|
| Status |
Public on Oct 23, 2019 |
| Title |
Selective Inhibition of the Second Bromodomain of BET Family Maintains Anti-Tumor Efficacy and Improves Tolerability (22RV1 RNA-seq) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Here we report the discovery of ABBV-744, a first in class, highly potent and selective inhibitor of BET family BD2 domains with drug like properties. RNA-seq analysis revealed that ABBV-744 elicited potent inhibition of AR-dependent transcription without causing broad transcription alterations associated with exposure to pan BET inhibitors.
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| |
|
| Overall design |
mRNA profiles of 22RV1 cells treated with ABBV-075, ABBV-744, or Enzalutmide in the presence or absence of DHT were generated by deep sequencing, in duplicate, using Illumina HiSeq3000.
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| |
|
| Contributor(s) |
Faivre E, Lu X |
| Citation(s) |
31969702 |
| Submission date |
Apr 24, 2019 |
| Last update date |
Jan 24, 2020 |
| Contact name |
Xin Lu |
| E-mail(s) |
xin.x.lu@abbvie.com
|
| Phone |
847-937-7942
|
| Organization name |
Abbvie
|
| Department |
Oncology Discovery
|
| Street address |
1 North Waukegan Rd
|
| City |
North Chicago |
| State/province |
IL |
| ZIP/Postal code |
60064 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (10)
|
| GSM3734476 |
c114416_rnaseq_uziel_22rv1_13: 22RV1_EtOH_DMSO rep1 |
| GSM3734477 |
c114416_rnaseq_uziel_22rv1_14: 22RV1_EtOH_DMSO rep2 |
| GSM3734478 |
c114416_rnaseq_uziel_22rv1_15: 22RV1_DHT_DMSO rep1 |
| GSM3734479 |
c114416_rnaseq_uziel_22rv1_16: 22RV1_DHT_DMSO rep2 |
| GSM3734480 |
c114416_rnaseq_uziel_22rv1_17: 22RV1_DHT_ENZ rep1 |
| GSM3734481 |
c114416_rnaseq_uziel_22rv1_18: 22RV1_DHT ENZ rep2 |
| GSM3734482 |
c114416_rnaseq_uziel_22rv1_19: 22RV1_DHT_ABBV-075 rep1 |
| GSM3734483 |
c114416_rnaseq_uziel_22rv1_20: 22RV1_DHT_ABBV-075 rep2 |
| GSM3734484 |
c114416_rnaseq_uziel_22rv1_21: 22RV1_DHT_ABBV-744 rep1 |
| GSM3734485 |
c114416_rnaseq_uziel_22rv1_22: 22RV1_DHT_ABBV-744 rep2 |
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| This SubSeries is part of SuperSeries: |
| GSE130269 |
Selective Inhibition of the Second Bromodomain of BET Family Maintains Anti-Tumor Efficacy and Improves Tolerability |
|
| Relations |
| BioProject |
PRJNA534446 |
| SRA |
SRP193708 |
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