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Items: 16

1.

Small Molecule Inducers of Neuroprotective miR-132 Identified by HTS-HTS in Human iPSC-derived Neurons

(Submitter supplied) MicroRNAs (miRNAs) are short RNAs that regulate fundamental biological processes. miR-132, a key miRNA with established functions in Tau homeostasis and neuroprotection, is consistently downregulated in Alzheimer’s disease (AD) and other tauopathies. miR-132 overexpression rescues neurodegenerative phenotypes in several AD models. To complement research on miRNA-mimicking oligonucleotides targeting the central nervous system, we developed a high-throughput-screen coupled high-throughput-sequencing (HTS-HTS) in human induced pluripotent stem cell (iPSC)-derived neurons to identify small molecule inducers of miR-132. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL21697
1441 Samples
Download data: XLSX
Series
Accession:
GSE216991
ID:
200216991

PubMed Full text in PMC Similar studies

2.

High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer

(Submitter supplied) We present TORNADO-seq —a high-throughput, a high-content drug discovery platform that for the first time uses next-generation sequencing (NGS) based, targeted RNA-seq in organoids monitoring the expression of 206 genes for the evaluation of complex mixtures of cellular phenotypes. TORNADO-seq is a fast, highly-reproducible, time- and cost-effective (5$ per sample including sequencing cost) method that we used to find drugs that enrich for differentiated cell phenotypes in intestinal organoids. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
1249 Samples
Download data: TXT
Series
Accession:
GSE157167
ID:
200157167

PubMed Similar studies SRA Run Selector

3.

Expression profiles in 3 different B-cell lymphoma cell lines treated by 92 FDA approved compounds

(Submitter supplied) Identifying the Mechanism of Action (MoA) of drugs is critical for the development of new drugs, understanding their side effects, and drug repositioning. However, identifying drug MoA has been challenging and has been traditionally attempted only though large experimental setups with little success. While advances in computational power offers the opportunity to achieve this in-silico, methods to exploit existing computational resources are still in their infancy. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
864 Samples
Download data: CEL
Series
Accession:
GSE60408
ID:
200060408

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

RSB163-84 [Sulfacetamide Sodium]

Organism:
Homo sapiens
Source name:
NGN2-iNs
Platform:
GPL21697
Series:
GSE216991
Download data
Sample
Accession:
GSM6702225
ID:
306702225

SRA Run Selector

5.

nxid8750: WT_Intestinal_organoids_Sulfacetamide_2_days_treatment_rep_2

Organism:
Mus musculus
Source name:
Intestinal organoids
Platform:
GPL19057
Series:
GSE157167
Download data
Sample
Accession:
GSM4758048
ID:
304758048

SRA Run Selector

6.

nxid10045: WT_Intestinal_organoids_Sulfacetamide_2_days_treatment_rep_3

Organism:
Mus musculus
Source name:
Intestinal organoids
Platform:
GPL19057
Series:
GSE157167
Download data
Sample
Accession:
GSM4758047
ID:
304758047

SRA Run Selector

7.

nxid6924: WT_Intestinal_organoids_Sulfacetamide_2_days_treatment_rep_1

Organism:
Mus musculus
Source name:
Intestinal organoids
Platform:
GPL19057
Series:
GSE157167
Download data
Sample
Accession:
GSM4758046
ID:
304758046

SRA Run Selector

8.

SULFACETAMIDE_U2932_24_TH001_NG_101118_08_C05

Organism:
Homo sapiens
Source name:
U2932
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1478844
ID:
301478844

9.

SULFACETAMIDE_U2932_12_TH001_NG_101118_07_C05

Organism:
Homo sapiens
Source name:
U2932
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1478748
ID:
301478748

10.

SULFACETAMIDE_U2932_6_TH001_NG_101118_06_C05

Organism:
Homo sapiens
Source name:
U2932
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1478652
ID:
301478652

11.

SULFACETAMIDE_OCI-Ly7_24_TH001_NG_101118_05_C05

Organism:
Homo sapiens
Source name:
OCI-Ly7
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1478556
ID:
301478556

12.

SULFACETAMIDE_OCI-Ly7_12_TH001_NG_101118_04_C05

Organism:
Homo sapiens
Source name:
OCI-Ly7
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1478460
ID:
301478460

13.

SULFACETAMIDE_OCI-Ly7_6_TH001_NG_101118_03_C05

Organism:
Homo sapiens
Source name:
OCI-Ly7
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1478364
ID:
301478364

14.

SULFACETAMIDE_OCI-Ly3_12_TH001_NG_110210_01_C05

Organism:
Homo sapiens
Source name:
OCI-Ly3
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1479132
ID:
301479132

15.

SULFACETAMIDE_OCI-Ly3_24_TH001_NG_101128_02_C05

Organism:
Homo sapiens
Source name:
OCI-Ly3
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1479036
ID:
301479036

16.

SULFACETAMIDE_OCI-Ly3_6_TH001_NG_101020_02_C05

Organism:
Homo sapiens
Source name:
OCI-Ly3
Platform:
GPL13667
Series:
GSE60408
Download data: CEL
Sample
Accession:
GSM1478940
ID:
301478940

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