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Items: 4

1.

PRC2.1 and PRC2.2 synergize to co-ordinate H3K27 tri-methylation. 

(Submitter supplied) Polycomb Repressive Complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di- and tri-methylation of Histone H3 at Lysine 27. While at least two subcomplexes exist, defined by their specific accessory proteins, termed PRC2.1 (Polycomb-like proteins 1-3, EPOP and PALI1/2) and PRC2.2 (AEBP2 and JARID2), little is known about their differential functions. Here, we show that PRC2.1 and PRC2.2 share the majority of target genes in mouse embryonic stem cells (ESCs). The loss of all three Polycomb-like proteins is sufficient to destabilise and evict PRC2.1 from chromatin, but also leads to reduced PRC2.2 and H3K27me3 at most Polycomb domains. However, the combined loss of PRC2.1 and PRC2.2 is necessary to completely remove H3K27me3 at broad Polycomb domains such as the Hox loci. Our data support a model in which the specific accessory proteins within PRC2.1 and PRC2.2 co-operate to direct and maintain H3K27me3, via both synergistic and independent mechanisms.
Organism:
Drosophila melanogaster; Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19415 GPL25537
37 Samples
Download data: BW
Series
Accession:
GSE133412
ID:
200133412
2.

Variant PRC2.1 and PRC2.2 co-operate to direct H3K27 methylations in ESCs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Drosophila melanogaster; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19415 GPL19057 GPL25537
79 Samples
Download data: BW
Series
Accession:
GSE127121
ID:
200127121
3.

Illumina NextSeq 500 (Homo sapiens; Mus musculus)

Organism:
Homo sapiens; Mus musculus
93 Series
1635 Samples
Download data
Platform
Accession:
GPL19415
ID:
100019415
4.

mm10_J2_KO_Pcl2

Organism:
Mus musculus; Homo sapiens
Source name:
Embryonic stem cell and NT2 cell line
Platform:
GPL19415
Series:
GSE127121 GSE133412
Download data: BW
Sample
Accession:
GSM3908361
ID:
303908361
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