manually selected KEGG pathways. API facilitates microbiome research by providing dynamic and customizable tools for estimating reference intervals for gut microbiota functional abundances. Through the API, researchers can rapidly generate gut microbiota functional profiles of healthy populations to use as a baseline for comparison. more...

Organism:

human feces metagenome

Type:

Other

Platform:

GPL33296

57 Samples

Download data: TSV