hydrochaeris nahuelbutae - GEO DataSets

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Select item 2002813861.

Bulk RNA sequencing of primary mouse microglia

(Submitter supplied) We used primary mouse microglia to determine whether Bruton's tyrosine kinase (BTK) inhibition could attenuate differential gene expression induced by Fc receptor stimulation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: CSV

Series

Accession:: GSE281386

ID:: 200281386

Select item 2002813492.

RNA sensing induced by chromosome missegregation augments anti-tumor immunity III

(Submitter supplied) We demonstrate that dsRNA is significantly accumulated in cancer cells following pharmacologic induction of micronuclei, stimulating MAVS-mediated dsRNA sensing in conjunction with the cGAS/STING pathway. Activation of cytosolic dsRNA sensing co-operates with dsDNA sensing to up-regulate immune cell migration and antigen-presenting machinery. Tracing of dsRNA-sequence identity revealed that dsRNA-forming transcripts are predominantly generated from non-exonic regions, particularly in locations proximal to genes exhibiting high chromatin accessibility. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE281349

ID:: 200281349

Select item 2002813023.

ESR1 Y537S and D538G mutations drive resistance to CDK4/6 inhibitors in estrogen receptor-positive breast cancer

(Submitter supplied) Purpose: Breast cancers with ESR1 mutations are resistant to antiestrogen therapy. We aimed to investigate the association of ESR1 mutations with resistance to CDK4/6 inhibitors (CDK4/6i) using real-world data analysis and experimental validation. Patients and Methods: A total of 3,958 patients with estrogen receptor-positive (ER+) metastatic breast cancer with DNA sequencing data were analyzed. Breast tumor DNA and circulating tumor (ct) DNA were sequenced using the Tempus xT tumor assay and Tempus xF liquid biopsy, respectively. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
36 Samples

Download data: TSV

Series

Accession:: GSE281302

ID:: 200281302

Select item 2002811354.

The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells

(Submitter supplied) Severe COVID-19 is characterized by a cytokine-mediated acute respiratory distress syndrome resembling toxic shock syndrome. We identified a SARS-CoV-2 S1 spike peptide (P3) with sequence homology to bacterial super-antigens. Computational modelling revealed P3 binding to MHC class I/II and TCR regions that partially overlap with staphylococcal enterotoxin B (SEB) and enterotoxin H (SEH) binding sites. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: CSV

Series

Accession:: GSE281135

ID:: 200281135

Select item 2002811145.

Protective mechanisms of Qingda granule in hypertensive kidney injury: Focus on ERK/RSK1-mediated mitochondrial protection

(Submitter supplied) The objective of this study was to compare blank control mice (WT) with AngII-induced hypertensive mice (M). Angii-induced hypertensive mice (M) and QDG intervention group (QDG); Different genes expressed in renal tissue and identify new targets for reversing hypertension-induced renal damage.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24688
9 Samples

Download data: TXT, XLSX

Series

Accession:: GSE281114

ID:: 200281114

Select item 2002807616.

Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections

(Submitter supplied) Glioblastoma is a major unmet clinical need characterized by striking inter- and intra-tumoral heterogeneity and a population of glioblastoma stem cells (GSCs), conferring aggressiveness and therapy resistance. GSCs communicate through a network of tumor-tumor connections (TTCs), including nanotubes and microtubes, promoting tumor progression. However, very little is known about the mechanisms underlying TTC formation and overall GSC morphology. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
10 Samples

Download data: CSV, TSV

Series

Accession:: GSE280761

ID:: 200280761

Select item 2002781997.

Microglia regulate cortical remyelination via ΤNFR1-dependent phenotypic polarization [scRNA-Seq]

(Submitter supplied) Microglia are strongly implicated in demyelinating neurodegenerative diseases with increasing evidence for roles in protection and healing, but the mechanisms that control CNS remyelination are poorly understood. Here we show that microglia-specific deletion of TNFR1 and pharmacological inhibition of soluble TNF (solTNF) or downstream IL-1R allow maturation of highly activated disease-associated microglia with increased size and myelin phagocytosis capacity that accelerate cortical remyelination and motor recovery. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
45 Samples

Download data: RDS

Series

Accession:: GSE278199

ID:: 200278199

Select item 2002781378.

Microglia regulate cortical remyelination via ΤNFR1-dependent phenotypic polarization [RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
28 Samples

Download data: RESULTS

Series

Accession:: GSE278137

ID:: 200278137

Select item 2002765489.

DNA methylome sequencing of aged vs young AT2 cells

(Submitter supplied) EM-Seq of DNA derived from freshly sorted AT2 cells from aged (24-30 months old) and young (3-4 months old) C57BL6/J mice

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24247
44 Samples

Download data: BW, RDS

Series

Accession:: GSE276548

ID:: 200276548

Select item 20026703910.

PRDX1-TLR4-p65 axis inhibits RANKL-mediated osteoclast differentiation

(Submitter supplied) Peroxiredoxin 1 (PRDX1), traditionally known as an intracellular antioxidant enzyme, has emerged as a regulator of inflammatory responses via Toll-like receptor 4 (TLR4) signaling. Despite this, the mechanistic details of the PRDX1-TLR4 axis and its impact on osteoclast differentiation remain elusive. Here, we show that PRDX1 suppresses RANKL-induced osteoclast differentiation. Utilizing pharmacological inhibitors, we reveal that PRDX1 inhibits osteoclastogenesis through both TLR4/TRIF and TLR4/MyD88 pathways. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: TXT

Series

Accession:: GSE267039

ID:: 200267039

Select item 20026419911.

Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis

(Submitter supplied) Ex vivo expansion of hematopoietic stem cells (HSC) requires the maintenance of a stemness state while cells are proliferating. This can be achieved via exposure to UM171 which leads to the degradation of chromatin modifiers and prevents the loss of key epigenetic marks. However, the chromatin landscape varies across populations within the hematopoietic system and the effect of UM171 on self-renewal and differentiation potential of different hematopoietic progenitor cells is less characterized. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
5 Samples

Download data: CSV

Series

Accession:: GSE264199

ID:: 200264199

Select item 20026255812.

Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts [skin scRNA-seq]

(Submitter supplied) Interaction of mast cells (MCs) with fibroblasts is essential for MC maturation within tissue microenvironments, although the underlying mechanism is incompletely understood. Through a phenotypic screening of >30 mouse lines deficient in lipid-related genes, we found that deletion of the lysophosphatidic acid (LPA) receptor LPA1, like that of the phospholipase PLA2G3, the prostaglandin D2 (PGD2) synthase L-PGDS, or the PGD2 receptor DP1, impairs MC maturation and thereby anaphylaxis. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL24247
4 Samples

Download data: TXT, XLSX

Series

Accession:: GSE262558

ID:: 200262558

Select item 20025451113.

DICER is downregulated in mouse adipose tissue during high-fat diet feeding

(Submitter supplied) The adipose tissue plays an important role in controlling whole-body energy balance, and proper regulation of adipose tissue function is essential for metabolic health. In response to energy surplus, the adipose tissue needs to expand, which may lead to local areas of hypoxia within the tissue. This is thought to promote whole-body insulin resistance. Here we report that DICER, a key enzyme in the maturation of miRNAs and a potential marker of adipocyte health, is profoundly downregulated in mouse adipose tissue within the first week of high-fat diet (HFD) feeding, and this effect is sustained in response to long-term HFD feeding. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: CSV

Series

Accession:: GSE254511

ID:: 200254511

Select item 20025352914.

Effects of choline deficiency in mouse photoreceptor cell line 661W

(Submitter supplied) Although mutations in human patatin-like phospholipase PNPLA6 are associated with hereditary retinal degenerative diseases, its mechanistic action in the retina is poorly understood. Here, we uncover the molecular mechanism by which PNPLA6 dysfunction disturbs retinal homeostasis and visual function. PNPLA6, by acting as a phospholipase B, regulates choline mobilization from phosphatidylcholine and subsequent choline turnover for phosphatidylcholine regeneration in retinal pigment epithelial (RPE) cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10333
2 Samples

Download data: TXT

Series

Accession:: GSE253529

ID:: 200253529

Select item 20025352615.

Effects of knockdown or overexpression of PNPLA6 in human retinal pigment epithelial cell line ARPE-19

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10332
4 Samples

Download data: TXT

Series

Accession:: GSE253526

ID:: 200253526

Select item 20025336116.

Lipid-orchestrated paracrine circuit coordinates mast cell maturation through functional interaction with fibroblasts [fibroblast]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10333
4 Samples

Download data: TXT

Series

Accession:: GSE253361

ID:: 200253361

Select item 20025335617.

Lipid-orchestrated paracrine circuit coordinates mast cell maturation through functional interaction with fibroblasts [mast cell]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10333
6 Samples

Download data: TXT

Series

Accession:: GSE253356

ID:: 200253356

Select item 20024967418.

Intratumoral administration of lipid nanoparticles carrying mRNA encoding for IL-21, IL-7, and 4-1BBL induces anti-tumor immunity in preclinical tumor models.

(Submitter supplied) Local delivery of mRNA-based immunotherapy offers a promising avenue for personalized medicine as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells, showcasing encouraging results in preclinical tumor models while minimizing systemic side effects. Nonetheless, efficient mRNA delivery is challenging due to its rapid degradation by ribonucleases and limited cellular uptake. more...