POF1 - GEO DataSets

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Items: 13

Select item 2000560431.

Homozygosity mapping in family segregating premature ovarian insufficiency (POI)

(Submitter supplied) Premature ovarian insufficiency (POI) is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles before the age of 40 (secondary amenorrhea) with hypergonadotropism and hypoestrogenism. Premature ovarian insufficiency has few known genetic causes but in familial cases a genetic link is often suspected. A large consanguineous family with three female affected with POI was investigated. more...

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL18441
8 Samples

Download data: CEL, TXT

Series

Accession:: GSE56043

ID:: 200056043

Select item 2000489022.

Blood expression profiles of fragile X premutation carriers identify genes involved in neurodegenerative and infertility phenotypes [SHSY5Y]

(Submitter supplied) Fragile X premutation carriers (fXPC) of the CGG expansion in the 5’-UTR of the fragile X mental retardation 1 (FMR1) gene are at high risk of Fragile X Tremor/Ataxia Syndrome (FXTAS), and females might undergo Premature Ovarian Failure (POF1). We have evaluated the peripheral blood gene expression profiles of fXPC and detected a strong deregulation of genes enriched in FXTAS-relevant biological pathways, including inflammation, and neuronal homeostasis and survival. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16699
24 Samples

Download data: TXT

Series

Accession:: GSE48902

ID:: 200048902

Analyze with GEO2R

Select item 2000488733.

Blood expression profiles of fragile X premutation carriers identify genes involved in neurodegenerative and infertility phenotypes [FXTAS]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13607
15 Samples

Download data: TXT

Series

Accession:: GSE48873

ID:: 200048873

Select item 2000545844.

Altered Gene Expression Profile in Ovarian Follicle in Rats Treated with Indomethacin and RU486

(Submitter supplied) It is well-known that indomethacin (the cyclooxygenase 1 & 2 inhibitor) and RU486 (or mifepristone, the progesterone receptor antagonist) block follicular rupture in rats. To characterize genetic alterations in unruptured follicles, gene expression profiles in ovarian follicle were analyzed in indomethacin- and RU486-treated female Sprague-Dawley rats. Ovaries are collected at 22:00 on the proestrus day and 10:00 on the following estrus day after a single dose of indomethacin and RU486. more...