GEO DataSets

(Submitter supplied) The functions of key oncogenic transcription factors independent of context have not been fully delineated despite our richer understanding of the genetic alterations in human cancers. The MYC oncogene, which produces the Myc transcription factor, is frequently altered in human cancer and is a major regulatory hub for many cancers. In this regard, we sought to unravel the primordial signature of Myc function by using high-throughput genomic approaches to identify the cell-type independent core Myc target gene signature. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL4133 GPL5175 GPL5082

15 Samples

Download data: BAR, CEL, TXT

(Submitter supplied) Myc plays important roles in cancer and stem cell biology including reprogramming adult cells to pluripotent stem cells. We have indentified a core set of Myc target genes in human B-cells and embryonic stem cells by genome wide ChIP-on-chip and transcriptional profiling.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5082

3 Samples

Download data: BAR, BED, CEL

(Submitter supplied) The GeneChip® Human Promoter 1.0R Array is designed for chromatin immunoprecipitation (ChIP) experiments. The Human Promoter Array is a single array comprised of over 4.6 million probes tiled through over 25,500 human promoter regions. Sequences used in the design of the Human Promoter array were selected from NCBI human genome assembly (Build 34). Repetitive elements were removed by RepeatMasker. Promoter regions were selected using sequence information from: 35,685 ENSEMBL genes (version 21_34d, May 14, 2004) 25,172 RefSeq mRNAs (NCBI GenBank®, February 7, 2004) 47,062 complete-CDS mRNA (NCBI GenBank, December 15, 2003) Probes are tiled at an average resolution of 35 bp, as measured from the central position of adjacent 25-mer oligos, leaving a gap of approximately 10 bp between probes. more...

Organism:

Homo sapiens

88 Series

1078 Samples

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