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GEO DataSets

Functional Genomics Studies

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Items: 14

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Select item 2002737801.

Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome

(Submitter supplied) Background - Prepregnancy overweight and obesity promote deleterious health impacts on both mothers during pregnancy and the offspring. Significant changes in the maternal peripheral blood mononuclear cells (PBMCs) gene expression due to obesity are well-known. However, during pregnancy the impact of overweight on immune cell gene expression and its association with maternal and infant outcomes is not well explored. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
59 Samples

Download data: CSV

Series

Accession:: GSE273780

ID:: 200273780

Analyze with GEO2R

Select item 2002220542.

Targeted gene expression panel for meningiomas

(Submitter supplied) A custom Nanostring nCounter panel of 100 or 75 meningioma related genes and reference genes was developed, and performed on human frozen and FFPE meningioma samples. This was done as part of a study developing and validating a targeted gene expression biomarker for meningioma outcomes after surgey and benefit from raditherapy.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL32994
1202 Samples

Download data: RCC, XLSX

Series

Accession:: GSE222054

ID:: 200222054

PubMed Full text in PMC Similar studies

Select item 2001790393.

Epigenetic aging of the demographically non-aging naked mole-rat [RRBS]

(Submitter supplied) The naked mole-rat (NMR) is an exceptionally long-lived rodent that does not show increased mortality with age, uniquely defining NMR as a demographically non-aging mammal. Here, we performed bisulfite sequencing on over one hundred NMR blood samples differing in age, assessing more than 3 million common CpG sites. We observed an information loss of the NMR methylome during aging suggesting that NMR ages. more...

Organism:: Heterocephalus glaber

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL21195
107 Samples

Download data: COV

Series

Accession:: GSE179039

ID:: 200179039

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001490094.

Proteogenomic anlalysis of glioblastoma (GBM)

(Submitter supplied) To examine patterns associated with survival, we assembled a cohort of GBM patients whose survival ranges from less than 3 months and up to 10 years, most of which are not bearing isocitrate-dehyderogenase (IDH)-1 mutation and did not undergo prior treatment. We integrated high-resolution mass-spectrometry proteomics and RNA sequencing to examine the yet unresolved proteomic contribution to poor patient outcome, and compared it to the more established transcriptomic contribution and to published single-cell data. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
68 Samples

Download data: TXT

Series

Accession:: GSE149009

ID:: 200149009

PubMed Similar studies SRA Run Selector

Select item 2001024405.

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

(Submitter supplied) RhCMV-based TB vaccines are able to elicit and maintain immune effector responses that can control Mtb at the earliest stages of infection, and the protection afforded by this vaccine can be complete, if not sterilizing. To our knowledge, this is the first demonstration of complete prevention of TB disease in Rhesus Macaques (RM) by a long-acting vaccine after highly pathogenic (Erdman strain) Mtb challenge.

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platform:: GPL14954
168 Samples

Download data: CSV

Series

Accession:: GSE102440

ID:: 200102440

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000429556.

Expression data from human heart

(Submitter supplied) Global gene expression is altered in heart failure. This syndrome can be caused by cardiovascular diseases, including dilated cardiomyopathy (DCM), ischemic cardiomyopathy (ICM), hypertrophic cardiomyopathy, viral or toxic myocarditis, hypertension, and valvular diseases. We used microarrays to evaluate the impact of heart failure on human nucleocytoplasmic transport-related genes examining simultaneoulsly both dilated and ischemic human cardiomyopathies compared to normal hearts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4772
Platform:: GPL6244
29 Samples

Download data: CEL, CHP

Series

Accession:: GSE42955

ID:: 200042955

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 47727.

Dilated cardiomyopathy: left ventricle apex

Analysis of left ventricle (LV) from explanted hearts of male patients with dilated cardiomyopathy (DCM). DCM is characterized by systolic contractile dysfunction of the cardiac chambers. Results provide insight into molecular mechanisms underlying the changes in LV function observed in DCM.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state sets

Platform:: GPL6244
Series:: GSE42955
17 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4772

ID:: 4772

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000337568.

tRNAs marked with CCACCA are targeted for degradation

(Submitter supplied) The CCA-adding enzyme adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-adding enzyme plays a key role in tRNA quality control by selectively marking unstable tRNAs and tRNA-like small RNAs for degradation. Instead of adding CCA to the 3' ends of these transcripts, CCA-adding enzymes from all three kingdoms of life add CCACCA. more...