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Items: 4

1.

Selective Inhibition of the Second Bromodomain of BET Family Maintains Anti-Tumor Efficacy and Improves Tolerability (22RV1 RNA-seq)

(Submitter supplied) Here we report the discovery of ABBV-744, a first in class, highly potent and selective inhibitor of BET family BD2 domains with drug like properties. RNA-seq analysis revealed that ABBV-744 elicited potent inhibition of AR-dependent transcription without causing broad transcription alterations associated with exposure to pan BET inhibitors.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
10 Samples
Download data: TXT
Series
Accession:
GSE130247
ID:
200130247
2.

Selective Inhibition of the Second Bromodomain of BET Family Maintains Anti-Tumor Efficacy and Improves Tolerability

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
20 Samples
Download data
Series
Accession:
GSE130269
ID:
200130269
3.

Illumina HiSeq 3000 (Homo sapiens)

Platform
Accession:
GPL21290
ID:
100021290
4.

c114416_rnaseq_uziel_22rv1_18: 22RV1_DHT ENZ rep2

Organism:
Homo sapiens
Source name:
22RV1 immortalized prostate cancer cell line
Platform:
GPL21290
Series:
GSE130247 GSE130269
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Sample
Accession:
GSM3734481
ID:
303734481
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Supplemental Content

db=gds|term=GSM3734481[Accession]|query=9|qty=2|blobid=MCID_672e9702ad0a37579f51c066|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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