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Items: 1 to 20 of 48

1.

RNA Expression Profiling of spinal cord tissues in a Rat Model of Neuropathic Pain

(Submitter supplied) Neuropathic pain (NP), defined as a complex chronic pain state caused by somatosensory nervous system lesions or diseases, is currently the most challenging clinical neurological disorder in the world. The main signs and symptoms of NP include spontaneous pain, abnormal pain and hyperalgesia. It is generally believed that the specific pathological causes of NP include spinal cord or peripheral spinal cord injury, postherpetic neuralgia, trigeminal neuralgia, and tumor invasion. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
6 Samples
Download data: XLS
Series
Accession:
GSE256472
ID:
200256472

2.

In situ tissue profile of rat trigeminal nerve in trigeminal neuralgia using spatial transcriptome sequencing

(Submitter supplied) Investigation on the transcriptome and intercellular communication of different cells of trigeminal nerve in trigeminal neuralgia rat by spatial transcriptome sequencing
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE233838
ID:
200233838

3.

CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

(Submitter supplied) In dorsal root ganglia (DRG), macrophages reside in close proximity to sensory neurons, and their functions have largely been explored in the context of pain, nerve injury and repair. In this study, however, we discovered that the majority of macrophages in DRGs are in direct contact with the vasculature where they constantly monitor the circulation, efficiently phagocytosing proteins and macromolecules from the blood. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
2 Samples
Download data: MTX, RDS, TSV, TXT
Series
Accession:
GSE246168
ID:
200246168

4.

Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model

(Submitter supplied) Beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC) synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, although the underlying regulatory mechanisms remain unknown. Here, we elucidated a novel epigenetic pathway driven by microRNA regulation of beta-endorphin synthesis in ARC neurons to control neuropathic pain. In pain-injured rats miR-203a-3p was the most highly upregulated miRNA in the ARC. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL24688
6 Samples
Download data: TXT
Series
Accession:
GSE216965
ID:
200216965

5.

Cerebrospinal fluid immune cells appear similar across neuropathic and non-neuropathic pain conditions.

(Submitter supplied) Microglia have been implicated in the pathophysiology of neuropathic pain. Here, we sought to investigate whether cerebrospinal fluid (CSF) might be used as a proxy-measure of microglial activation in human participants. For this, we preformed fluorescent-activated cell sorting (FACS) of CSF immune cell populations derived from individuals who experienced pain with neuropathic features. We sorted CD4+, CD8+ T cells and monocytes and analyzed their transcriptome using RNA sequencing. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL18573 GPL24676
19 Samples
Download data: MTX, ROBJ, TSV, XLSX
Series
Accession:
GSE244499
ID:
200244499

6.

Highly synchronized cortical circuit dynamics revealed by a new mouse model of neuropathic pain

(Submitter supplied) The cerebral cortex plays a key role in the multi-dimensional human pain experience. However, the neural mechanisms mediating pain-related cortical activity remain largely unknown, particularly in primary somatosensory cortex (S1). We therefore developed a new animal model of trigeminal neuralgia, a prototypical neuropathic pain, which allowed us to evaluate pain-related cortical dynamics with unprecedented translational relevance. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16417
12 Samples
Download data: CSV
Series
Accession:
GSE162284
ID:
200162284

SRA Run Selector

7.

Transcriptome map of dorsal root ganglion and spinal cord in mice with acute herpetic neuralgia induced by HSV-1

(Submitter supplied) To study the gene expression at the level of dorsal root ganglia and spinal cord in acute herpetic neuralgia mice, we induced acute herpetic neuralgia by subcutaneous injection of HSV-1 virus fluid into the tibia of C57/6J mice. We collected data obtained from RNA-seq of dorsal root ganglia and spinal cord tissue in acute herpetic neuralgia mice (7 days after virus injection) and control mice for gene expression profiling.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23479
12 Samples
Download data: CSV
Series
Accession:
GSE208282
ID:
200208282

8.

RNA sequencing of whole blood cells in patients with trigeminal neuralgia

(Submitter supplied) Trigeminal neuralgia (TN) is a type of neuropathic pain caused by injury to sensory nerves, manifesting as severe paroxysmal pain of the head and face. Trigeminal neuralgia brings a huge burden to patients, without long-term effective treatment. Changes in the expression of pain-related genes in the whole blood samples of patients play an important role in the pathogenesis, diagnosis, and evaluation of treatment effects of trigeminal neuralgia. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
20 Samples
Download data: TXT
Series
Accession:
GSE186505
ID:
200186505

Analyze with GEO2RSRA Run Selector

9.

Identification of key genes potentially related to intervertebral disc degeneration by microarray analysis

(Submitter supplied) Although the pathology of sciatica has been studied extensively, the transcriptional changes in the peripheral blood caused by sciatica have not been characterized.  An Agilent SurePrint G3 human gene expression microarray 8 ╳ 60 K was used to analyse gene expression in whole blood from patients with sciatica compared with healthy volunteers.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21185
59 Samples
Download data: TXT
Series
Accession:
GSE150408
ID:
200150408

Analyze with GEO2R

10.

Transcriptome signatures reveal candidate key genes in the whole blood of patients with lumbar disc prolapse

(Submitter supplied) The present study aimed to investigate differentially expressed genes in whole blood obtained from patients with lumbar disc prolapse and healthy volunteers. A total of 8 patients with lumbar disc prolapse and 8 healthy volunteers were recruited. An Agilent SurePrint G3 human gene expression microarray 8x60 K was used to perform the microarray analyses.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21185
16 Samples
Download data: TXT
Series
Accession:
GSE124272
ID:
200124272

Analyze with GEO2R

11.

Sleep Deprivation Alters the Pituitary Stress Transcriptome in male and female Mice

(Submitter supplied) We performed a comparative, whole-transcriptome, analysis to identify stress-induced genes and relevant pathways that may be affected by sleep deprivation. Methods: One day following 12 hours of Paradoxical Sleep Deprivation (PSD), mice were restrained for 20 minutes. Gene expression changes in the pituitary were assessed via RNA-Seq and Gene Ontology in PSD and/or restrained groups compared to controls. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
28 Samples
Download data: TXT
Series
Accession:
GSE133334
ID:
200133334

SRA Run Selector

12.

A Druggable TCF4- and BRD4-dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm (RNA-Seq)

(Submitter supplied) Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive and largely incurable hematologic malignancy originating from plasmacytoid dendritic cells (pDCs). Using RNA interference screening, we identified the E-box transcription factor TCF4 as a master regulator of the BPDCN oncogenic program. TCF4 served as a faithful diagnostic marker of BPDCN, and its downregulation caused the loss of the BPDCN-specific expression program and apoptosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL18573
14 Samples
Download data: XLS, XLSX
Series
Accession:
GSE84471
ID:
200084471

Analyze with GEO2RSRA Run Selector

13.

Neuronal changes induced by Varicella Zoster Virus in a rat model of Post Herpetic Neuralgia

(Submitter supplied) Neuronal reactivation of latent varicella zoster virus (VZV) causes debilitating and protracted pain (post herpetic neuralgia: PHN) in a significant fraction of patients. Productive infection of VZV seems to occur only in humans and primates, so VZV-infected human cells (e.g., MEWO cell line) are used to transmit VZV to rodents. A commonly accepted method of assessing nociception is ipsilateral nocifensive (pain avoidance) behavior in rats which have been injected in a footpad. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE64345
ID:
200064345

Analyze with GEO2R

14.

Large-Scale Expression Analysis Reveals Distinct microRNA Profiles at Different Stages of Human Neurodevelopment

(Submitter supplied) Background: MicroRNAs (miRNAs) are short non-coding RNAs predicted to regulate one third of protein-coding genes via mRNA targeting. In conjunction with key transcription factors, such as the repressor REST (RE1 silencing transcription factor), miRNAs play crucial roles in neurogenesis, which requires a highly orchestrated program of gene expression to ensure the appropriate development and function of diverse neural cell types. more...
Organism:
Homo sapiens; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL8415
51 Samples
Download data: TXT
Series
Accession:
GSE15888
ID:
200015888

Analyze with GEO2R

15.

HC

Organism:
Rattus norvegicus
Source name:
trigeminal neuralgia
Platform:
GPL25947
Series:
GSE233838
Download data
Sample
Accession:
GSM7437660
ID:
307437660

SRA Run Selector

16.

TN3

Organism:
Rattus norvegicus
Source name:
trigeminal neuralgia
Platform:
GPL25947
Series:
GSE233838
Download data
Sample
Accession:
GSM7437659
ID:
307437659

SRA Run Selector

17.

TN2

Organism:
Rattus norvegicus
Source name:
trigeminal neuralgia
Platform:
GPL25947
Series:
GSE233838
Download data
Sample
Accession:
GSM7437658
ID:
307437658

SRA Run Selector

18.

TN1

Organism:
Rattus norvegicus
Source name:
trigeminal neuralgia
Platform:
GPL25947
Series:
GSE233838
Download data
Sample
Accession:
GSM7437657
ID:
307437657

SRA Run Selector

19.

CITE-seq sample of CSF immune cells from individual with postherpetic neuralgia ADT

Organism:
Homo sapiens
Source name:
Cerebrospinal Fluid
Platform:
GPL18573
Series:
GSE244499
Download data
Sample
Accession:
GSM7818262
ID:
307818262

SRA Run Selector

20.

CITE-seq sample of CSF immune cells from individual with postherpetic neuralgia GEX

Organism:
Homo sapiens
Source name:
Cerebrospinal Fluid
Platform:
GPL18573
Series:
GSE244499
Download data
Sample
Accession:
GSM7818261
ID:
307818261

SRA Run Selector

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