Xeraea argentina - GEO DataSets

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Select item 2002446201.

Skin transcriptome analysis in Brangus cattle under heat stress

(Submitter supplied) Heat stress is a major factor that negatively affects animal welfare and production systems. Livestock should adapt to tropical and subtropical areas and to meet this, composite breeds have been developed. This work aimed to evaluate gene expression profiles in the skin of Brangus cattle under heat stress using a case-control design, and to correlate this with skin histological characteristics. Two groups of bulls were set using rectal temperature as a criterion to define stress conditions: stressed (N=5) and non-stressed (N=5) groups. more...

Organism:: Bos taurus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26012
10 Samples

Download data: TXT

Series

Accession:: GSE244620

ID:: 200244620

Select item 2002421962.

RNA candidate screening in cell-to-cell contact-induced differentiation of human Pulmonary Artery Smooth Muscle Cells (hPASMC, Lonza)

(Submitter supplied) Smooth muscle cells retain a high plasticity in adulthood, allowing them to change between a differentiated, contractile phenotype and a dedifferentiated, proliferative and migrative phenotype in response to microenvironmental cues. This plasticity is key to maintain the structure and function of vessel walls. When disregulated, it can lead to the onset of vascular pathologies related to vascular remodeling and excessive extracellular matrix deposition. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

Download data: TXT

Series

Accession:: GSE242196

ID:: 200242196

PubMed Full text in PMC Similar studies

Select item 2002353553.

miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL19117 GPL18573
19 Samples

Download data: CEL

Series

Accession:: GSE235355

ID:: 200235355

Analyze with GEO2R

Select item 2002353544.

miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome [sequencing]

(Submitter supplied) Breast cancer (BCa) is the leading cause of death by cancer in women worldwide. Early diagnosis is improving the survival of BCa patients but more sensitive and specific tools are still necessary. We propose the use of miRNAs as a biomarker alternative in BCa diagnosis. MiRNAs are small non-coding RNAs that regulate gene expression. Circulating miRNAs can be detected in body fluids. Aberrant expression of miRNAs in both tissues and fluids are linked to several pathologies. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
10 Samples

Download data: CSV

Series

Accession:: GSE235354

ID:: 200235354

Select item 2002353535.

miRNA expression data in plasma from women with breast cancer and healthy volunteers with or without alterations associated to metabolic syndrome [array]

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL19117
9 Samples

Download data: CEL

Series

Accession:: GSE235353

ID:: 200235353

Analyze with GEO2R

Select item 2002535606.

Transcriptome and microbiome-immune changes across preinvasive and invasive anal cancer lesions

(Submitter supplied) Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy that is linked to high-risk Human papillomavirus (HPV) infection. It is often preceded by precursor lesions like Low-Grade Squamous Intraepithelial Lesions (LGSIL) and High-Grade Squamous Intraepithelial Lesions (HGSIL). The incidence of ASCC varies across populations, with heightened risk in HIV-positive individuals. In a previous study, we characterized the anal microbiome in high-risk HIV-exposed MSM and TGW subjects. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
70 Samples

Download data: TXT

Series

Accession:: GSE253560

ID:: 200253560

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002497967.

Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
14 Samples

Download data: MTX, TSV

Series

Accession:: GSE249796

ID:: 200249796

PubMed Full text in PMC Similar studies

Select item 2002497958.

Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus [ds1]

(Submitter supplied) To profile neurogenesis in the adult mouse hippocampus, we utilized a strategy to isolate developing cells derived from RGLs expressing the proneural gene Achaete-scute homolog 1 (Ascl1). Tamoxifen administration to young-adult Ascl1CreERT2;CAGfloxStopSun1sfGFP mice were used to induce the expression of Sun1-sfGFP in the nuclear membrane of RGLs and permanently label their progeny. This birthdating tag enabled a comprehensive analysis of the entire process encompassing neuronal differentiation, development, and functional maturation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: MTX, RDATA, TAB, TSV

Series

Accession:: GSE249795

ID:: 200249795

PubMed Full text in PMC Similar studies

Select item 2002497949.

Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus [ds2]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
10 Samples

Download data: MTX, RDATA, TAB, TSV

Series

Accession:: GSE249794

ID:: 200249794

PubMed Full text in PMC Similar studies

Select item 20026092510.

Unveiling the Role of KSHV-Infected Human Mesenchymal Stem Cells in Kaposi's Sarcoma Initiation

(Submitter supplied) Kaposi's sarcoma (KS) may derive from Kaposi's Sarcoma Herpesvirus (KSHV)-infected human Mesenchymal Stem Cells (hMSCs) that migrate to sites characterized by inflammation and angiogenesis, promoting the initiation of KS. By analyzing the RNA sequences of KSHV-infected primary hMSCs, we have identified specific cell subpopulations, mechanisms, and conditions involved in the initial stages of KSHV-induced transformation and reprogramming of hMSCs into KS progenitor cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
24 Samples

Download data: CSV

Series

Accession:: GSE260925

ID:: 200260925

Select item 20023601611.

GPR158 Activates Cellular Stress Responses in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways: Implications for Ocular Hypertension

(Submitter supplied) Background: the major risk factor for glaucoma is ocular hypertension, a disorder caused by reduced outflow of aqueous humor through the trabecular meshwork. In a previous pharmacogenomic screen for genes associated with ocular hypertension, we identified the novel G protein-coupled receptor, GPR158, and showed it protects against age-related ocular hypertension in mice. Here we show that the glucocorticoid, dexamethasone, increases the level of accumulated GPR158 protein in the trabecular meshwork of the human eye, ex vivo. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
36 Samples

Download data: DOCX, IDAT, TXT, XLSX

Series

Accession:: GSE236016

ID:: 200236016

Select item 20024250412.

Accelerated evolution in the human lineage led to gain and loss of transcriptional enhancers in the RBFOX1 locus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
20 Samples

Download data

Series

Accession:: GSE242504

ID:: 200242504

PubMed Full text in PMC Similar studies

Select item 20024250313.

Accelerated evolution in the human lineage led to gain and loss of transcriptional enhancers in the RBFOX1 locus [cortex]

(Submitter supplied) A long-standing goal of evolutionary biology is to decode how changes in gene regulatory networks contribute to human-specific traits. Human Accelerated Regions (HARs) are prime candidates for driving gene regulatory modifications in human development. The RBFOX1 locus is densely populated with HARs, providing a set of potential regulatory elements that could have changed its expression in the human lineage. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: CSV

Series

Accession:: GSE242503

ID:: 200242503

PubMed Full text in PMC Similar studies

Select item 20024250214.

Accelerated evolution in the human lineage led to gain and loss of transcriptional enhancers in the RBFOX1 locus [midbrain]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: CSV

Series

Accession:: GSE242502

ID:: 200242502

PubMed Full text in PMC Similar studies

Select item 20025425315.

Zika Virus Non-Coding RNAs Antagonize Antiviral Responses by PKR-Mediated Translational Arrest (Ribo-Seq)

(Submitter supplied) Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that causes severe outbreaks in human populations. ZIKV infection leads to the accumulation of small non-coding viral RNAs (known as sfRNAs) that are crucial for evasion of antiviral responses and for viral pathogenesis. However, the mechanistic understanding of how sfRNAs function remains incomplete. Here, we use recombinant ZIKVs and ribosome profiling of infected human cells to show that sfRNAs block translation of antiviral genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
6 Samples

Download data: TAB

Series

Accession:: GSE254253

ID:: 200254253

Select item 20025425216.

Zika Virus Non-Coding RNAs Antagonize Antiviral Responses by PKR-Mediated Translational Arrest (RNA-Seq)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
6 Samples

Download data: TAB

Series

Accession:: GSE254252

ID:: 200254252

Select item 20025425417.

Zika Virus Non-Coding RNAs Antagonize Antiviral Responses by PKR-Mediated Translational Arrest

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
12 Samples

Download data: TAB

Series

Accession:: GSE254254

ID:: 200254254

PubMed Similar studies

Select item 20024887218.

The miR390/TAS3/ARF module governs the expression of an LBD transcription factor to regulate nodulation and root architecture in Medicago truncatula

(Submitter supplied) The microRNA390 targets the TAS3 transcript leading to the production of trans-acting small interference RNAs that subsequently post-transcriptionally repress the mRNAs encoding the Auxin Response Factors (ARF)2, ARF3, and ARF4. This module has been linked to the development of lateral organs in both aerial and underground tissues. Previously, we have shown that the miR390/TAS3/ARFs module mediates the control of lateral roots and symbiotic nodules in legumes. more...

Organism:: Medicago truncatula

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33966
8 Samples

Download data: TXT

Series

Accession:: GSE248872

ID:: 200248872

Select item 20024630419.

A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli

(Submitter supplied) Circular RNAs are a large class of non-coding RNAs present in all eukaryotic taxa. Despite the identification of thousands of circular transcripts, the biological significance of most of them remains largely unexplored, partly due to the lack of effective methods for generating loss-of-function animal models. In this study, we focused on circTulp4, a highly abundant circRNA that is enriched in the brain and synaptic compartments. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
22 Samples

Download data: TXT

Series

Accession:: GSE246304

ID:: 200246304

PubMed Full text in PMC Similar studies

Select item 20023715720.

The transcription factor Oct6 promotes the dissolution of the naïve pluripotent state by repressing Nanog and activating a formative state gene regulatory network.

(Submitter supplied) Animal development is controlled by large gene regulatory networks (GRNs) that govern the nearly irreversible changes that occur when a cell differentiates into another cell type. In this work we aimed to determine key transcription factors (TFs) associated with the dissolution of the naïve pluripotent state and the acquisition of a formative identity. We identified Oct6 as one of the earliest TFs induced during the onset of mouse embryonic stem cell (mESCs) differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TXT

Series

Accession:: GSE237157

ID:: 200237157

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