ursolic acid - GEO DataSets

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Select item 2001844851.

Phytogenics from sage and lemon verbena promote growth, systemic immunity and disease resistance in Atlantic salmon (Salmo salar)

(Submitter supplied) Deciphering the dietary immunomodulatory effects of a feed additive rich in verbascoside and triterpenic compounds like ursolic (MPLE, NATAC Biotech SL, Spain) on the systemic immune response and disease resistance of Atlantic salmon (Salmo salar L.) smolts.

Organism:: Salmo salar

Type:: Expression profiling by array

Platform:: GPL28080
6 Samples

Download data: TXT

Series

Accession:: GSE184485

ID:: 200184485

Analyze with GEO2R

Select item 2002769102.

Ursolic acid-induced DECR1 degradation via NF-κB/NLRP3 pathway inihibits vascular calcification

(Submitter supplied) In this study, we repoort the protective effect of ursolic acid (UA) on vascular calcification in chronic kidney disease. To elucidate the molecular mechanism underlying the anti-vascular calcification effect of UA, we performed RNA-seq to identify the gene expresion under UA treatmment.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
6 Samples

Download data: XLS

Series

Accession:: GSE276910

ID:: 200276910

Select item 2002728313.

Adipogenesis, lipolysis, and extracellular matrix remodeling are early modulated by a triterpene-enriched natural extract in a mouse cell line and primary human adipocytes

(Submitter supplied) Chronic Inflammation has a key role in the development of insulin resistance and type 2 diabetes. Previously, we demonstrated that OBE100, a natural extract from the leaves of Eucalyptus tereticornis, has anti-inflammatory properties. Three pentacyclic triterpenoids, ursolic acid, oleanolic acid, and ursolic acid lactone are the major compounds present in OBE100. These molecules have shown multiple biological activities. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20301 GPL21103
40 Samples

Download data: TXT

Series

Accession:: GSE272831

ID:: 200272831

Select item 2002640024.

Transcriptome profiling of ovaries in aged mice administered with individual ingredients of Samul-tang

(Submitter supplied) Samul-tang (SM) is a traditional multi-ingredient treatment widely used in clinical practice for improving ovarian function in women with diminished ovarian reserve. Despite its therapeutic benefits, the complexity of its mechanisms of action due to the combination of multiple compounds has limited its research integration into modern pharmacological science. To address this challenge, we identified 39 herbal compounds as major ingredients in SM and generated transcriptome data from the mice ovaries after administrating with individual ingredients. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
127 Samples

Download data: RESULTS

Series

Accession:: GSE264002

ID:: 200264002

Select item 2002516625.

Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins

(Submitter supplied) This investigation scrutinizes the implications and mechanistic underpinnings of ursolic acid's effect on busulfan-induced oligospermia in mouse models. A single intraperitoneal injection at a dose of 30mg/kg of busulfan induced oligospermia, and two weeks later, the mice were treated with varied dosages of ursolic acid (10, 30, and 50 mg/kg w.t., respectively) daily for four consecutive weeks. Following this, a meticulous analysis of epididymal sperm parameters encompassing concentration and motility were undertaken using a computer-assisted sperm analysis system. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28330
4 Samples

Download data: TXT

Series

Accession:: GSE251662

ID:: 200251662

PubMed Full text in PMC Similar studies

Select item 2002504716.

RNA-seq analysis reveals modulation of inflammatory pathways by an enriched-triterpene natural extract in mouse and human macrophage cell lines

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20301 GPL21103
41 Samples

Download data: TXT

Series

Accession:: GSE250471

ID:: 200250471

PubMed Full text in PMC Similar studies

Select item 2002144257.

Intergenerational Neuroprotection by an Intestinal Sphingolipid in Caenorhabditis elegans

(Submitter supplied) In animals, maternal diet and environment can influence the health of offspring. Whether and how maternal dietary choice impacts the nervous system across multiple generations is not well understood. Here, we show that feeding Caenorhabditis elegans with ursolic acid (UA), a natural plant product, reduces adult-onset neurodegeneration intergenerationally. UA provides neuroprotection by enhancing maternal provisioning of sphingosine-1-phosphate (S1P) - a bioactive sphingolipid. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19757
15 Samples

Download data: TSV

Series

Accession:: GSE214425

ID:: 200214425

Select item 2002300398.

Natural compounds ursolic acid and digoxin exhibit inhibitory activities to cancer cells in RORγ-dependent and -independent manner

(Submitter supplied) Natural compounds ursolic acid (UA) and digoxin isolated from fruits and other plants display potent anti-cancer effects in preclinical studies. UA and digoxin have been at clinical trials for treatment of different cancers including prostate cancer, pancreatic cancer and breast cancer. However, they displayed limited benefit to patients. Currently, a poor understanding of their direct targets and mechanisms of action (MOA) severely hinders their further development. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
14 Samples

Download data: XLSX

Series

Accession:: GSE230039

ID:: 200230039

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001665589.

Phytogenics from sage and lemon verbena promote innate immunity and barrier function in the gut of gilthead seabream (Sparus aurata)

(Submitter supplied) Deciphering the dietary immunomodulatory effects of a medicinal plant leaf extract (MPLE) obateined from sage (Salvia officinalis, Lamiaceae) and lemon verbena (Lippia citriodora, Verbenaceae) upon the gut-associated lymphoid tissue (GALT) of gilthead seabream (Sparus aurata).

Organism:: Sparus aurata

Type:: Expression profiling by array

Platform:: GPL13442
6 Samples

Download data: TXT

Series

Accession:: GSE166558

ID:: 200166558

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013639510.

The effects of a novel oral nutritional supplement as compared to standard care on body composition, physical function and skeletal muscle mRNA expression in Dutch older adults with (or at risk of) undernutrition

(Submitter supplied) In a randomized controlled trial, 82 older adults (>65y) with (or at risk of) undernutrition (n=82) were randomly allocated to 12 weeks of supplementation with a novel supplement (586 kcal, 22 g protein of which 50% whey and 50% casein, 206 mg ursolic acid, 7 g free BCAAs, 11 µg vitamin D) or standard care (600 kcal, 24g protein of which 100% casein, 4 µg vitamin D). Body weight increased significantly in the 12 weeks, both in the intervention group (+1.6 ± 0.2 kg, p<.0001) and in the standard care group (+1.8 ± 0.2 kg, p<.0001). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17692
42 Samples

Download data: CEL

Series

Accession:: GSE136395

ID:: 200136395

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015068811.

Ursolic acid regulates inflammatory cell infiltration to prevent ulcerative colitis

(Submitter supplied) Total RNA was isolated from 3 colonic tissues of each treatment group using the Qiagen RNeasy kit following the manufacturers' protocol. RNA samples with good quality control (RIN values>8) were sequenced using Hiseq-2500 by Novogene. Ursolic acid (UA), Dextran sulfate sodium (DSS)."Con" group stands for normal group, "DSS" group stands for DSS induced group, "UA_DSS" group stands for UA Preventive DSS induced group, "DSS_UA" group stands for UA Treatment DSS induced group.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE150688

ID:: 200150688

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012024312.

Ursolic acid attenuates hepatic steatosis, fibrosis, and insulin resistance by modulating the circadian rhythm pathway in diet-induced obese mice

(Submitter supplied) Background/Objectives: The aim of the current study was to elucidate the effects of long-term supplementation with dietary ursolic acid (UR) on obesity and associated comorbidities, such as hepatic fibrosis, by analyzing transcriptional and metabolic responses, focusing on the role of UR in the modulation of the circadian rhythm pathway in particular. Subjects/Methods: C57BL/6J mice were divided into three groups and fed a normal diet, high-fat diet (HFD), or high-fat + 0.05% (w/w) UR diet for 16 weeks. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
27 Samples

Download data: TXT

Series

Accession:: GSE120243

ID:: 200120243

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007265113.

Effects of ursolic acid and tomatidine on skeletal muscle mRNA expression in aged mice.

(Submitter supplied) For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy.